An efficient liposome based method for antioxidants encapsulation

Extraction and purification of formonometin from <i>Trifolium pratense</i> L: Physicochemical properties of its complex with lecithin

“…It has also been used for transdermal drug delivery [16]. In recent years, with its ability to selfassembles at the oil-water interface in various approaches such as micro emulsion [17], hydrogels [14,16], micelles [18], liposomes [19][20][21][22], this commonly used zwitterionic phospholipid surfactant has been used as a carrier for many active ingredients with low solubility to increase their bio-availability.…”

Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice

“…8 Before that, ultracentrifugation method was used to separate TQNLC and free TQ. 28 From the analysis, the retention time was found to be around 2.3 minutes. High encapsulation of TQ (98.84%) was noted.…”

“…The high negative or positive surface charge increases the electrostatic repulsion between particles and decreases the particle aggregation. 28 Zeta potentials above 30 mV or below -30 mV are required for full electrostatic stabilization. However, from the zeta potential analysis, TQNLC showed a negative charge of -11.62 mV.…”

“…Such high EE might be due to the high lipophilicity of TQ, which caused TQ to be attracted to the lipid matrices. 28,30 TQNLC can be considered an ideal nanoformulation based on its particle size, PDI, zeta potential, and DL efficiency. These nanoparticle properties can influence the distribution of nanoparticles within the body.…”

“…31 The particle size and zeta potential are the main factors affecting the nanoparticle cellular uptake, as observed for other nanoparticles such as polymeric and inorganic particles. 28 The small size of the particles makes nanotechnology very useful in medicine, but it may cause adverse effects in humans. Research has shown that smaller particles are more reactive and toxic because the increase in surface area per unit mass is likely to emphasize their intrinsic properties.…”