Pure squamous cell carcinoma of the breast

Lafrenière, René; Moskowitz, Lee B.; Ketcham, Alfred S.

doi:10.1002/jso.2930310208

Cited by 25 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As rates of metastases to the axilla are variable (0–65%), 3,7,12 dissection to Level II axillary clearance is recommended 23 12 …”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of primary SCC of the breast is variably reported, probably reflecting the fact that previous series reported more advanced tumours at presentation and subsequently, a worse prognosis 6 . Later reports are more representative and Lafreniere et al suggested a prognosis equalling infiltrating ductal cancer of up to 9 years, 23 while Cornog et al stated that there was no significant difference between the 5 year survival rate of primary SCC of the breast, and that of all kinds of breast cancer 2 . In a recent series by Cardoso et al , all tumours were diagnosed at a relatively early stage and following standard treatment there were no relapses or cancer related deaths after a mean follow‐up period of 64 months 7 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary squamous cell carcinoma of the breast

Moisidis¹,

Ahmed²,

Carmalt³

et al. 2002

ANZ Journal of Surgery

View full text Add to dashboard Cite

Primary squamous cell carcinoma (SCC) of the breast is a rare condition that has been reported in the literature for over 70 years. We present a series of five cases and discuss management of this condition. METHODSFive (5) primary squamous cell cancers of the breast were identified from the Strathfield Breast Centre database which has prospectively recorded 1658 breast cancers for the period 1989-1999. These records were reviewed, the criteria for inclusion as primary squamous cell cancers were verified and the histopathology was reviewed. CASE REPORTS Case 1A 69-year-old woman presented with a large fungating mass, filling the lateral half of her right breast and a large clinically involved right axillary lymph node. She also presented with mid-thoracic back pain. Computed tomography (CT) scans confirmed the large soft tissue mass in the right axilla but also revealed a right-sided pleural effusion and extensive vertebral body destruction. Bone scans confirmed widespread metastatic carcinoma, and a core biopsy of the breast confirmed squamous cell carcinoma. The patient died of her distant metastatic disease while receiving palliative radiotherapy. Case 2A 71-year-old woman presented with a large cystic mass in her left breast. Aspiration of the cyst resulted in resolution of the mass, and cytological evaluation revealed occasional large degenerate atypical and vacuolated cells of uncertain significance together with macrophages and inflammatory cells. The mass recurred twice over the ensuing 2 months and was subsequently excised. Histopathology showed a cystic mass containing a poorly differentiated squamous carcinoma. The patient proceeded to the completion of mastectomy and in-continuity axillary dissection. Of the 25 axillary nodes examined, none contained metastatic disease. The patient remains alive and disease-free four years postoperatively. Case 3A 50-year-old woman presented with a fungating right breast mass. The mass was fixed to the chest wall but investigations revealed no evidence of metastatic disease. Fine needle cytology and subsequent core biopsy revealed squamous cell carcinoma. She was treated initially with chemotherapy (5-fluorouracil and cisplatinum) followed by radiotherapy. She did not complete therapy due to poor compliance, and when she presented several months later she was noted to have a mass measuring 8 cm in diameter, fixed to the chest wall and clinically involving axillary nodes. Investigations again failed to demonstrate any evidence of spread outside the axilla and after extensive discussions a Halsted radical mastectomy was carried out together with excision of part of the chest wall, removing the third to sixth ribs. A Goretex graft repair of the chest wall and a latissimus dorsi rotation flap with split skin graft were required for reconstruction. Local excision of the tumour was deemed histologically clear from both the chest wall and axilla with only one of the 16 lymph nodes examined containing metastatic SCC. Despite this treatment though, the chest wall tumour recurr...

show abstract

“…As rates of metastases to the axilla are variable (0–65%), 3,7,12 dissection to Level II axillary clearance is recommended 23 12 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the breast

Moisidis¹,

Ahmed²,

Carmalt³

et al. 2002

ANZ Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…Indeed, this case represents the first such tumor in our institution since the initiation of the tumor registry in 1955. Recognition of primary SCC of the breast as a separate entity was challenged for many years by some investigators (1,2]; however, recent reports have confirmed its existence distinct from adenocarcinoma of the breast with squamous cell metaplasia [5,6,10]. Several criteria are required to establish a firm diagnosis of primary SCC of the breast: (1) the infiltrating component of the breast cancer must be entirely squamous; (2) the tumor must be independent from the overlying skin; and (3) another site of SCC in the patient must be excluded […”

Section: Discussionmentioning

confidence: 99%

“…Our case fulfilled all these conditions. Furthermore, the clinical characteristics of the tumor in our patient are similar to those reported by others, including a central cystic necrotic component, overlying skin erythema, ab-sence of nodal metastases, and negative estrogen receptors [5,6]. Interestingly, the breast ultrasound suggested a solid tumor, most likely due to the thick consistency of the fluid that contained necrotic debris.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the breast: Sensitivity to cisplatinum‐based chemotherapy

Dejager

Redlich

Dayer

et al. 1995

Journal of Surgical Oncology

View full text Add to dashboard Cite

Primary squamous cell carcinoma (SCC) of the breast is a rare malignancy whose optimal treatment and prognosis are unknown. A patient with SCC whose tumor responded dramatically to chemotherapy as part of multimodal treatment is presented. A 61-year-old woman had a palpable 5.5-cm tender left breast mass with overlying skin edema and erythema and irregular margins by mammography. Fine needle aspiration revealed malignant squamous cells with keratinization; incisional biopsy confirmed SCC. Extensive evaluation for an extramammary primary site of disease was negative. Neoadjuvant cisplatinum and 5-fluorouracil (5-FU) led to tumor shrinkage and complete resolution of pain and erythema. Modified radical mastectomy with post-operative chest wall radiation were performed. Neither residual invasive carcinoma nor metastatic nodal disease was found, though intraductal carcinoma with marked squamous features was identified. The patient remains disease-free 2.5 years after diagnosis. Cisplatinum-based chemotherapy should be considered in the treatment regimen of this disease.

show abstract

“…Suggested possibilities have included complete metaplasia of the glandular breast tissue (4, 7) and malignancy arising from benign skin lesions (4, 7, 8). Other possibilities have included the development of malignancy from chronic breast abscesses (9), and subcutaneous seeding following trauma to the breast (10,11). Lafreniere et a1 put forward a theory based on the embryological development of the breast (1).…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Breast

Sj¹

1992

Australasian Radiology

View full text Add to dashboard Cite

A patient with pure primary squamous cell carcinoma (SCC) of the breast is reported. The patient was a 72 year old female who presented with a 4 month history of an enlarging left breast mass. Surgery involved a radical mastectomy and this was followed by post-operative radiotherapy and chemotherapy. The patient died of extensive metastatic disease some four months after surgery. The various characteristics of SCC of the breast are briefly discussed. A sub-group of SCC of the breast is identified among reported cases in which the clinical course is characterised by a very rapid growth, extremely aggressive behaviour and early metastasis.

show abstract

Pure squamous cell carcinoma of the breast

Cited by 25 publications

References 14 publications

Primary squamous cell carcinoma of the breast

Primary squamous cell carcinoma of the breast

Primary squamous cell carcinoma of the breast: Sensitivity to cisplatinum‐based chemotherapy

Primary Squamous Cell Carcinoma of the Breast

Contact Info

Product

Resources

About