Pulsed Light Irradiation Improves Behavioral Outcome in a Rat Model of Chronic Mild Stress

Wu, Xingjia; Alberico, Stephanie L.; Moges, Helina; Taboada, Luis De; Tedford, Clark E.; Anders, Juanita J.

doi:10.1002/lsm.22004

Cited by 46 publications

(31 citation statements)

References 35 publications

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“…Recently, transcranial NIR PBM therapy has been suggested as a non-invasive neurostimulation modality in the central nervous system and is emerging as a novel promising treatment to defeat depression (Caldieraro et al, 2018; Cassano et al, 2015; Cassano et al, 2016; Salehpour and Rasta, 2017). Previous reports from our laboratory and others have shown that repeated delivery of NIR laser therapy produces an antidepressant-like effect in the FST (Mohammed, 2016; Salehpour et al, 2016; Wu et al, 2012; Xu, et al, 2017) and TST (Xu, et al, 2017). Nevertheless, in the current study, we showed that transcranial NIR PBM therapy for 5 days produced a notable antidepressant-like effect, as indicated by shorter immobility time in the FST and TST.…”

Section: Discussionmentioning

confidence: 73%

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Salehpour

Farajdokht

Cassano

et al. 2019

Brain Research Bulletin

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This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q10 (CoQ10) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive-like model, mice were subjected to sub-chronic restraint stress for 5 consecutive days. NIR PBM (810 nm laser, 33.3 J/cm2) and/or CoQ10 (500 mg/kg/day, gavage) were administered for five days concomitantly with immobilization. Behavior was evaluated by the forced swim test (FST), tail suspension test (TST), and open field test (OFT). Mitochondrial membrane potential as well as oxidative stress, neuroinflammatory, and markers of apoptosis were evaluated in the prefrontal cortex (PFC) and hippocampus (HIP). The serum levels of pro-inflammatory cytokines, cortisol, and corticosterone were also measured. PBM or CoQ10, or the combination, ameliorated depressive-like behaviors induced by restraint stress as indicated by decreased immobility time in both the FST and TST. PBM and/or CoQ10 treatments decreased lipid peroxidation and enhanced total antioxidant capacity (TAC), GSH levels, GPx and SOD activities in both brain areas. The neuroinflammatory response in the HIP and PFC was suppressed, as indicated by decreased NF-kB, p38, and JNK levels in PBM and/or CoQ10 groups. Intrinsic apoptosis biomarkers, BAX, Bcl-2, cytochrome c release, and caspase-3 and −9, were also significantly down-regulated by both treatments. Furthermore, both treatments decreased the elevated serum levels of cortisol, corticosterone, TNF-, and IL-6 induced by restraint stress. Transcranial NIR PBM and CoQ10 therapies may be effective antidepressant strategies for the prevention of psychopathological and behavioral symptoms induced by stress.

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Section: Discussionmentioning

confidence: 73%

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Salehpour

Farajdokht

Cassano

et al. 2019

Brain Research Bulletin

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“…Body weight has been viewed as a marker in depression study, and CMS causes about 0–10% loss of body weight [16]. However, some researches show that CMS rats have body weight gain and antidepressants, including Fluoxetine and clomipramine, have even less body weight than CMS and normal control group [7, 17]. A recent study also shows that EA treatment or EA combined with clomipramine has similar body weight gain to the CMS and control group [7].…”

Section: Discussionmentioning

confidence: 99%

Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats

Liu¹,

Sun³

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment of depression. The present study was conducted to explore the role of the cAMP cascade in antidepressant action of electroacupuncture (EA) treatment for chronic mild stress (CMS)-induced depression model rats. The results showed that EA improved significantly behavior symptoms in depression and dysfunction of AC-cAMP-PKA signal transduction pathway induced by CMS, which was as effective as fluoxetine. Moreover, the antidepressant effects of EA rather than Fluoxetine were completely abolished by H89, a specific PKA inhibitor. Consequently, EA has a significant antidepressant treatment in CMS-induced depression model rats, and AC-cAMP-PKA signal transduction pathway is crucial for it.

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“…[8][9][10] LLLT is also currently used for the treatment of various neurological diseases such as stroke, neurodegenerative diseases, and brain injury. [11][12][13][14][15][16] Several studies have shown that near-infrared LLLT has the potential to be an effective noninvasive therapy for SCI. [17][18][19][20] Rochkind et al demonstrated that transplantation of embryonal spinal cord nerve cells followed by 780-nm laser irradiation enhanced axonal sprouting and spinal cord repair in a completely transected rat SCI model.…”

Section: Introductionmentioning

confidence: 99%

Low-level laser therapy for spinal cord injury in rats: effects of polarization

et al. 2013

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Abstract. The effects of laser polarization on the efficacy of near-infrared low-level laser therapy for spinal cord injury (SCI) are presented. Rat spinal cords were injured with a weight-drop device, and the lesion sites were directly irradiated with a linearly polarized 808-nm diode laser positioned either perpendicular or parallel to the spine immediately after the injury and daily for five consecutive days. Functional recovery was assessed daily by an open-field test. Regardless of the polarization direction, functional scores of SCI rats that were treated with the 808-nm laser irradiation were significantly higher than those of SCI alone group (Group 1) from day 5 after injury. The locomotive function of SCI rats irradiated parallel to the spinal column (Group 3) was significantly improved from day 10 after injury, compared to SCI rats treated with the linear polarization perpendicular to the spinal column (Group 2). There were no significant differences in ATP contents in the injured tissue among the three groups. We speculate that the higher efficacy with parallel irradiation is attributable to the deeper light penetration into tissue with anisotropic scattering. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Pulsed Light Irradiation Improves Behavioral Outcome in a Rat Model of Chronic Mild Stress

Abstract: TLT was comparable to fluoxetine in improving the behavioral outcome after CMS. TLT did not cause weight loss, which is consistently seen in patients treated with fluoxetine. This study demonstrates that TLT has potential as an effective treatment for depression.

Cited by 46 publications

References 35 publications

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats

Low-level laser therapy for spinal cord injury in rats: effects of polarization

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