Punica granatum peel extract as adjunct irrigation to nonsurgical treatment of chronic gingivitis

Eltay, Eiba G.; Gismalla, Bakri G.; Mukhtar, Maowia M.; Awadelkarim, Mona O.A.

doi:10.1016/j.ctcp.2021.101383

Cited by 20 publications

(8 citation statements)

References 16 publications

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“…Almost all medicinal plants, like leaves, seeds, fruits, bark, stems, and roots, have been used for research purposes. [ 17 18 ] Table 3 illustrates the conclusive research remarks published recently from 2010 to 2022. [ 7 8 9 10 11 12 13 14 15 16 17 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

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Role of medicinal herbs in periodontal therapy: A systematic review

Pasupuleti¹,

Nagate²,

Alqahtani³

et al. 2023

JISPCD

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A BSTRACT Aims and Objectives: The use of medicinal herbs to prevent gingival and periodontal diseases has become increasingly popular due to their anti-inflammatory and antioxidant properties. This systematic review aims to provide the current literature to validate the traditional use of medicinal herbs in the management of gingival and periodontal diseases. Materials and Methods: An online literature search was conducted to identify research papers published from 2010 to 2022 in three major scientific databases, PubMed, Scopus, and Web of Science, in June 2022. Original research studies, case reports, and systematic reviews on medicinal plants’ application in oral health care were selected to be included in this systematic review. Only high-quality articles identified in the quality assessment were included for evidence synthesis. Results: Initial keyword research yielded 726 free-text articles published between 2010 and 2022. Of these, 14 articles (8 research papers and 6 reviews) were included for evidence synthesis. The review’s findings indicate that the antibacterial property of medicinal plants is due to their alkaline nature and prevents plaque and calculus formation by maintaining acid–alkali balance in saliva. Various parts of medicinal plants help maintain periodontal health. Glycyrrhiza glabra , Ficus religiosa , and Plantago major effectively inhibit primary plaque colonizers and periodontal pathogens. Medicago sativa , Aloe barbadensis Miller, and Trifolium pratense have excellent applications in treating periodontal diseases. Mangifera indica , Pongamia pinnata , the husk of Cocos nucifera , the root of G. glabra and Curcuma longa , leaves of Psidium guajava and Azadirachta indica , fruits of Citrus medica and Punica granatum , Ocimum Moringa oleifera extract, and pomegranate peel extract can serve as a promising alternative in managing chronic gingivitis. Conclusion: The anti-inflammatory, antioxidant, antibacterial, and astringent action of extracts obtained from various parts of medicinal plants make them effective in reducing gingival and periodontal diseases. Herbal medicine may be a viable alternative to contemporary pharmaceuticals as an adjuvant to scaling and root planning procedures.

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Section: Discussionmentioning

confidence: 99%

“…[ 17 18 ] Table 3 illustrates the conclusive research remarks published recently from 2010 to 2022. [ 7 8 9 10 11 12 13 14 15 16 17 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

Role of medicinal herbs in periodontal therapy: A systematic review

Pasupuleti¹,

Nagate²,

Alqahtani³

et al. 2023

JISPCD

View full text Add to dashboard Cite

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“…5% Punica granatum peel extract decreases chronic gingivitis' clinical signs and IL-1β levels without any adverse effect. Punica granatum chip may increase the effectiveness of conventional therapies and used in adjunction to scaling and root planning proves to be more effective than traditional management alone [99].…”

Section: Pomegranate (Punica Granatum)mentioning

confidence: 99%

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

Gościniak

Paczkowska-Walendowska

Skotnicka

et al. 2021

Pharmaceutics

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Periodontal diseases are one of the most significant challenges in dental health. It is estimated that only a few percent of the worldwide population have entirely healthy teeth, and according to WHO, oral diseases may affect up to 3.5 billion people worldwide. One of the most serious oral diseases is periodontitis, an inflammatory disease affecting periodontal tissues, caused by pathogenic bacteria and environmental factors such as the ageing population, abuse of tobacco products, and lack of adequate oral hygiene due low public awareness. Plant materials are widely and successfully used in the management of many conditions, including periodontitis. Plant materials for periodontitis exhibit antibacterial, anti-inflammatory, antioxidant activities and affect the periodontium structure. Numerous studies demonstrate the advantages of phytotherapy for periodontitis relief and indicate the usefulness of Baikal skullcap root, Pomegranate fruit peel and root cortex, Tea leaves, Chamomile flowers, Magnolia bark, Blackberry leaves and fruits, Cranberry fruits and Lippia sidoides essential oil. This review aims to analyze the use and applicability of selected plant materials in periodontitis management since it is of paramount importance to evaluate the evidence of the traditionally used plant materials in light of continuously growing interest in phytotherapy and its adjuvant role in the treatment of periodontitis.

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“…However, all the parts of the Punica granatum have been used for therapeutic purposes: leaves, flowers, bark, roots, peel, juice, seeds; their uses find application as anti-inflammatories [ 3 ], analgesics [ 4 ], in the management of postmenopausal symptoms, being weakly estrogenic [ 5 ], but also in erectile dysfunction, in diabetes [ 6 , 7 , 8 ] and cardiovascular disease [ 9 ], in the treatment of arthritis [ 10 ] and in Alzheimer’s disease [ 11 ]; it also has bactericidal [ 12 ], antifungal [ 13 ] and antiviral properties [ 14 ]; its use in chronic gingivitis has also been evaluated in the dental field [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review

et al. 2022

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The Punica granatum L. is an ancient fruit plant native to south-western Asia. It belongs to the Litraceae family and of its genus we have only one other Punica protopunic species. The fruit is rich in polyphenols, whose extract is consumed as a food and is considered safe. In medicine, it is used for its antioxidant properties; it has a rich component of tannic polyphenols among which the most bioactive are: punicalagin (flavonoids) and anthocyanins (delphinidin, cyanidin, pelargonidin), which are found mainly in the skins and in the pericarp; however, all the parts of the Punica granatum are used for therapeutic purposes as anti-inflammatories and analgesics and in diabetes and cardio-vascular disease. Punica granatum extracts also show interesting anticancer activities in influencing tumorgenesis and angiogenesis and cell transformation and proliferation. The purpose of this scoping review is to summarize all the scientific evidence on the possible applications of Punica granatum extracts in the treatment and prevention of oral cavity tumors to investigate the anticancer properties of the active ingredients extracted from Punica granatum. Methods: The scoping review was carried out following the PRISMA-ScR checklist; the search was performed on three databases (Scopus, Science direct and PubMed) and one registry (Cochrane library). Results: The search produced a number of bibliographic sources equal to 11,403; with the removal of duplicates, 670 potentially admissible articles were obtained, from 24 of which only 7 in vitro studies on OSCC cell lines were included. Conclusions: From the preliminary data on the cellular lines of OSCC, it emerges that for oral cancer there are conditions for which the extracts of Punic granatum are effective at least from a prevention perspective.

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Punica granatum peel extract as adjunct irrigation to nonsurgical treatment of chronic gingivitis

Cited by 20 publications

References 16 publications

Role of medicinal herbs in periodontal therapy: A systematic review

Role of medicinal herbs in periodontal therapy: A systematic review

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review

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