Purification and characterization of a novel antibacterial peptide from black soldier fly (Hermetia illucens) larvae

Park, Soon-Ik; Kim, Jongwan; Yoe, Sung Moon

doi:10.1016/j.dci.2015.04.018

Cited by 154 publications

(129 citation statements)

References 37 publications

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“…There was no antimicrobial activity against Gram-negative bacteria (E. coli, Enterobacter aerogenes, P. aeruginosa) observed in this study, even at the highest tested concentrations of DLP4 (4.68 μM). The expression of DLP4 in different tissues of the black soldier fly was shown to be the highest in the trachea and fat body (Park et al, 2015).…”

Section: Insects Providing Ampsmentioning

confidence: 99%

“…The AMPs produced by the fat body are secreted into the haemolymph, where their overall concentrations can reach values up to 0.5 mM without exerting toxicity to the host organism. The concentration of AMPs in the insect is far higher than that required to kill most microorganisms in vitro (Bulet and Stöcklin, 2005;Choi et al, 2012;Park et al, 2015).…”

Section: Production and Expression Of Amps In Insectsmentioning

confidence: 99%

“…Constitutive expression of AMPs has also been shown in the reproductive tract of flies and their larvae, where AMPs are expressed in the epithelia of the respiratory (trachea) and gastrointestinal tracts (gut), which may reflect the different lifestyles of larvae and flies. Park et al (2015) showed an increasing AMP (DLP4) expression in the fat body, muscle and trachea of immunized larvae in Hermetia illucens. However, this study also showed high expression of AMPs in the whole body of non-immunized larvae, which may suggest coinsiderable constitutive AMPs production.…”

Section: Production and Expression Of Amps In Insectsmentioning

confidence: 99%

“…Recently, a novel AMP-defensin-like peptide 4 (DLP4) from the black soldier fly has been isolated and described (Park et al, 2015). This protein displays antimicrobial properties against Gram-positive bacteria.…”

Section: Insects Providing Ampsmentioning

confidence: 99%

“…The majority of insect AMPs was isolated from the haemolymph of experimentally infected insects (Dang et al, 2010;Choi et al, 2012;Park et al, 2014Park et al, , 2015Kim et al, 2016), where they are produced in the fat body and in different epithelia. The production of specific AMPs targeted at a specific pathogen may be induced by septic injury by the respective pathogen inducing quick production of antimicrobial peptides (Kim et al, 2016).…”

Section: Production and Expression Of Amps In Insectsmentioning

confidence: 99%

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Insect proteins as a potential source of antimicrobial peptides in livestock production. A review

2017

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Section: Insects Providing Ampsmentioning

confidence: 99%

Section: Production and Expression Of Amps In Insectsmentioning

confidence: 99%

Section: Production and Expression Of Amps In Insectsmentioning

confidence: 99%

Section: Insects Providing Ampsmentioning

confidence: 99%

Section: Production and Expression Of Amps In Insectsmentioning

confidence: 99%

See 3 more Smart Citations

Insect proteins as a potential source of antimicrobial peptides in livestock production. A review

2017

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Black soldier fly (Hermetia illucens L.): A potential small mighty giant in the field of cosmeceuticals

Lai‐Foenander,

Kuppusamy,

Manogoran

et al. 2024

Health Science Reports

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Background and AimsNatural products are widely used in the pharmaceutical and cosmetics industries due to their high‐value bioactive compounds, which make for “greener” and more environmentally friendly ingredients. These natural compounds are also considered a safer alternative to antibiotics, which may result in antibiotic resistance as well as unfavorable side effects. The development of cosmeceuticals, which combine the cosmetic and pharmaceutical fields to create skincare products with therapeutic value, has increased the demand for unique natural resources. The objective of this review is to discuss the biological properties of extracts derived from larvae of the black soldier fly (BSF; Hermetia illucens), the appropriate extraction methods, and the potential of this insect as a novel active ingredient in the formulation of new cosmeceutical products. This review also addresses the biological actions of compounds originating from the BSF, and the possible association between the diets of BSF larvae and their subsequent bioactive composition.MethodsA literature search was conducted using PubMed and Google Scholar to identify and evaluate the various biological properties of the BSF.ResultsOne such natural resource that may be useful in the cosmeceutical field is the BSF, a versatile insect with numerous potential applications due to its nutrient content and scavenging behavior. Previous research has also shown that the BSF has several biological properties, including antimicrobial, antioxidant, anti‐inflammatory, and wound healing effects.ConclusionGiven the range of biological activities and metabolites possessed by the BSF, this insect may have the cosmeceutical potential to treat a number of skin pathologies.

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Insect-Mediated Waste Conversion

Shaboon

Omar

2022

Waste-to-Energy

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Purification and characterization of a novel antibacterial peptide from black soldier fly (Hermetia illucens) larvae

Cited by 154 publications

References 37 publications

Insect proteins as a potential source of antimicrobial peptides in livestock production. A review

Insect proteins as a potential source of antimicrobial peptides in livestock production. A review

Black soldier fly (Hermetia illucens L.): A potential small mighty giant in the field of cosmeceuticals

Insect-Mediated Waste Conversion

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