Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres

Kaassis, Abdessamad Y. A.; Young, Neil P.; Sano, Naoko; Merchant, Hamid A.; Yu, Deng‐Guang; Chatterton, Nicholas P.; Williams, Gareth R.

doi:10.1039/c3tb21605e

Cited by 33 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, fifth-generation SDs can provide a biphasic drug release profile (with both fast and sustained release phases) where a number of performance factors can be controlled in a highly tuneable manner. These factors include the amount of drug release occurring in the first and second phases [204], the drug release target sites [205], the release mechanism [206], and the release rates in the sustained release phase [207]. It is easy to conceive of a system where two poorly water-soluble APIs…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In terms of polymer selection, almost all polymers used in pharmaceutics or as edible coatings for food products can be used for electrospinning, provided that the drug and the polymer share a solvent or solvent mixture. Some of these polymers include PVP [224], PEO [227], PVA [11], HPMC [64], the Eudragit series [228] and also natural polymers such as gelatin [206]. In addition, other water soluble pharmaceutical excipients such as β-cyclodextrin and its derivatives can also be used to prepare second-generation ASDs [229].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

Self Cite

250

156

View full text Add to dashboard Cite

The development of oral dosage forms for poorly water-soluble active pharmaceutical ingredients (APIs) is a persistent challenge. A range of methods has been explored to address this issue, and amorphous solid dispersions (ASDs) have received increasing attention. ASDs are typically prepared by starting with a liquid precursor (a solution or melt) and applying energy for solidification. Many techniques can be used, with the emergence of electrospinning as a potent option in recent years. This method uses electrical energy to induce changes from liquid to solid. Through the direct applications of electrical energy, electrospinning can generate nanofiber-based ASDs from drug-loaded solutions, melts and melt-solutions. The technique can also be combined with other approaches using the application of mechanical, thermal or other energy sources. Electrospinning has numerous advantages over other approaches to produce ASDs. These advantages include extremely rapid drying speeds, ease of implentation, compatibility with a wide range of active ingredients (including those which are thermally labile), and the generation of products with large surface areas and high porosity. Furthermore, this technique exhibits the potential to create so-called 'fifth-generation' ASDs with nanostructured architectures, such as core/shell or Janus systems and their combinations. These advanced systems can improve dissolution behaviour and provide programmable drug release profiles. Additionally, the fiber components and their spatial distributions can be precisely controlled. Electrospun fiber-based ASDs can maintain an incorporated active ingredient in the amorphous physical form for prolonged periods of time because of their homogeneous drug distribution within the polymer matrix (typically they comprise solid solutions), and ability to inhibit molecular motion. These ASDs can be utilised to generate oral dosage forms for poorly water-soluble drugs, resulting in linear or multiple-phase release of one or more APIs. Electrospun ASDs can also be exploited as templates for manipulating molecular self-assembly, offering a bridge between ASDs and other types of dosage forms. This review addresses the development, advantages and pharmaceutical applications of electrospinning for producing polymeric ASDs. Material preparation and analysis procedures are considered. The mechanisms through which performance has been improved are also discussed.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

Self Cite

250

156

View full text Add to dashboard Cite

show abstract

“…mechanical properties and microstructures) depend on the characteristics of the employed polymer as well as the fabrication parameters such as applied electrical field, solution viscosity, and the injection flow rate [19] . Electrospun sheets have been used for different applications including tissue engineering and drug delivery as various drugs can be loaded into the prepolymer before the electrospinning process to have a controlled release [20] . Here, we utilized electrospun elastic sheets of poly(caprolactone)-poly(glycerol sebacate) (PGS-PCL) substrates for engineering stretchable and biodegradable electronics (Figure 1a).…”

mentioning

confidence: 99%

Biodegradable Nanofibrous Polymeric Substrates for Generating Elastic and Flexible Electronics

et al. 2014

View full text Add to dashboard Cite

Biodegradable nanofibrous polymeric substrates are used to fabricate suturable, elastic, and flexible electronics and sensors. The fibrous microstructure of the substrate makes it permeable to gas and liquid and facilitates the patterning process. As a proof‐of‐principle, temperature and strain sensors are fabricated on this elastic substrate and tested in vitro. The proposed system can be implemented in the field of bioresorbable electronics and the emerging area of smart wound dressings.

show abstract

“…This material is available free of charge via the Internet at http://pubs.acs.org. 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 ACS Paragon Plus Environment …”

Section: Supporting Information (Si)mentioning

confidence: 99%

Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

et al. 2016

View full text Add to dashboard Cite

Intermolecular interaction phenomena occurring between endogenous compounds, such as proteins and bile salts, and electrospun compounds are so far unreported, despite the exposure of fibers to such biorelevant compounds when applied for biomedical purposes, e.g., tissue engineering, wound healing, and drug delivery. In the present study, we present a systematic investigation of how surfactants and proteins, as physiologically relevant components, interact with insulin-loaded fish sarcoplasmic protein (FSP) electrospun fibers (FSP-Ins fibers) in solution and thereby affect fiber properties such as accessible surface hydrophilicity, physical stability, and release characteristics of an encapsulated drug. Interactions between insulin-loaded protein fibers and five anionic surfactants (sodium taurocholate, sodium taurodeoxycholate, sodium glycocholate, sodium glycodeoxycholate, and sodium dodecyl sulfate), a cationic surfactant (benzalkonium chloride), and a neutral surfactant (Triton X-100) were studied. The anionic surfactants increased the insulin release in a concentration-dependent manner, whereas the neutral surfactant had no significant effect on the release. Interestingly, only minute amounts of insulin were released from the fibers when benzalkonium chloride was present. The FSP-Ins fibers appeared dense after incubation with this cationic surfactant, whereas high fiber porosity was observed after incubation with anionic or neutral surfactants. Contact angle measurements and staining with the hydrophobic dye 8-anilino-1-naphthalenesulfonic acid indicated that the FSP-Ins fibers were hydrophobic, and showed that the fiber surface properties were affected differently by the surfactants. Bovine serum albumin also affected insulin release in vitro, indicating that also proteins may affect the fiber performance in an in vivo setting.

show abstract

Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres

Cited by 33 publications

References 30 publications

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Biodegradable Nanofibrous Polymeric Substrates for Generating Elastic and Flexible Electronics

Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

Contact Info

Product

Resources

About