Pupillographic sleepiness testing in hypersomniacs and normals

Wilhelm, Helmut; Lüdtke, Holger; Wilhelm, Barbara

doi:10.1007/s004170050149

Cited by 69 publications

(49 citation statements)

References 12 publications

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“…Artifacts caused by factors such as eye movements or eye blinks were detected and removed automatically based on a physiological limit of the rate of change of pupil diameter, and an algorithm was run to substitute such interrupted recording values by linear interpolation. Details of this methodology have been validated and published in other reports [6,7].…”

Section: Pupillometrymentioning

confidence: 99%

“…The relative pupillary unrest index (RPUI) was also calculated by dividing the PUI by the baseline pupil diameter, i.e., the mean pupil diameter during the first segment (82 s) of the eight consecutive segments [7].…”

Section: Pupillometrymentioning

confidence: 99%

“…In the late 1990s, the pupillographic sleepiness test (PST) was developed using pupillometry for the quantitative assessment of PU [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Spontaneous pupillary oscillation in darkness has been recorded by infrared video pupillography to quantify daytime sleepiness both in healthy subjects, such as sleepdeprived subjects [8], truck drivers [9], physicians following night duty [10], and neurology residents after night shift [11], and in patients with sleep disorders [7,12,13] or neurological diseases, such as Parkinson's disease [14] or multiple sclerosis [15]. These studies proved that PU is a valid and objective indicator of reduced arousal and showed pupillometry to be a useful tool for the screening and measurement of alertness whenever this outcome is of interest and for the monitoring of treatment for sleep disorders or in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

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Association between pupillometric sleepiness measures and sleep latency derived by MSLT in clinically sleepy patients

Yamamoto

Kobayashi

Hori

et al. 2013

Environ Health Prev Med

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Objectives The multiple sleep latency test (MSLT) has been employed extensively in clinical and research settings as a gold standard for objectively measuring sleepiness. In a general population or in a variety of work settings, however, a more convenient, rapidly administered measuring method is preferable. We examined the potential utility of pupillometry by comparing its objective measures, pupillary unrest index (PUI) and relative pupillary unrest index (RPUI), with MSLT-derived sleep latency (SL). Methods The study cohort comprised 45 patients (39 males, 6 females, mean age 38.9 ± 11.3 years) referred to the Sleep Disorders Center for the two-nap SL test. SL was measured twice before noon, and pupillometric measurement was performed immediately before each SL test. Subjective sleepiness was measured by using the Epworth Sleepiness Scale (ESS). Results The association between PUI and SL was significant and far closer than that between RPUI and SL. A significant difference was observed between the two groups, based on each subject's experience of drowsy driving accidents over the past 3 years in the PUI and RPUI, as well as in SL. The subjective sleepiness measure, ESS, did not relate to any other physiological sleepiness measures.Conclusions In our study cohort, the pupillometric sleepiness measure, PUI, was significantly correlated with, and behaved in a manner equivalent to, MSLT-derived SL in clinically sleepy patients. However, several points remain to be carefully examined before applying pupillometry for screening sleepiness in a general population, or in occupational settings.

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Section: Pupillometrymentioning

confidence: 99%

Section: Pupillometrymentioning

confidence: 99%

“…In the late 1990s, the pupillographic sleepiness test (PST) was developed using pupillometry for the quantitative assessment of PU [6,7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between pupillometric sleepiness measures and sleep latency derived by MSLT in clinically sleepy patients

Yamamoto

Kobayashi

Hori

et al. 2013

Environ Health Prev Med

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“…Ein vielversprechendes Instrument zur vorrangigen Ermittlung der momentanen Schläfrigkeit und somit beeinträchtigten Fahreignung stellt der Pupillographische Schläfrigkeitstest (PST) dar [43]. Die Erfassung der für die Diagnose von Schlafstörungen interessanten gemittelten Tagesschläfrigkeit [34] ist zwar denkbar, soll in diesem Beitrag jedoch nicht weiter verfolgt werden.…”

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Nur valide oder auch akkurat?

et al. 2012

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ÜbersichtenSchläfrigkeit ist verantwortlich für etwa 10-20% aller tödlichen Unfälle im Straßenverkehr und besitzt somit eine hohe gesellschaftliche und volkswirtschaftliche Relevanz. Diese Public-Health-Perspektive ist jedoch nicht mit Fragestellungen der Fahrtauglichkeit zu verwechseln, also der Bestimmung des individuellen Risikos, unter hoher Schläfrigkeit tatsächlich auch zu verunglücken. Belastbare Quantifizierungen dieser individuellen Risikoperspektive konnten derzeitig noch nicht ermittelt werden. Erste Hinweise auf die zu erwartenden Größenordnungen des Risikos, im Zuge einer einzelnen Risikoexposition (z. [5,15,22,23,26,33,35,39]) und F subjektive Schläfrigkeitsskalen [19,28,38,39,40]. B

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The pupillographic sleepiness test in adults: Effect of age, gender, and time of day on pupillometric variables

Eggert

Sauter

Popp

et al. 2012

American J Hum Biol

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PUI and PD were found to decrease with increasing age. In addition, the present data show that nonreliable PST data occur more frequently in the elderly probably because of dry eyes, inadequate testing conditions, and technical resolution limitations. Thus, the PST results obtained here from elderly subjects are limited and have to be interpreted with caution. Additional research on elderly specific assessment tools is needed.

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Pupillographic sleepiness testing in hypersomniacs and normals

Abstract: This study showed that a pupillographic sleepiness test based on the evaluation of spontaneous pupillary changes in darkness is applicable in hypersomniacs and may facilitate therapy control, i.e. diagnostic grading by measuring daytime sleepiness objectively.

Cited by 69 publications

References 12 publications

Association between pupillometric sleepiness measures and sleep latency derived by MSLT in clinically sleepy patients

Association between pupillometric sleepiness measures and sleep latency derived by MSLT in clinically sleepy patients

Nur valide oder auch akkurat?

The pupillographic sleepiness test in adults: Effect of age, gender, and time of day on pupillometric variables

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