Extraction and purification of formonometin from &lt;i&gt;Trifolium pratense&lt;/i&gt; L: Physicochemical properties of its complex with lecithin

Brad, Korbanjhon; Zhang, Yan; Gao, Jie

doi:10.4314/tjpr.v16i8.2

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…It was considered that the characteristic endothermic peak of pinocembrin had been masked by the lecithin and there was some interaction between them, such as the combination of hydrogen bonds or van der Waals force [ 22 ]. The results are well supported by previous studies, which were related to the lecithin complexes with phytoconstituents such as formononetin and polydatin [ 25 , 26 ].…”

Section: Resultssupporting

confidence: 90%

“…The structural properties analysis implied that the pinocembrin–lecithin complex displayed the appearance of an amorphous state and no characteristic endothermic peak and, in contrast to the pinocembrin; while the spectra of pinocembrin–lecithin complex contained the characteristic absorption peaks of pinocembrin and lecithin, no novel absorption peak was found, suggesting that no novel covalent bond was produced in the pinocembrin and lecithin compound. These results are in agreement with the reports of other flavone complexes with lecithin [ 25 , 26 ].…”

Section: Discussionsupporting

confidence: 93%

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Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

et al. 2018

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Pinocembrin is a natural flavonoid compound which is capable of antioxidant, antibacterial, anti-inflammatory, and antineoplastic activities. The present study aimed to enhance the solubility and antioxidant activities of pinocembrin by complex formation with lecithin. The physicochemical characteristics of pinocembrin–lecithin complex were analyzed by ultraviolet (UV), fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and solubility assay, and the antioxidant activities of pinocembrin–lecithin complex were evaluated via radical scavenging capacities for 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), hydroxyl, and superoxide-anion. The results indicated that pinocembrin complex with lecithin could significantly improve the solubility of pinocembrin in water and n-octane, the pinocembrin–lecithin complex displayed no characteristic endothermic peak and the appearance of amorphous state, compared to the pinocembrin, and no new covalent bond was produced in the pinocembrin and lecithin compound. It was demonstrated that the antioxidant activities of pinocembrin were obviously enhanced by the complex with lecithin, and the scavenging capacities for hydroxyl radical, DPPH, superoxide-anion radical, and ABTS radical of pinocembrin–lecithin complex were 82.44 ± 2.21%, 40.07 ± 1.32%, 59.15 ± 0.86%, and 24.73 ± 1.04% at 1.0 mg/mL, respectively. It suggested that the pinocembrin–lecithin complex had a great potential application prospect in the healthcare industry and in clinical practice.

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Section: Resultssupporting

confidence: 90%

Section: Discussionsupporting

confidence: 93%

Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

et al. 2018

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“…Formononetin is a bioactive isoflavone found in many herbal medicines, such as Trifolium pretense , Astragalus membranaceus, Glycyrrhiza glabra , and Pueraria lobata . Previous reports show that formononetin has various pharmacological and biological activities, including anti‐oxidant, anti‐atherosclerosis, anti‐osteoporosis, and estrogenic effects . In addition, formononetin has been shown to have a significant inhibition impact on prostate , breast , gastric , cervical , and colorectal cancers .…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of temperature and magnetic dual‐responsive molecularly imprinted polymers for the specific enrichment of formononetin

Zhang

Tan

et al. 2018

J of Separation Science

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Thermo-responsive magnetic molecularly imprinted polymers were prepared by simple surface molecular imprinting polymerization for the selective adsorption and enrichment of formononetin from Trifolium pretense by temperature regulation. Using formononetin as a template, N-isopropylacrylamide as the thermo-responsive functional monomer, and methacrylic acid as an assisting functional monomer, the polymers were synthesized on the surface of the magnetic substrate. The results show that imprinted polymers attained controlled adsorption of formononetin in response to the temperature change, with large adsorption capacity (16.43 mg/g), fast kinetics (60 min) and good selectivity at 35°C compared with that at 25 and 45°C. The selectivity experiment indicated that the materials had excellent recognition ability for formononetin and the selectivity factors were between 1.32 and 2.98 towards genistein and daidzein. The excellent linearity was attained in the range of 5-100 μg/mL, with low detection limits and low quantitation limits of 0.017 and 0.063 μg/mL, respectively. Furthermore, the thermo-responsive magnetic molecularly imprinted polymers were successfully utilized for enriching and purifying formononetin from Trifolium pretense. The analytical results indicate that the imprinted polymers are promising materials for selective identification and enrichment of formononetin in complicated herbal medicines by simple temperature-responsive regulation.

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Formononetin-Loaded Self-Microemulsion Drug Delivery Systems for Improved Solubility and Oral Bioavailability: Fabrication, Characterization, In Vitro and In Vivo Evaluation

Zou,

Xue,

Adu-Frimpong

et al. 2024

AAPS PharmSciTech

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Extraction and purification of formonometin from <i>Trifolium pratense</i> L: Physicochemical properties of its complex with lecithin

Cited by 3 publications

References 25 publications

Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

Preparation and evaluation of temperature and magnetic dual‐responsive molecularly imprinted polymers for the specific enrichment of formononetin

Formononetin-Loaded Self-Microemulsion Drug Delivery Systems for Improved Solubility and Oral Bioavailability: Fabrication, Characterization, In Vitro and In Vivo Evaluation

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