Mastitis is inflammation of animals udder or mammary gland occur due to bacterial invasion followed by injury and it is the infectious zoonotic disease caused by the consumption of raw milk. Consumption of this raw milk led to many zoonotic diseases like bovine tuberculosis, listeriosis, brucellosis, Q fever, salmonellosis, leptospirosis and mycoplasma infections. Bovine tuberculosis in mammals caused by Mycobacterium bovis and it primarily affect upper and lower respiratory tract. Listeriosis is caused by listeria monocytogenes and it mainly cause damage to the CNS of animal. Q fever caused by coxialla burnetti which is highly resistant to environment and more dangerous for pregnant animals and cause pre mature birth or abortion and human get infection by respiratory route. Salmonellosis is caused by bacteria of the genus Salmonella belongs to the family Enterobacteriaceae and affect broad host spectrum. Salmonella is the major cause of intestinal infection in many hosts. Raw milk and milk products and uncooked meat is the main cause of these infections. These results in great economical loses and preventer by taking hygienic measures and consumption of properly cooked meat and pasteurized milk.