Pulse Wave Velocity and Lipid Profile in Varicose Vein Patients

Reghunandanan, R; Sood, Sandeep; Reghunandanan, V; Nagpaul, Ravi; Suresh, Padmanaban S.; Singh, Pardaman I.

doi:10.1177/000331979504600507

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…There is at least one study which reported abnormal clot lysis time in persons with varicose veins, and speculated about the role of the relative proportions of long-chain versus short-chain fatty acids in the diet [12]. However, a study on the lipid profile among subjects with varicose veins and their controls showed no difference between the two groups [66].…”

Section: Long Hours Of Standing Have Anecdotally Been Associated With Varicose Veins and The Debate Aboutmentioning

confidence: 99%

The Epidemiology of Chronic Venous Diseases

et al. 2000

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Objective: To review the prevalence of and risk factors for varicose veins, chronic venous insufficiency (CVI) and venous leg ulcers. Data sources: MEDLINE was searched for the terms prevalence and varicose veins, chronic venous insufficiency, or venous leg ulcers. Study selection: The extant world literature (1966–1999) with a minimum of an available English abstract was collected. Ninety-nine studies were reviewed. Data extraction: Data were extracted on prevalence of diseases of the veins in the lower limb, age and gender of the subject populations, and other risk factors for those diseases examined by the original researchers. Data synthesis: The two most prominent risk factors for venous disease are increasing age and female gender. Additional risk factors for venous disease with at least some documentation in the literature include dietary patterns, obesity, physical activity, standing occupations, constrictive clothing, connective tissue laxity, and hormonal differences, including pregnancy. Family history is also a prominent risk factor, suggesting a genetic component. Conclusions: Varicose veins are found more commonly in women, and with increased age. The increase with age is linear, suggesting a constant incidence and cumulative prevalence. CVI is also more common in women and increases with age, but data are limited. Venous leg ulcers are much less common than varicose veins or CVI and show less of a female preponderance, but increase exponentially with age, suggesting a true increasing incidence with age.

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Section: Long Hours Of Standing Have Anecdotally Been Associated With Varicose Veins and The Debate Aboutmentioning

confidence: 99%

The Epidemiology of Chronic Venous Diseases

et al. 2000

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“…3-6,16-23 Although multivariate analyses in these studies have shown a strong association between age and PWV, the studies relating PWV to cholesterol and/or dyslipidemia found minimal or inconsistent correlations. [4][5][6]16,17 Furthermore, several studies differ in their conclusions regarding the association between other risk factors and PWV.3,18-23 These inconclusive results may have resulted in part from the fact that most studies were cross-sectional studies. Furthermore, because most individuals have 1 or more cardiovascular risk factors or a cluster of features of the metabolic syndrome (MS) (i.e., obesity, glucose metabolism disturbances, abnormal lipids, and high blood pressure), a clinical condition that seems to be mediated by insulin resistance, 24-27 it may not be appropriate to look only at isolated components.…”

Section: Introductionmentioning

confidence: 99%

Clustered Features of the Metabolic Syndrome and the Risk for Increased Aortic Pulse Wave Velocity in Middle-aged Japanese Men

Nakanishi¹,

Suzuki²,

Tatara³

2003

Angiology

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The association between different features of the metabolic syndrome (MS) (obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol level, hypertriglyceridemia, high fasting plasma glucose level, and hyperuricemia) and the risk for increased aortic pulse wave velocity (PWV) of > or = 8.0 m/sec was examined in 2431 Japanese men aged 35 to 54 years who were not taking antihypertensive medication. After controlling for age, cigarette smoking, and alcohol intake, the odds ratios for increased aortic PWV in subjects with 1, 2, 3, and > or = 4 features of the MS, compared with those without features of the MS, were 1.35 (95% CI, 0.86 to 2.11), 1.90 (95% CI, 1.18 to 3.06), 1.57 (95% CI, 0.89 to 2.76), and 2.38 (95% CI, 1.26 to 4.49), respectively (p for trend = 0.003). A 9-year longitudinal study was also performed to prospectively examine the association between clustered features of the MS and the development of increased aortic PWV in 2073 men without aortic stiffness with a PWV < 8.0 m/sec and without antihypertensive medication during the follow-up period. The multivariate-adjusted hazard ratios for the incidence of increased aortic PWV in subjects with 1, 2, 3, and > or = 4 features of the MS, compared with those without features of the MS, were 1.39 (95% CI, 1.10 to 1.77), 1.46 (95% CI, 1.1 1 to 1.92), 1.75 (95% CI, 1.27 to 2.40), and 2.22 (95% CI, 1.52 to 3.25), respectively (p for trend < 0.001). These results suggest that clustered features of the MS are closely associated with the risk for increased aortic PWV in middle-aged Japanese men.

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“…Weitere allgemeine Einflussfaktoren wie sozialer Status, die Einnahme von oralen Antikontrazeptiva, geringe physische Aktivität, chronische Obstipation, steigende Körpergröße und -gewicht, Arthrose sowie Alkoholkonsum und Rauchen werden teilweise kontrovers diskutiert. Auch Zusammenhänge mit Erkrankungen des arteriellen Gefäßsystems, wie Bluthochdruck und Arteriosklerose werden beschrieben (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Risikofaktorenunclassified

Berufsgruppen- und altersabhängige Unterschiede in der Arbeitsunfähigkeit durch Varizen der unteren Extremitäten

et al. 2019

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Zusammenfassung Hintergrund/Zielsetzung Arbeitsunfähigkeit (AU) durch Venenerkrankungen ist relativ häufig. Sie ist bei Erwerbstätigen abhängig von der beruflichen Tätigkeit. Es soll geklärt werden, ob berufsspezifische Unterschiede im Auftreten von AU-Ereignissen aufgrund der ICD 10-Diagnose „Varizen der unteren Extremitäten“ zudem abhängig vom Lebensalter sind. Methodik Die Untersuchung basiert auf einer Sekundärdatenanalyse von AU-Daten fast aller gesetzlichen Krankenkassen Deutschlands des Jahres 2008. Es liegen geschlechtsstratifizierte, aggregierte Daten von 26,2 Mio. gesetzlich pflichtversicherten Erwerbstätigen vor. Berechnet werden AU-Fallzahlen stratifiziert nach Geschlecht und Alter sowie indirekt standardisierte Morbiditätsratios für das Auftreten von AU-Fällen nach Alter und Berufsgruppen stratifiziert. Ergebnis Beschäftigte in Produktionsberufen mit geringem und mittlerem Qualifikationsniveau sind aufgrund von Varizen besonders häufig arbeitsunfähig. In beiden Geschlechtern treten in allen Altersgruppen mindestens anderthalbmal so viele AU-Fälle wie bei qualifizierten kaufmännischen und Verwaltungsberufen (Referenzgruppe) auf. In der Altersgruppe der 35- bis 44-Jährigen sind Beschäftigte in gering qualifizierten Verwaltungsberufen ebenfalls anderthalbmal häufiger arbeitsunfähig als in der Referenzgruppe. Variationen der Effekte über das Lebensalter sind nachweisbar. Diskussion/Zusammenfassung Da in Zukunft mehr ältere Erwerbstätige zu erwarten sind (Verschiebung des Rentenalters, bessere medizinische Versorgung, Erhöhung des Anteils der Erwerbstätigkeit bei Älteren), sollte die Prävention im Betrieb (z. B. im Rahmen der arbeitsmedizinischen Vorsorge) verstärkt werden. Ein besonderer Schwerpunkt sollte in Produktionsberufen sowie grundsätzlich in Berufen mit geringer Qualifikation liegen.

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Pulse Wave Velocity and Lipid Profile in Varicose Vein Patients

Cited by 8 publications

References 20 publications

The Epidemiology of Chronic Venous Diseases

The Epidemiology of Chronic Venous Diseases

Clustered Features of the Metabolic Syndrome and the Risk for Increased Aortic Pulse Wave Velocity in Middle-aged Japanese Men

Berufsgruppen- und altersabhängige Unterschiede in der Arbeitsunfähigkeit durch Varizen der unteren Extremitäten

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