The Cubixx ® system seamlessly monitors the storage status of medicines by using wireless networks, enabling the return and lot exchange of medicines stored under non-room temperature conditions, which was generally impossible previously. To evaluate the availability of the Cubixx ® system, we surveyed recent trends in the Japanese pharmaceutical market, status of pharmaceutical purchases, and status of the use of the Cubixx ® system in Yokohama City University Hospital.The Japanese pharmaceutical market continued to grow from 2007 to 2019 (P < 0.001). There are 11 pharmaceutical therapeutic categories (hereinafter referred to as "correlated categories") that have a statistically positive correlation with the expansion of the total output (P < 0.001). In the targeted period, most medicines newly listed on the NIH price list (67.9%) belong to correlated categories, and the ratio of injection medicines stored at non-room temperature which are expensive has increased. 96.7% of A-ranked medicines with ABC analysis in Yokohama City University Hospital are injection medicines, which tend to be expensive and stored at non-room temperature. 85% of A-ranked items belong to correlated categories. Due to the use of the Cubixx ® system, the targeted medicines were never discarded during the targeted period. The total amount of returned medicines during the period accounted for 62.3% of the total. The recent Japanese pharmaceutical market has continued to grow, with the increase in newly released injection medications which belong to correlated categories, are stored at non-room temperature, and expensive. The Cubixx ® system may be useful in the inventory management of these medicines.