Pup circadian rhythm entrainment—effect of maternal ganglionectomy or pinealectomy

Bellavía, S. L.; Carpentieri, Ágata Rita; Vaqué, A. M.; Macchione, Ana Fabiola; Vermouth, Nelia T.

doi:10.1016/j.physbeh.2006.06.018

Cited by 49 publications

(38 citation statements)

References 35 publications

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“…These effects of LL on the maternal SCN were prevented by maternal melatonin administration during the last period of gestation. Our results are consistent with previous studies (6,7,11,12,30), confirm the importance of the melatonin signal and provide evidence of the protective effects of the hormone on maternal programming during gestation.…”

Section: Discussionsupporting

confidence: 93%

“…Pups born to 15 mothers submitted to constant light during pregnancy, as described for the LL group, and injected subcutaneously (7,12) with a daily dose of melatonin (Mel, 1 mg/kg body weight, CT12) from the 17th to the 21st day of pregnancy, a period considered to be adequate to cause entrainment, as previously reported (6,12). LL causes a 6-fold decrease in mean plasma melatonin concentration in adult rats (20) and, under a light-dark cycle, the circulating plasma levels increase significantly from day 15 to reach the highest values on gestational day 21 (8).…”

Section: Animal Groupsmentioning

confidence: 99%

“…Hormone binding sites are identified in the suprachiasmatic nucleus (SCN) of a fetus from the 18th day of gestation (9). This melatonin path, which mediates interactions between maternal and fetal physiological functions, has been explored mostly in fetal and neonatal circadian rhythms (10)(11)(12).…”

mentioning

confidence: 99%

“…Lesion of the maternal SCN during early gestation prevents maternal synchronization of pup rhythms (18). The removal of the pineal gland or of both superior cervical ganglia before the 11th day of gestation also prevents maternal synchronization of testicular malate dehydrogenase (MDH) rhythm and daily drinking behavior in the offspring (11,12). These disruptions of circadian rhythms in the offspring are prevented by administration of melatonin to the mother during the last period of gestation (7,12).…”

mentioning

confidence: 99%

“…The removal of the pineal gland or of both superior cervical ganglia before the 11th day of gestation also prevents maternal synchronization of testicular malate dehydrogenase (MDH) rhythm and daily drinking behavior in the offspring (11,12). These disruptions of circadian rhythms in the offspring are prevented by administration of melatonin to the mother during the last period of gestation (7,12). It is known that chronic exposure of adult rats to constant light induces suppression of the circadian system (19).…”

mentioning

confidence: 99%

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Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation

Cisternas

Compagnucci

Conti

et al. 2010

Braz J Med Biol Res

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Section: Discussionsupporting

confidence: 93%

Section: Animal Groupsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation

Cisternas

Compagnucci

Conti

et al. 2010

Braz J Med Biol Res

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Circadian clocks during embryonic and fetal development

Serón-Ferré

Valenzuela

Torres-Farfán

2007

Birth Defects Research Pt C

103

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Circadian rhythmicity is a fundamental characteristic of organisms, which helps ensure that vital functions occur in an appropriate and precise temporal sequence and in accordance with cyclic environmental changes. Living beings are endowed with a system of biological clocks that measure time on a 24-hr basis, termed the circadian timing system. In mammals, the system is organized as a master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, commanding peripheral clocks located in almost every tissue of the body. At the cell level, interlocking transcription/translation feedback loops of the genes Bmal-1, Clock, Per1-2, and Cry1-2, named clock genes, and their protein products results in circadian oscillation of clock genes and of genes involved in almost every cellular function. During gestation, the conceptus follows a complex and dynamic program by which it is simultaneously fit to develop and live in a circadian environment provided by its mother and to prepare for the very different environment that it will experience after birth. It has been known for a number of years that the mother tells the fetus the time of day and season of the year, and that the fetus uses this information to set the phase of fetal and neonatal circadian rhythms. There is evidence that the maternal rhythm of melatonin is one of the time signals to the fetus. In the last few years, the study of the development of the circadian system has turned to the investigation of the oscillatory expression of clock genes and their possible role in development, and to answering questions on the organization of the fetal circadian system. Emerging evidence shows that clock genes are expressed in the oocyte and during early and late development in embryo/fetal organs in the rat and in a fetal primate. The data available raise the intriguing possibility that the fetal SCN and fetal tissues may be peripheral clocks commanded by separate maternal signals. The rapid methodological and conceptual advances on chronobiology may help to unravel how the developing embryo and fetus faces time in this plastic period of life.

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Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver

Houdek

Polidarová

Nováková

et al. 2014

Developmental Neurobiology

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The mammalian circadian system develops gradually during ontogenesis, and after birth, the system is already set to a phase of the mothers. The role of maternal melatonin in the entrainment of fetal circadian clocks has been suggested, but direct evidence is lacking. In our study, intact or pinealectomized pregnant rats were exposed to constant light (LL) throughout pregnancy to suppress the endogenous melatonin and behavioral rhythms. During the last 5 days of gestation, the rats were injected with melatonin or vehicle or were left untreated. After delivery, daily expression profiles of c-fos and Avp in the suprachiasmatic nuclei (SCN), and Per1, Per2, Rev-erbα, and Bmal1 in the liver were measured in 1-day-old pups. Due to the LL exposure, no gene expression rhythms were detected in the SCN of untreated pregnant rats or in the SCN and liver of the pups. The administration of melatonin to pregnant rats entrained the pups' gene expression profiles in the SCN, but not in the liver. Melatonin did not affect the maternal behavior during pregnancy. Vehicle injections also synchronized the gene expression in the SCN but not in the liver. Melatonin and vehicle entrained the gene expression profiles to different phases, demonstrating that the effect of melatonin was apparently not due to the treatment procedure per se. The data demonstrate that in pregnant rats with suppressed endogenous melatonin levels, pharmacological doses of melatonin affect the fetal clock in the SCN but not in the liver.

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Pup circadian rhythm entrainment—effect of maternal ganglionectomy or pinealectomy

Cited by 49 publications

References 35 publications

Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation

Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation

Circadian clocks during embryonic and fetal development

Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver

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