Purification, characterization, antioxidant, and antitumor activity of polysaccharides isolated from silkworm cordyceps

Abstract

Cordyceps, a kind of traditional Chinese edible fungus, in general terms, comprises a group of ascomycetous fungi parasitizing insects, some fungi and plants. The practice of using cordyceps as traditional medicine can be traced to several centuries ago, and the production of cordyceps products has currently become a big industry. Health foods and food additives have been developed from natural and cultivated fruit bodies of Cordyceps sinensis, Cordyceps militaris, Isaria cicadae and some other cordyceps and their fermented mycelia (Sung et al. 2007). Among many of the cordyceps, Cordyceps militaris (L.) Link. hosted by many species of lepidopteran pupae is an entomopathogenic fungus in the class Ascomycetes. Hence, for about two decades, many researchers have been focused on the medicinal

Biomass and Cordycepin Production by the Medicinal Mushroom Cordyceps militaris—A Review of Various Aspects and Recent Trends towards the Exploitation of a Valuable Fungus

“…militaris mycelia and ascomata can be generated ex situ with or without the addition of alive and/or dead insect tissues. A wide range of methodologies to produce fruit bodies and mycelia of C. militaris are reported in pertinent literature including: (a) solid-state fermentation [9][10][11][12], (b) submerged static fermentation [11,13], (c) repeated batch or onestep non-static fermentation in liquid media [14][15][16], and (d) cultivation following larval or pupal infection [17,18]. However, commercial exploitation of C. militaris is still in need of improvement in several aspects related to fruit body production, metabolite biosynthesis, and fungal pathogenicity to target insects.…”

The surface morphology of Atractylodes macrocephala polysaccharide and its inhibitory effect on PCV2 replication

“…Congo red is a dye that can verify the helical structure of polysaccharides 19 . The results of the Congo red test were similar to the polysaccharides of Cordyceps sinensis , 20 and there was no obvious red shift, indicating that PAMK did not have a triple helix structure (Fig. 1(B)).…”

Metabolites and Their Bioactivities from the Genus Cordyceps

“…The DPPH radical removal IC 50 values were less than 0.5 mg/mL. In the antitumor activity experiment, SCP II-1 had an IC 50 value of 119.34 ± 1.76 μg/mL against HepG2 cell proliferation [ 74 ]. A polysaccharide (CMP-III) ( 109 ) was isolated from C. militaris ; its average molecular weight was 4.796 × 10 4 kDa; it was composed of glucose, mannose and galactose at an 8.09:1.00:0.25 molar ratio.…”