Pulsatile Delivery of Drug for a Range of Diseases

Nikam, Sanket; Jadhav, Prakash; Chaudhari, Bharti; Velhal, Atish B.

doi:10.52711/2231-5659.2022.00056

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronological behavior Drugs investigated Asthma [30] Asthma is an ongoing inflammatory condition of the lungs. Chronic inflammation is linked to airway hyperresponsiveness (an exaggerated airway-narrowing response to specific triggers such as viruses, allergens, and exercise), which results in recurrent episodes of wheezing, breathlessness, chest tightness, and/or coughing that can vary in intensity over time and over time.…”

Section: Diseasementioning

confidence: 99%

“…Chronic inflammation is linked to airway hyperresponsiveness (an exaggerated airway-narrowing response to specific triggers such as viruses, allergens, and exercise), which results in recurrent episodes of wheezing, breathlessness, chest tightness, and/or coughing that can vary in intensity over time and over time. Symptom episodes are commonly linked with widespread but varying airflow blockage inside the lungs, which is usually reversible either on its own or with proper asthma medication, such as a fast-acting bronchodilator [30].…”

Section: Diseasementioning

confidence: 99%

See 1 more Smart Citation

Pulsatile Drug Delivery Systems the Novel Approach

BODKE,

TEKADE,

BADEKAR

et al. 2024

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.

show abstract

Section: Diseasementioning

confidence: 99%

Section: Diseasementioning

confidence: 99%

Pulsatile Drug Delivery Systems the Novel Approach

BODKE,

TEKADE,

BADEKAR

et al. 2024

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

Synthetic Biology of Plants-Derived Medicinal Natural Products

Nipunta,

Kaur,

Sagar

et al. 2024

Biosynthesis of Natural Products in Plants

View full text Add to dashboard Cite

Comparative Characterization of Marketed Antacid Granules

D. Dandgawal,

Y. Pagar,

M. Patil

2023

AJPS

View full text Add to dashboard Cite

Before inhibitors of the proton pump and antagonists of the H2 receptor, the mainstay of therapy was antacids for acid-peptic diseases. In this work different tests for characterization of different brands of antacid granules were carried out. This study set out to compare the quality of five antacid brands. Angle of repose, Bulk density, Tapped density, Carr's index, Hausner's ratio, Effervescent duration, Preliminary Antacid Test, Acid Neutralizing Capacity, Reheis Test, and Rosette Rice Test were used to compare the antacid granules. In the examination of several antacid granules available in the market, the values of bulk density, tapped density, angle of repose, carr's index, and hausner's ratio reveal that Brands A, B, and D have good flow property, Brand C has fair property, and Brand E has passable flow property. Brand A has a shorter effervescent time than other brands, while Brand D has a longer one. Because the antacid-acid (HCl) solution's pH for each brand is found to be greater than pH 3.5, all of the brands are considered to be antacids. The acid neutralizing capacity (ANC) test reveals that none of the antacid products meet the US FDA's requirement that they have an acid neutralizing capacity of at least 5 mEq. The Reheis test revealed that Brand B needed more time than other brands to neutralize, but Brand D needed less time. Brand A required less time than other brands to maintain the pH level between 3 and 5, while Brand D required more time, according to the Rosette rice test.

show abstract

Pulsatile Delivery of Drug for a Range of Diseases

Cited by 3 publications

References 17 publications

Pulsatile Drug Delivery Systems the Novel Approach

Pulsatile Drug Delivery Systems the Novel Approach

Synthetic Biology of Plants-Derived Medicinal Natural Products

Comparative Characterization of Marketed Antacid Granules

Contact Info

Product

Resources

About