Pulsed Electromagnetic Field (PEMF) Treatment Reduces Lipopolysaccharide-Induced Septic Shock in Mice

Abstract

Despite advances in medicine, mortality due to sepsis has not decreased. Pulsed electromagnetic field (PEMF) therapy is emerging as an alternative treatment in many inflammation-related diseases. However, there are few studies on the application of PEMF therapy to sepsis. In the current study, we examined the effect of PEMF therapy on a mouse model of lipopolysaccharide (LPS)-induced septic shock. Mice injected with LPS and treated with PEMF showed higher survival rates compared with the LPS group. The increased survival was correlated with decreased levels of pro-inflammatory cytokine mRNA expression and lower serum nitric oxide levels and nitric oxide synthase 2 mRNA expression in the liver compared with the LPS group. In the PEMF + LPS group, there was less organ damage in the liver, lungs, spleen, and kidneys compared to the LPS group. To identify potential gene targets of PEMF treatment, microarray analysis was performed, and the results showed that 136 genes were up-regulated, and 267 genes were down-regulated in the PEMF + LPS group compared to the LPS group. These results suggest that PEMF treatment can dramatically decrease septic shock through the reduction of pro-inflammatory cytokine gene expression. In a clinical setting, PEMF may provide a beneficial effect for patients with bacteria-induced sepsis and reduce septic shock-induced mortality.

A Review - Does Low Magnitude High-Frequency Vibration (LMHFV)Worth for Fracture Recovery Compared with Pulsed Electromagnetic Field (PEMF) Based Magnetotherapy Method?

“…The rapid fracture healing rate will decrease the implant failure rate. Based on the primary findings and additional metrics, the results suggest that immediate treatment of LMHFV to the fracture site stimulates bone production and healing better than PEMF application [24][25][26][27][28][29][30][31]. Vibration therapy may hasten fractures' healing by encouraging calluses' growth.…”

“…They had a significantly higher BV/TV ratio than the control group (p = 0.01). This progress indicates that HF-PEMF treatment aids bone healing more quickly [13][14][15][16][21][22][23][24][25][26][27][28][29][30][31][32]. For two weeks after surgery, HF-PEMFs were applied daily for 10 minutes to rats.…”

“…PEMF (Pulsed Electromagnetic Field) is a method of fracture healing process based on electromagnetic fields. The Helmholtz coil used in the electromagnetic field test has a magnetic field value influenced by the current and the amount of turns, which is related to the fracture healing process [31,32]. According to Hasmia et al, coil diameters affect current fluctuation, distance variations, and magnetic field changes that rely on the number of coils [33].…”

Pulsed Electromagnetic Field (PEMF) Treatment Ameliorates Murine Model of Collagen-Induced Arthritis

“…In a previous study, we demonstrated the protective effects of PEMF treatment on septic shock mortality in an LPS-induced murine sepsis model [ 49 ]. This study showed that PEMF can also ameliorate both chronic autoimmune disease and acute inflammatory responses.…”

Bioelectricity in dental medicine: a narrative review

“…Furthermore, volt per meter (V/m) and ampere per square meter (A/m 2 ) were considered as better units to evaluate intensity because they considering the volume and cross-section area of tissue [ 191 ]. In the context of PEMF, Gauss is the most frequently used unit to describe the magnitude of EStim [ 192 , 193 ]. Hence, in future research, it is imperative to establish a universally recognized unit for describing the magnitude of electric fields within tissues.…”