Pure Polyphenols Applications for Cardiac Health and Disease

Santos, Claudia N.; Gomes, Andréia; Oudot, Carole; Dias-Pedroso, Daniela; Rodriguez-Mateos, Ana; Vieira, Helena L.A.; Brenner, Catherine

doi:10.2174/1381612824666180608102344

Cited by 16 publications

(14 citation statements)

References 176 publications

(258 reference statements)

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“…According to their structural characteristics, they can be roughly divided into flavonoids, phenolic acids, lignans and stilbene. Polyphenols, such as resveratrol, quercetin, curcumin and epigallocatechin gallate, have obvious protective effects against atherosclerosis, hypertension, myocardial infarction, cardiomyopathy caused by anthracyclines, angiogenesis, and HF 157 . Table 2 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 summarizes the polyphenols to treat HF via energy metabolism mechanisms.…”

Section: Potential Drugs For Reducing Hf By Regulating Energy Metabolismmentioning

confidence: 99%

Energy metabolism disorders and potential therapeutic drugs in heart failure

Huang

Zhang

et al. 2021

Acta Pharmaceutica Sinica B

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Heart failure (HF) is a global public health problem with high morbidity and mortality. A large number of studies have shown that HF is caused by severe energy metabolism disorders, which result in an insufficient heart energy supply. This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure, which determine the development of HF and recovery of heart. Current HF therapy acts by reducing heart rate and cardiac preload and afterload, treating the HF symptomatically or delaying development of the disease. Drugs aimed at cardiac energy metabolism have not yet been developed. In this review, we outline the main characteristics of cardiac energy metabolism in healthy hearts, changes in metabolism during HF, and related pathways and targets of energy metabolism. Finally, we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF.

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Section: Potential Drugs For Reducing Hf By Regulating Energy Metabolismmentioning

confidence: 99%

Energy metabolism disorders and potential therapeutic drugs in heart failure

Huang

Zhang

et al. 2021

Acta Pharmaceutica Sinica B

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“…As a result, autophosphorylation of the CaMKII would be reduced in ALDO + PRO80 rats. Certain polyphenols have shown the ability to reduce CaMKII autophosphorylation and oxidation [59,60]. The results suggest that proanthocyanidins could prevent, at least in part, CaMKII overactivation by lowering intracellular calcium overload and ROS production in aldosterone-treated rats.…”

Section: Pro80 Controls Calcium Homeostasis By Regulating Cav12 and Camkii Expressionmentioning

confidence: 88%

Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure

Heras

Galiana-Simal

Ballesteros

et al. 2021

IJMS

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Excess aldosterone promotes pathological remodeling of the heart and imbalance in cardiac ion homeostasis of sodium, potassium and calcium. Novel treatment with proanthocyanidins in aldosterone-treated rats has resulted in downregulation of cardiac SGK1, the main genomic aldosterone-induced intracellular mediator of ion handling. It therefore follows that proanthocyanidins could be modulating cardiac ion homeostasis in aldosterone-treated rats. Male Wistar rats received aldosterone (1 mg kg−1 day−1) +1% NaCl for three weeks. Half of the animals in each group were simultaneously treated with the proanthocyanidins-rich extract (80% w/w) (PRO80, 5 mg kg−1 day−1). PRO80 prevented cardiac hypertrophy and decreased calcium content. Expression of ion channels (ROMK, NHE1, NKA and NCX1) and calcium transient mediators (CAV1.2, pCaMKII and oxCaMKII) were reduced by PRO80 treatment in aldosterone-treated rats. To conclude, our data indicate that PRO80 may offer an alternative treatment to conventional MR-blockade in the prevention of aldosterone-induced cardiac pathology.

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“…Такие полифенолы как ресвератрол, кверцетин, куркумин, галлат эпигаллокатехина, обладают очевидными защитными свой ствами в отношении атеросклероза, артериальной гипертонии, инфаркта миокарда, сердечной недостаточности [108]. Механизм действия полифенолов может быть опосредован через системные эффекты, а также через модуляцию сигнальных путей, таких как окислительно-восстановительная сигнализация, воспаление, аутофагия, гибель клеток в сердце и сосудах, что связывают с изменениями уровня экспрессии и посттрансляционными модификациями белков (Stat1, CaMKII, сиртуины, члены семейства BCL-2, PDE, TRF2, eNOS и SOD) [109]. В настоящее время имеются доказательства, что экстракты, богатые полифенолами, в частности зеленый чай, способны улучшать механические свой ства клеток и внутриклеточную динамику кальция в кардиомиоцитах, увеличивать использование энергии и устранять ингибирующее действие фосфоламбана на Ca2þ-зависимую ATФ-азу саркоплазматического ретикулума (SERCA2) [110].…”

Section: фитотерапевтические подходыunclassified

The Modern Aspects of Nutrition during Chronic Heart Failure

Саликова

Гриневич

Власов

2022

jour

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Nutrition occupies one of the important places in the programs of prevention and non-drug therapy of CHF and associated diseases. At the same time, the validity of dietary recommendations to patients regarding salt intake, dietary habits and the use of individual nutraceuticals is questionable. The purpose of this review is to present up-to-date data of clinical and experimental studies concerning sodium restriction, the use of various diets, nutraceuticals, and means for correcting intestinal dysbiosis in CHF. Materials and methods: the articles are searched in the databases eLibraryRU and Medline by key terms and their combinations: “heart failure”, “diet”, “sodium restriction”, “nutraceuticals”, “nutrition”, “cardiac cachexia”, “nutritional support”, “salt”, “dietary supplement”, “probiotic”, “prebiotic”, “enteral nutrition” in Russian and English. We select articles containing the results of clinical and experimental studies published from 1997 to 2021. The research data indicate that the pathogenesis of anorexia, malnutrition and “metabolic remodeling” of the myocardium in CHF is based on complex mechanisms determined by stagnant phenomena in the liver, impaired permeability of the edematous intestinal wall, dysbiosis and chronic systemic infl ammation. The recommendations on the consumption of sodium from 2 to 2.5 g/day and table salt from 5 to 6 g/day in patients with CHF are justified. Limitation of fluid intake is relevant only for decompensation of CHF. The use of the Mediterranean and antihypertensive (DASH) diets is recognized by most authors as a promising direction for the prevention and treatment of CHF. The enrichment of the diet of patients with CHF with ω-3 polyunsaturated fatty acids, coenzyme Q10, dietary fibers, polyphenols and saponins is justified. The benefits of enteral nutrition and the complex use of nutraceuticals in order to slow the progression of weight loss, reduce the severity of neurohormonal and pro-inflammatory shifts are shown. Promising trends of research are the creation of personalized diets taking into account the peculiarities of the course of CHF, the nutritional status, the composition of the intestinal microbiota and its metabolites.

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Pure Polyphenols Applications for Cardiac Health and Disease

Cited by 16 publications

References 176 publications

Energy metabolism disorders and potential therapeutic drugs in heart failure

Energy metabolism disorders and potential therapeutic drugs in heart failure

Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure

The Modern Aspects of Nutrition during Chronic Heart Failure

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