Pulsatile flow is not a magic bullet for congenital heart surgery patients during CPB procedures

Ündar, Akif; Moroi, Morgan K.

doi:10.1111/aor.13511

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Furthermore, neuromonitoring technicians play a critical role when it comes to assessing the safety of pulsatile flow in the operating room. Nonetheless, despite having shown to minimize vital organ injury 30–33 , pulsatile flow has not consistently correlated with improved clinical outcomes and thus is not a magic bullet for congenital cardiac surgery patients during CPB procedures 34 . In order to end this controversy, multicenter double-blinded randomized clinical trials are recommended.…”

Section: The Cbp Circuitmentioning

confidence: 99%

Impact of a Multidisciplinary Research Team Approach to Prevent Avoidable Mistakes for Neonatal CPB Population

Patel

Ündar

2022

World J Pediatr Congenit Heart Surg

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Significant progress has been made in neonatal cardiopulmonary bypass (CPB) over the years. At Penn State Health Children’s Hospital, we have established a multidisciplinary research team that brings clinicians, engineers, scientists, research nurses, neuromonitoring technicians, perfusionists, and students from various departments to help reduce adverse outcomes following CPB in neonates. With the help of this team, we evaluate each CPB component in simulated conditions identical to those used in clinical practice. The objective of this review is to demonstrate the results of these translational projects and present critical mistakes to avoid for neonatal CPB patients.

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Section: The Cbp Circuitmentioning

confidence: 99%

Impact of a Multidisciplinary Research Team Approach to Prevent Avoidable Mistakes for Neonatal CPB Population

Patel

Ündar

2022

World J Pediatr Congenit Heart Surg

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“…Therefore, translational research studies are required to do additional validation and pre-clinical safety protocols for hemodynamic parameters and microemboli generation and delivery during CPB procedures. [2][3][4] It is also documented that the manufacturer's recommended maximum blood flow rates of the oxygenators may be exceeded under pulsatile perfusion. 5 Therefore, pre-clinical circuit optimization and validation are required.…”

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confidence: 99%