Purification and characterization of an 18-kd allergen of birch (Betula verrucosa) pollen: Identification as a cyclophilin

Allerjenik Betula (Huş Ağacı) Polenlerinin Türkiye’deki Dağılımları

“…Ancak polenleri özellikle Kuzey ve orta Avrupa'da allerjik rinokonjunktivit ve/veya astım gibi rahatsızlıklara neden olmaktadır (1)(2)(3)(4)(5)(6)(7)(8). Huş ağacı polenlerindeki allerjenlerin belirlenmesine yönelik yapılan çalışmada Betula pendula (=Betula verrucosa) türünde 9-35 kDa arasında allerjenler (Bet v 1-7) saptanmıştır (11,(64)(65)(66)(67)(68)(69)(70). Huş ağacı polen duyarlılığı bulunan hastaların %90'nından fazlasında majör allerjen Bet v 1 allerjenidir (71).…”

Is the quantity of orbicules released by Dactylis glomerata and Cynosurus echinatus (Poaceae) big enough to play an allergenic role?

“…Taking into account that reactivity to minor allergens only occurs in small percentages of pollen-allergic patients (e.g. Cadot et al, 2000;Rossi et al, 2003); the authors concluded that orbicules are not important vectors of allergens in birch allergy. The contrary, however, is found in Cryptomeria japonica and Cupressus spp.…”

Overview of Aspergillus Allergens

“…The presence of cross-reactive structures like enolase and MnSOD, which are also described as latex allergens [16,17], cyclophilin known as a birch pollen allergen [53], thioredoxin described as a prominent food allergen [54], and serine proteases which play an important role in house dust mite allergy [55] indicate that the whole repertoire of allergenic molecules is highly redundant and, thus, limited to a discrete number of structures [56]. In contrast to polysensitisation which is easy to demonstrate by simple determination of the RAST values against different allergen extracts [8], cross-reactivity between fungal extracts is a poorly investigated phenomenon which, however, could contribute to a better understanding of polysensitisation.…”