“…AD45 (Crombie et al, 2015 ; Dawson et al, 2020 ; Gibson et al, 2020 ; Larke‐Mejía et al, 2020 ; van Hylckama Vlieg et al, 2000 ). Isoprene monooxygenase (IsoMO, encoded by isoABCDEF ) catalyses the initial oxidation of isoprene to epoxyisoprene (Crombie et al, 2015 ; Dawson et al, 2020 ; Sims et al, 2022 ; van Hylckama Vlieg et al, 2000 ). An isoprene pathway‐specific glutathione S ‐transferase, IsoI, then conjugates epoxyisoprene with glutathione, a thiol not typically found in Gram‐positive bacteria (Johnson et al, 2009 ), which was also implicated in the mechanistically similar styrene metabolic pathway of Gordonia rubripertincta CWB2 (Heine et al, 2018 ), forming 1‐hydroxy‐2‐glutathionyl‐2‐methyl‐3‐butene (HGMB) (van Hylckama Vlieg et al, 1999 ).…”