Purification of Organic Chemicals

Armarego, W. L. F.

doi:10.1016/b978-0-323-90967-9.50003-4

Cited by 62 publications

(66 citation statements)

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“…Before use, anhydrous solvents were dried and distilled according to standard methods. [ 32 ] All chemicals used for synthesis were of reagent grade and used without purification unless indicated otherwise. The reactions were executed in a nitrogen atmosphere and were monitored using thin‐layer chromatography on prepared plates (silica gel 60 F254 on aluminum).…”

Section: Methodsmentioning

confidence: 99%

Repurposing of 5‐nitrofuran‐3,5‐disubstituted isoxazoles: A thriving scaffold to antitrypanosomal agents

Carvalho

Neves

Portapilla

et al. 2022

Archiv der Pharmazie

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Chagas disease (CD) is a neglected disease caused by the protozoan Trypanosoma cruzi. The two drugs used in the treatment schedules exhibit adverse effects and severe toxicity. Thus, searching for new antitrypanosomal agents is urgent to provide improved treatments to those affected by this disease. 5-Nitrofuran-isoxazole analogs were synthesized by cycloaddition reactions [3+2] between chloro-oximes and acetylenes in satisfactory yields. We analyzed the structure-activity relationship of the analogs based on Hammett's and Hansch's parameters. The 5-nitrofuran-isoxazole analogs exhibited relevant in vitro antitrypanosomal activity against the amastigote forms of T. cruzi. Analog 7s was the trending hit of the series, showing an IC 50 value of 40 nM and a selectivity index of 132.50. A possible explanation for this result may be the presence of an electrophile near the isoxazole core. Moreover, the most active analogs proved to act as an in vitro substrate of type I nitroreductase rather than the cruzain, enzymes commonly investigated in molecular target studies of CD drug discovery. These findings suggest that 5-nitrofuran-isoxazole analogs are promising in the studies of agents for CD treatment.

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Section: Methodsmentioning

confidence: 99%

Repurposing of 5‐nitrofuran‐3,5‐disubstituted isoxazoles: A thriving scaffold to antitrypanosomal agents

Carvalho

Neves

Portapilla

et al. 2022

Archiv der Pharmazie

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“…Commercially available alkyl halides are frequently not pure enough and so a purification is required. This step involves washing the alkyl halide with various acids and bases and is followed by multiple drying and distillation steps 7 thus generating large amounts of harmful halogenated and aqueous waste.…”

Section: Ionic Liquid Synthesismentioning

confidence: 99%

The dialkylcarbonate route to ionic liquids: purer, safer, greener?

et al. 2023

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“…All commercial chemicals (Aldrich, Alpha, Fischer, SDS) were used as purchased and solvents (Fischer, SDS, Scharlau) purified by the standard procedures prior to use [35] . Reactions were monitored by Thin Layer Chromatography (TLC) (Kieselgel 60 F254 precoated plates, E. Merck, Germany), the spots were detected by exposure to UV light at λ 254 nm, and colourisation with 10% ninhydrin spray, and further heating of the plate.…”

Section: Chemistry Generalmentioning

confidence: 99%