Pulsed Magnetic Field Therapy for Tibial Non-Union

Barker, Anthony T.; Dixon, R A; Sharrard, W. J. W.; Sutcliffe, M. L.

doi:10.1016/s0140-6736(84)92329-8

Cited by 138 publications

(37 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, even when comparing separate randomized, double-blinded, prospective studies involving large numbers of test subjects [28,36], there are conflicting interpretations of whether PEMF exhibits clinically significant improvements in new bone tissue production. Thus, despite its FDA approval for clinical use, PEMF treatment has not been widely accepted within the orthopaedic community because of this continuing debate regarding its clinically beneficial effects [7,43,36,28,5].…”

Section: Introductionmentioning

confidence: 99%

Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies

Midura

Ibiwoye

Powell

et al. 2005

Journal Orthopaedic Research

109

View full text Add to dashboard Cite

This study tested the hypothesis that pulsed electromagnetic field (PEMF) treatments augment and accelerate the healing of bone trauma. It utilized micro-computed tomography imaging of live rats that had received bilateral 0.2 mm fibular osteotomies (-0.5% acute bone loss) as a means to assess the in vivo rate dynamics of hard callus formation and overall callus volume. Starting 5 days post-surgery, osteotomized right hind limbs were exposed 3 h daily to Physio-Stim@ PEMF, 7 days a week for up to 5 weeks of treatment. The contralateral hind limbs served as sham-treated, within-animal internal controls. Although both PEMF-and sham-treatment groups exhibited similar onset of hard callus at -9days after surgery, a 2-fold faster rate of hard callus formation was observed thereafter in PEMF-treated limbs, yielding a 2-fold increase in callus volume by 13-20 days after surgery. The quantity of the new woven bone tissue within the osteotomy sites was significantly better in PEMF-treated versus sham-treated fibulae as assessed via hard tissue histology. The apparent modulus of each callus was assessed via a cantilever bend test and indicated a 2-fold increase in callus stiffness in the PEMF-treated over sham-treated fibulae. PEMF-treated fibulae exhibited an apparent modulus at the end of 5-weeks that was -80% that of unoperated fibulae. Overall, these data indicate that Physio-Stim@ PEMF treatment improved osteotomy repair. These beneficial effects on bone healing were not observed when a different PEMF waveform, Osteo-Stim@, was used. This latter observation demonstrates the specificity in the relationship between waveform characteristics and biological outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies

Midura

Ibiwoye

Powell

et al. 2005

Journal Orthopaedic Research

109

View full text Add to dashboard Cite

show abstract

“…20,31 Thus, 27 trials were included in our review: 12 evaluating LIPUS [32][33][34][35][36][37][38][39][40][41][42] and 15 evaluating ESTIM. 20,31,[43][44][45][46][47][48][49][50][51][52][53][54][55] There was perfect agreement between reviewers in the full text review stage. Table 1 describes the trials included in our review.…”

Section: Study Selectionmentioning

confidence: 97%

“…Table 1 describes the trials included in our review. Eight trials evaluating LIPUS (7 fresh fracture and 1 nonunion populations), [32][33][34][37][38][39]41 and 7 trials evaluating ESTIM (3 fresh fracture and 5 nonunion populations), 43,44,49,[52][53][54] reported union rates as one of their outcomes and were used in the network meta-analyses. Fig.…”

Section: Study Selectionmentioning

confidence: 99%

“…Adie et al 43 Barker et al 44 Beck et al 45 Betti et al 46 Borsalino et al 47 Emami et al 32 Eyres et al 48 Faldini et al 49 Handolin et al 33 Handolin et al 34 Hanneman et al 20 Heckman et al 35 Kristiansen et al 36 Leung et al 37 Lubbert et al 38 Mammi et al 50 Mayr et al 39 Poli et al 51 Ricardo 22 Rue et al 40 Scott et al 52 Sharrard 53 Shi et al 31 Simonis et al 54 Strauss et al 41 Wahlström 55 Yadav et al …”

Section: Effect Of Lipus On Rate Of Fracture Unionmentioning

confidence: 99%

See 1 more Smart Citation

Low-intensity pulsed ultrasonography versus electrical stimulation for fracture healing: a systematic review and network meta-analysis

et al. 2014

View full text Add to dashboard Cite

Background:To best inform evidence-based patient care, it is often desirable to compare competing therapies. We performed a network meta-analysis to indirectly compare low intensity pulsed ultrasonography (LIPUS) with electrical stimulation (ESTIM) for fracture healing. Methods:We searched the reference lists of recent reviews evaluating LIPUS and ESTIM that included studies published up to 2011 from 4 electronic databases. We updated the searches of all electronic databases up to April 2012. Eligible trials were those that included patients with a fresh fracture or an existing delayed union or nonunion who were randomized to LIPUS or ESTIM as well as a control group. Two pairs of reviewers, independently and in duplicate, screened titles and abstracts, reviewed the full text of potentially eligible articles, extracted data and assessed study quality. We used standard and network meta-analytic techniques to synthesize the data. Results:Of the 27 eligible trials, 15 provided data for our analyses. In patients with a fresh fracture, there was a suggested benefit of LIPUS at 6 months (risk ratio [RR] 1.17, 95% confidence interval [CI] 0.97-1.41). In patients with an existing nonunion or delayed union, ESTIM had a suggested benefit over standard care on union rates at 3 months (RR 2.05, 95% CI 0.99-4.24). We found very low-quality evidence suggesting a potential benefit of LIPUS versus ESTIM in improving union rates at 6 months (RR 0.76, 95% CI 0.58-1.01) in fresh fracture populations. Conclusion:To support our findings direct comparative trials with safeguards against bias assessing outcomes important to patients, such as functional recovery, are required.Contexte : Pour mieux orienter les soins fondés sur des données probantes, il est souvent souhaitable de comparer des traitements entre eux. Nous avons procédé à une méta-analyse réseau pour comparer indirectement l'effet des ultrasons pulsés de faible intensité (UPFI) et de l'électrostimulation (ÉS) sur la guérison des fractures.Méthodes : Nous avons interrogé les listes bibliographiques de revues récentes ayant évalué les UPFI et l'ÉS, en incluant des études publiées jusqu'en 2011 à partir de 4 bases de données électroniques. Nous avons actualisé les interrogations de toutes les bases de données électroniques jusqu'à avril 2012. Les essais admissibles étaient ceux qui incluaient des patients victimes d'une fracture récente ou présentant un retard de soudure ou une non soudure de fracture ayant été assignés aléatoirement aux UPFI ou à l'ÉS ou à un groupe témoin. Deux paires d'examinateurs ont passé en revue indépendamment et en duplicata les titres, les résumés et les textes complets des articles potentiellement admissibles. Ils en ont extrait les données et ont évalué la qualité des études. Nous avons utilisé des techniques de méta-analyse standard et réseau pour synthétiser les données.Résultats : Parmi les 27 essais admissibles, 15 ont fourni des données pour notre analyse. Chez les patients présentant une fracture récente, les UPFI auraient produit un avantag...

show abstract

“…There are also problems of reproducibility of reported effects. The therapeutic potential of ELF can be seen in the proven efficacy of low-energy, pulsed magnetic fields in non union bone fracture healing (Barker et al, 1984), confirming that under certain conditions non ionizing electromagnetic energy can influence physiological processes in organisms (Kaiser, 1988). Physiological paradigms for ELF effects are required.…”

Section: Discussionmentioning

confidence: 88%

Calcium Ion Cyclotron Resonance (ICR) Transfers Information to Living Systems: Effects on Human Epithelial Cell Differentiation

Lisi

Ledda

Carlo

et al. 2008

Electromagnetic Biology and Medicine

View full text Add to dashboard Cite

The specific aim of the present work concerns the effectiveness of low-frequency electromagnetic fields treatment to modify biochemical properties of human keratinocytes (HaCaT). Cells exposed to a 7 Hz electromagnetic field, tuned to calcium ion cyclotron resonance (ICR), showed modifications in the cytoskeleton. These modifications were related to different actin distributions as revealed by phalloidin fluorescence analysis. Indirect immunofluorescence with fluorescent antibodies against involucrin and beta catenin, both differentiation and adhesion markers, revealed an increase in involucrin and beta-catenin expression, indicating that exposure to electromagnetic field carries keratinocytes to an upper differentiation level. This study confirms our previous observation and supports the hypothesis that a 7 Hz calcium ICR electromagnetic field may modify cell biochemistry and interfere in the differentiation and cellular adhesion of normal keratinocytes, suggesting the possibility to use ICR electromagnetic therapy for the treatment of undifferentiated diseases.

show abstract

Pulsed Magnetic Field Therapy for Tibial Non-Union

Cited by 138 publications

References 9 publications

Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies

Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies

Low-intensity pulsed ultrasonography versus electrical stimulation for fracture healing: a systematic review and network meta-analysis

Calcium Ion Cyclotron Resonance (ICR) Transfers Information to Living Systems: Effects on Human Epithelial Cell Differentiation

Contact Info

Product

Resources

About