Pulsatile Versus Nonpulsatile Flow During Cardiopulmonary Bypass: Microcirculatory and Systemic Effects

O’Neil, Michael; Fleming, Jennifer C.; Badhwar, Amit; Guo, Lina

doi:10.1016/j.athoracsur.2012.05.065

Cited by 155 publications

(131 citation statements)

References 30 publications

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“…Pulsatile flow is believed to improve renal function by decreasing peripheral vascular resistance, optimizing microcirculation and decreasing tissue edema [120,121] . However, the inconsistent results of studies cannot support its routine use for protection against CSA-AKI [122][123][124] .…”

Section: Cpb Flowmentioning

confidence: 99%

Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury

Najafi

2014

WJC

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Serum creatinine is still the most important determinant in the assessment of perioperative renal function and in the prediction of adverse outcome in cardiac surgery. Many biomarkers have been studied to date; still, there is no surrogate for serum creatinine measurement in clinical practice because it is feasible and inexpensive. High levels of serum creatinine and its equivalents have been the most important preoperative risk factor for postoperative renal injury. Moreover, creatinine is the mainstay in predicting risk models and risk factor reduction has enhanced its importance in outcome prediction. The future perspective is the development of new definitions and novel tools for the early diagnosis of acute kidney injury largely based on serum creatinine and a panel of novel biomarkers.

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Section: Cpb Flowmentioning

confidence: 99%

Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury

Najafi

2014

WJC

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“…Blood flow in microcirculation is pulsatile in terms of pressure and pulse wave velocity (PWV) [43], in which pulsatility has wide-ranging physiological consequences [44][45][46], and non-pulsatile flow is observed to be related to dysfunctions of micro-vascular systems [47][48][49]. Compared with steady models of microcirculation that are based on steady state concepts [50][51][52], dynamic models [53,54] may be capable of exploring pulse wave propagation in microcirculation.…”

Section: One-dimensional Model For the Mvsmentioning

confidence: 98%

Multi-scale modeling of hemodynamics in the cardiovascular system

Liang

Wong

et al. 2015

Acta Mech. Sin.

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The human cardiovascular system is a closedloop and complex vascular network with multi-scaled heterogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arterial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study: recent progress of patient-specific hemodynamic modeling in clinical applications, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynamic modeling.

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“…On the contrary, a pulsatile flow, during CPB, reduces vasoconstrictive reflexes, optimises oxygen consumption and decreases acidosis [59]. Microemboli and hypothermia can be involved significantly in the genesis of AKI.…”

Section: Renal Effects Of Cpbmentioning

confidence: 99%