Purification of an atypical bovine interferon induced in response to heat shock in bovine cultured cells. Characterization in comparison with the classical α, β and γ interferon

Gachet, Yannick; Carpentier, Gilles; Chousterman, S.

doi:10.1016/s0300-9084(97)87624-9

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2000

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“…These data suggest that it is a previously unidentified antiviral molecule. This conclusion is supported by the report of Gachet et al (20), who observed the appearance of an antiviral molecule in bovine leukocytes in response to heat shock. That substance was also antigenically unrelated to either BoIFN-α or -γ.…”

Section: Resultssupporting

confidence: 81%

Induction of Antiviral Response by Electric Pulses

Kovács¹,

Somogyvári

Filipič

et al. 2000

Electro- and Magnetobiology

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Antiviral activity was detected in porcine leukocytes obtained from animals killed in a slaughterhouse. The activity appeared in the supernatant immediately after the addition of Sendai virus, an intended interferon (IFN) inducer. Electroinduction appears to be responsible for the production of antiviral molecules in both porcine and human leukocytes. The macromolecule conferring the antiviral activity is sensitive to heat and pH 2.0 treatment. The preformed or electroinduced antiviral activity originating from porcine leukocytes was not neutralized by either anti-PoIFN-α or anti-PoIFN-γ. The substance involved differs from all known antiviral proteins in that it is not secreted spontaneously into the extracellular space. Its release requires intact and virulent Sendai virus as a trigger signal. Differences in antigenic properties and characteristics indicate that this is a new antiviral substance.

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Section: Resultssupporting

confidence: 81%