Pure Yolk-Sac Tumor of the Lung

Başoğlu, Ahmet; Şengül, Ayşen Taslak; Büyükkarabacak, Yasemin Bilgin; Yetim, Tülin Durgun; Yıldız, Levent

doi:10.1177/021849230801600514

Cited by 9 publications

(7 citation statements)

References 5 publications

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“…Extagonadal germ cell tumors are rare, they account for 1% -5% of all germ cell tumors [2] but primary pulmonary location of germ cell tumor is extremely rare, few cases of yolk sac tumors [3][4][5][6] and about 40 cases of choriocarcinomas (PPC) have been reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

Rescigno¹,

Lorenzo²,

Raimondo³

et al. 2012

OJU

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Section: Discussionmentioning

confidence: 99%

Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

Rescigno¹,

Lorenzo²,

Raimondo³

et al. 2012

OJU

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“…We therefore diagnosed primary lung YST with metastatic intracardiac YST. Primary lung YST is very rare and only few cases have ever been reported [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Case report of death from falling: Did heart tumor cause syncope?

et al. 2011

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A healthy man in his 30s was working on the balustrade of stairs on the second floor. He suddenly fell downstairs without saying anything. On emergency hospitalization, chest echogram showed left hemothorax. Cardiac echogram showed a floating mass from the mitral valve in the left ventricle and severe mitral regurgitation. Surgery for hemothorax and pulmonary contusion was immediately undertaken. However, bleeding from pulmonary contusion could not be controlled and he underwent cardiopulmonary arrest. Autopsy showed a white, elastic, pendulous mass in the left atrium and a white mass in the lower lobe of the left lung. Tumor histology showed a reticular pattern, Schiller-Duval bodies, eosinophilic hyaline globules, and positive staining for α-fetoprotein. We diagnosed primary lung yolk sac tumor with metastatic intracardiac yolk sac tumor, a rare and highly malignant germ cell tumor. It usually arises in the ovaries and testes, and intracardiac yolk sac tumor is rare. Intracavitary tumors induce obstruction of inflow into and outflow from the ventricular cavity. The most common clinical presentation is dyspnea and syncope. In the present case, metastatic cardiac yolk sac tumor might have disturbed cardiac outflow and affected hemodynamics, probably causing syncope. Unfortunately, he was in a high place at that time and fell to receive pulmonary contusion that led to death. Autopsy may sometimes reveal latent diseases which might be related to the cause of death. We should perform autopsy thoroughly to diagnose not only the cause of death but also the factors leading to death.

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“…In contrast to rodents, there are some reports indicating that yolk sac carcinoma occurred in the lung in humans with no evidence of a gonadal lesion 14 , 15 , 16 , 17 , 18 . The origin of pulmonary germ cell tumors in humans is not well known, but it is possible that primordial germ cells remain in the region of the mediastinum or lungs at the time of migration along the gonadal ridge during embryogenesis and become the tumor “seed”, eventually developing extragonadal germ cell tumor 17 , 18 , 19 .…”

mentioning

confidence: 95%

“…The origin of pulmonary germ cell tumors in humans is not well known, but it is possible that primordial germ cells remain in the region of the mediastinum or lungs at the time of migration along the gonadal ridge during embryogenesis and become the tumor “seed”, eventually developing extragonadal germ cell tumor 17 , 18 , 19 . The origin of the pulmonary germ cell tumors in these human cases is more similar to that in Pirak’s report 12 than that in the present case.…”

mentioning

confidence: 99%

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

et al. 2016

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Yolk sac carcinoma is an extremely rare tumor in rats and is usually found in the genital system of aged animals. We encountered a yolk sac carcinoma in the pulmonary artery of an 18-week-old female Sprague-Dawley rat. In a repeated dosing toxicity study (once weekly for 4 weeks, intraperitoneal), this rat was unexpectedly found dead on the 55th day after the final administration of the test article. At necropsy, grayish white nodules were found on the lung surface. Histopathologically, tumor emboli were observed in the trunk and branch of the pulmonary artery. Tumor cells with slightly basophilic vacuolated cytoplasm and large vesicular nuclei formed nests or clusters and were embedded in a homogenous eosinophilic and periodic acid-Schiff reaction positive matrix. The tumor cells and matrix were immunoreactive for laminin. The embolic tumor resembled yolk sac carcinoma showing a parietal pattern in rodents. Although the primary site was unknown, the tumor was considered to be a metastatic yolk sac carcinoma.

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Pure Yolk-Sac Tumor of the Lung

Cited by 9 publications

References 5 publications

Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

Case report of death from falling: Did heart tumor cause syncope?

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

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