Pure mucinous carcinoma of the breast

Komenaka, Ian K.; El‐Tamer, Mahmoud; Troxel, Andrea B.; Hamele‐Bena, Diane; Joseph, Kathie‐Ann; Horowitz, Elizabeth; Ditkoff, Beth-Ann; Schnabel, Freya

doi:10.1016/j.amjsurg.2003.12.039

Cited by 89 publications

(65 citation statements)

References 11 publications

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“…Presumably one of the reasons might be that its mucinous content does not feel solid or firm upon examination [7]. Axillary lymph node involvement is rare and was detected in 12% of the patients in the review by Saverio et al [4] and 14% in the series by Komenaka et al [7]. An inverse trend was reported to exist between MUC2 expression and lymph node stage and vascular invasion status [9].…”

Section: Discussionmentioning

confidence: 95%

“…These findings may mislead physicians and give a benign impression. The combination of a relatively unsuspicious mammography finding and softness upon palpation may increase the incidence of delayed diagnosis [7]. We found 82% of patients had a palpable mass in their breast, perhaps a reflection of delayed presentation.…”

Section: Discussionmentioning

confidence: 96%

“…Mucinous carcinoma tends to grow slowly, but it can sometimes have reached a large size by the time of diagnosis. Presumably one of the reasons might be that its mucinous content does not feel solid or firm upon examination [7]. Axillary lymph node involvement is rare and was detected in 12% of the patients in the review by Saverio et al [4] and 14% in the series by Komenaka et al [7].…”

Section: Discussionmentioning

confidence: 98%

“…We found that the tumor size was T1 in 19 patients, T2 in 8 patients, and T3 in 1 patient. Previous studies found that the size can become very large but potentially not impact survival [7]. The volume of mucin contributes to an overestimation of tumor size, and thus early detection could contribute to the very good prognosis in PMBC [3].…”

Section: Discussionmentioning

confidence: 99%

“…The volume of mucin contributes to an overestimation of tumor size, and thus early detection could contribute to the very good prognosis in PMBC [3]. Previous report demonstrated that no correlation exists between tumor size and prognosis because the tumor size largely depends on the volume of extracellular mucin [7]. Mucins are a family of high-molecular weight, heavily glycosylated proteins [3].…”

Section: Discussionmentioning

confidence: 99%

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Pure Mucinous Breast Carcinoma: A Favorable Subtype

Yang

Chun-Hong

et al. 2013

Breast Care

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Background: Pure mucinous breast carcinoma is a relatively rare subtype of breast malignancy. This study is to investigate the clinical and pathologic features of pure mucinous breast carcinoma. Patients andMethods: A retrospective review of our database of patients who presented with breast cancer was performed. The medical records of 1,060 patients with invasive breast cancer who underwent surgery were reviewed. Results: 28 patients with pure mucinous breast cancer were identified. The mean age was 55.28 ± 15.73 years. 17 patients underwent modified radical mastectomy; 11 underwent breast-conserving therapy. The tumor size was T1 in 19 patients, T2 in 8 patients, and T3 in 1 patient. None of the patients had lymph node metastasis. There was no distant metastasis. 18 were stage I, and 10 were stage II. Estrogen receptor, progesterone receptor, HER-2, and P53 were positive in 96, 93, 0, and 28%, respectively. Median follow-up was 42 months (range 1-84 months). 1 patient had local recurrence. The overall survival rate was 100%. Conclusion: Pure mucinous breast carcinoma has a favorable prognosis. Less invasive treatment might be optional. Larger data samples with longer follow-up would be necessary to gain a better understanding of this disease.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pure Mucinous Breast Carcinoma: A Favorable Subtype

Yang

Chun-Hong

et al. 2013

Breast Care

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A novel nomogram and risk classification system for predicting lymph node metastasis of breast mucinous carcinoma: A SEER‐based study

Gai

et al. 2022

Cancer Medicine

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Background Mucinous breast cancer (MBC) is a rare disease, and patients with lymph node metastasis (LNM) have a poor prognosis. We aimed to explore the predictive factors of LNM and to construct a nomogram for predicting the risk of LNM and to identify the suitable axillary surgery for patients with diverse risks. Patients and Methods Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Chi‐square and rank‐sum tests were used to analyze the differences between groups. Survival analysis was performed with Kaplan–Meier curves and log‐rank tests. Independent factor identification and nomogram construction were performed with logistic regression analysis. The nomogram was qualified with a discrimination and calibration plot. Propensity score matching was performed to balance the disparities between groups. Results Patients with metastatic lymph nodes have a worse prognosis. Univariate and multivariate analyses indicated that tumor size, grade, and age were independent risk factors for LNM. The nomogram constructed with these three factors can predict the risk of LNM with high accuracy (AUC: 0.767, 95% CI: 0.697–0.838) and good calibration. Based on the nomogram, a risk classification system satisfactorily stratified the patients into 3 groups with diverse risks of LNM. In the low‐risk group, there were no significant differences between sentinel lymph node biopsy and no axillary surgery. In the middle‐ and high‐risk groups, both SLNB and axillary lymph node dissection were superior to no axillary surgery, with similar survival benefits. Conclusions The nomogram based on tumor size, grade, and age could conveniently and accurately predict the risk of LNM in MBC and assist clinicians in optimizing surgical strategies.

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Nomogram for predicting outcomes in elderly women with mucinous breast cancer: A retrospective study combined with external validation in southwest China

Zhang,

Zhanghuang,

Cai

et al. 2024

Cancer Reports

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ObjectiveMucinous breast cancer (MBC) is a kind of breast cancer (BC), which is rare in clinic, mainly for women, because of the low incidence rate, so there is no unified standard treatment protocol. Elderly patients have a poor prognosis due to their combined comorbidities. This study aims to investigate the effect of surgery and chemoradiotherapy on the prognosis of elderly female MBC patients and construct nomograms for predicting the OS and CSS in elderly female MBC patients.MethodsData for female MBC patients over 65 years are obtained from the Surveillance, Epidemiology and End Results (SEER) database, patients were divided into two groups: the training set and the validation set. External validation data of the prediction model were provided by Kunming Hospital of Traditional Chinese Medicine. We used Cox regression modeling, which was used to identify independent risk factors affecting patient prognosis. After avoiding confounding bias according to the multifactorial Cox regression model, we used these screened statistically significant results to construct column‐line plots. The performance of the model was tested using the consistency index (c‐index), the calibration curve, and the area under the operating characteristic curve of the receiver (AUC). Subsequently, we used decision curve analysis (DCA) to examine the potential clinical value of our nomograms.ResultsA total of 8103 elderly MBC female patients were extracted from the database SEER and were assigned to the training and validation set, randomly. A total of 83 patients from Kunming Hospital of Traditional Chinese Medicine were used in the external verification set. After multifactorial Cox regression analysis, we found that age, race, T‐stage, M‐stage, surgical approach, radiotherapy, and tumor size were independent risk factors for OS in elderly MBC patients. Similarly, independent risk factors of CSS included age, marital status, N stage, M stage, surgical approach, chemotherapy, and tumor size. The C‐index for the OS training, validation, and external verification set were 0.731 (95%CI 0.715–0.747), 0.738 (95%CI 0.724–0.752), and 0.809 (95%CI 0.731–0.8874). The C‐index of the training set, the validation set, and external verification set for CSS were 0.786 (95%CI 0.747–0.825), 0.776 (95%CI 0.737–0.815), and 0.84 (95%CI0.754–0.926), respectively. The AUC, calibration curves and DCA also showed good accuracy.ConclusionsIn this study, we construct a new nomogram to predict the prognosis of elderly patients with MBC. The nomograms have undergone internal and external validation and have been confirmed to have good clinical applicability. At the same time, we found that for elderly female MBC patients, surgery and radiotherapy significantly benefit their survival, but chemotherapy is not conducive to patient survival.

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Pure mucinous carcinoma of the breast

Cited by 89 publications

References 11 publications

Pure Mucinous Breast Carcinoma: A Favorable Subtype

Pure Mucinous Breast Carcinoma: A Favorable Subtype

A novel nomogram and risk classification system for predicting lymph node metastasis of breast mucinous carcinoma: A SEER‐based study

Nomogram for predicting outcomes in elderly women with mucinous breast cancer: A retrospective study combined with external validation in southwest China

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