Purification of Luteolin and Apigenin From Celery Leaves Using Hybrid Organic–inorganic Monolithic Cartridge

Zhu, Tao; Park, Ha Eun; Row, Kyung Ho

doi:10.1080/10826076.2013.825848

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…This result was confirmed through solid-phase extraction high-performance liquid chromatography (SPE-HPLC) using a hybrid organic-inorganic monolith as the solid-phase adsorbent. 45 4. Combination Therapy of LysGH15 and Apigenin in the Treatment of S. aureus Pneumonia Multiple therapeutic measures are the best option for treating various bacterial infections, including MSSA and MRSA.…”

Section: Results and Discussion 1 Pathogenesis Of Pneumonia Caused By...mentioning

confidence: 99%

Combining Bacteriophage Lysin LYSGH15 and Celery (Apium graveolens L.) Apigenin for Treating Staphylococcus aureus Pneumonia in Children

Habiburrahman¹,

Sutopo²,

Lestari³

2023

Cermin Dunia Kedokteran

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Pneumonia is one of the devastating diseases that affect children under five and can result in high incidence and significant mortality rates. A substantial subset of these cases is caused by Staphylococcus aureus (S. aureus), a Gram-positive bacteria that can cause severe complications and even death. Additionally, antibiotic resistance complicates this problem further. In order to combat this issue, combining flavonoids and bacteriophage products may be a critical solution in decreasing morbidity and mortality rates of pneumonia. Apigenin, extracted from celery (Apium graveolens L.), which has anti-inflammatory and antioxidant effects. Combined with bacteriophage lysin, it can work synergistically against infections and inflammation without being easily resisted by bacteria. This literature review focuses on the use of apigenin and phage lysin, LysGH15, as a treatment for children’s pneumonia, sourced from Google Scholar and PubMed, using several combined keywords such as “new treatment”, “children pneumonia”, “Staphylococcus aureus”, “MRSA”, “new antibacterial”, and “therapy”. Combination therapy shows potential as a new treatment candidate for children’s pneumonia. Pneumonia dikenal sebagai salah satu penyakit paling mematikan pada anak di bawah 5 tahun, dengan insiden 156.000.000 kasus per tahun, dan angka kematian yang signifikan. Salah satu penyebab penting penyakit ini adalah bakteri Gram-positif Staphylococcus aureus (S. aureus), yang sering menyebabkan komplikasi dan kematian. Peningkatan resistensi S. aureus terhadap antibiotik juga memperumit kondisi ini. Kombinasi perawatan yang berasal dari produk flavonoid dan bakteriofag mungkin dapat menjadi kunci untuk menurunkan morbiditas dan mortalitas. Apigenin adalah salah satu jenis flavonoid yang dapat diekstrak dari seledri (Apium graveolans L.). Bersama dengan lisin dari bakteriofag, kedua komponen ini bekerja secara sinergis dalam kasus infeksi dan peradangan, dengan keunggulan berupa tidak mudah mengalami resistensi oleh bakteri. Tinjauan literatur berasal dari Google Scholar dan PubMed menggunakan beberapa kata kunci: “pengobatan baru”, “pneumonia anak”, “Staphylococcus aureus”, “MRSA”, “antibakteri baru”, dan “terapi” berfokus pada penggunaan apigenin dan lisin bakteriofag, LysGH15, sebagai pengobatan untuk pneumonia anak. Terapi kombinasi ini diharapkan berpotensi untuk dikembangkan sebagai pengobatan pneumonia anak.

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Section: Results and Discussion 1 Pathogenesis Of Pneumonia Caused By...mentioning

confidence: 99%

Combining Bacteriophage Lysin LYSGH15 and Celery (Apium graveolens L.) Apigenin for Treating Staphylococcus aureus Pneumonia in Children

Habiburrahman¹,

Sutopo²,

Lestari³

2023

Cermin Dunia Kedokteran

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“…The leaves and stems of celery are also used for seasoning and garnishing dishes. There are many physiological functionalities of celery, such as lowering the cholesterol level, anti-inflammatory, antioxidant, antirheumatic, antihypertension, antidiabetic, antimicrobial, and anticancer activity (Zhu et al 2014;Khairullah et al 2021). Celery contains many bioactive compounds, such as flavonoids, saponins, tannins, apigenin, vitamins A, B, C, and volatile oil, which are used in the pharmaceutical and cosmetic industries (Kooti and Daraei 2017).…”

Section: Introductionmentioning

confidence: 99%

Screening and characterization of endophytic bacteria isolated from celery with the potential to promote plant growth

NURIYANAH,

WIDOWATI,

MASNANG

et al. 2024

Biodiversitas

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Abstract. Nuriyanah, Widowati T, Masnang A, Nurjanah L, Novilasari D, Lekatompessy SJR, Simarmata R. 2023. Screening and characterization of endophytic bacteria isolated from celery with the potential to promote plant growth. Biodiversitas 24: 6897-6904. Endophytic bacteria that inhabit plant tissue contribute to the enhancement of host plant growth by producing secondary metabolites. They can improve plant growth by phytohormone modulation and nutrient uptake. In addition, endophytic bacteria can increase plant health and tolerance by antibiotic and hydrolytic enzyme production. This study aims to screen and characterize endophytic bacteria of celery as plant growth promoter agents. Thirty endophytic bacteria were isolated successfully from part of the celery plant using the spread plate and plant piece method which grew at Nutrient Agar media. Based on the characterization assay, 30 isolates may produce IAA with various concentrations of 0.21-7.18 mg/L. In addition, 3 of 30 isolates had phosphate solubilizing activity, in different indexes ranging from 0.71-1.43. Twenty-one isolates were able to grow in an N-free medium, indicating the capability of isolates to fix nitrogen qualitatively. The hydrolytic enzymes assay resulted in 14 amylolytic, 17 proteolytic, and 12 cellulolytic activities. In addition, nine of 30 isolates show multi-activity in amylase, protease, and cellulase enzyme production. Based on the screening results, there are four potential isolates (SLBg 1.2; SLBg 1.5; SLAg 1.1, and SLAg 1.5) as promising plant-growth promoters and were molecularly identified as members of the Bacillus genus. These isolates can be developed as biofertilizers for supporting the cultivation of celery plants.

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An efficient liposome based method for antioxidants encapsulation

Paini

Daly

Aliakbarian

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Purification of Luteolin and Apigenin From Celery Leaves Using Hybrid Organic–inorganic Monolithic Cartridge

Cited by 5 publications

References 22 publications

Combining Bacteriophage Lysin LYSGH15 and Celery (Apium graveolens L.) Apigenin for Treating Staphylococcus aureus Pneumonia in Children

Combining Bacteriophage Lysin LYSGH15 and Celery (Apium graveolens L.) Apigenin for Treating Staphylococcus aureus Pneumonia in Children

Screening and characterization of endophytic bacteria isolated from celery with the potential to promote plant growth

An efficient liposome based method for antioxidants encapsulation

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