Purified chickpea or lentil proteins impair VLDL metabolism and lipoprotein lipase activity in epididymal fat, but not in muscle, compared to casein, in growing rats

Boualga, Ahmed; Prost, Josiane; Taleb-Senouci, D.; Krouf, Djamil; Kharoubi, Omar; Lamri‐Senhadji, Myriem; Belleville, J.; Bouchenak, Malika

doi:10.1007/s00394-009-0777-4

Cited by 24 publications

(17 citation statements)

References 37 publications

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“…This could be related to the higher essential amino acid content in FLT and FVHT in comparison to GLT and GVHT diets. The food efficiency ratios of faba bean diets observed here (approximately 0·33) were higher than those reported for diets containing 20 % of purified chickpea and lentil proteins (0·21) ( 36 ) . Mixed wheat–legume meals could be an effective way to improve the low nutritional performance of diets with legume protein as the sole protein source and to achieve a similar protein efficiency as a casein control diet (CD).…”

Section: Discussioncontrasting

confidence: 76%

Nutritional evaluation of mixed wheat–faba bean pasta in growing rats: impact of protein source and drying temperature on protein digestibility and retention

et al. 2019

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This study aimed to evaluate the nutritional value of pasta enriched with legume or wheat gluten proteins and dried at varying temperature. A total of four isonitrogenous experimental diets were produced using gluten powder/wheat semolina (6/94, g/g) pasta and faba bean flour/wheat semolina (35/65, g/g) pasta dried at either 55°C (GLT and FLT, respectively) or 90°C (FVHT and GVHT, respectively). Experimental diets were fed to ten 1-month-old Wistar rats (body weight=176 (sem 15) g) for 21 d. Growth and nutritional, metabolic and inflammatory markers were measured and compared with an isonitrogenous casein diet (CD). The enrichment with faba bean increased the lysine, threonine and branched amino acids by 97, 23 and 10 %, respectively. Protein utilisation also increased by 75 % (P<0·01) in FLT in comparison to GLT diet, without any effect on the corrected faecal digestibility (P>0·05). Faba bean pasta diets' corrected protein digestibility and utilisation was only 3·5 and 9 %, respectively, lower than the CD. Growth rate, blood composition and muscle weights were not generally different with faba bean pasta diets compared with CD. Corrected protein digestibility was 3 % lower in GVHT than GLT, which may be associated with greater carboxymethyllysine. This study in growing rats clearly indicates improvement in growth performance of rats fed legume-enriched pasta diet compared with rats fed gluten–wheat pasta diet, regardless of pasta drying temperature. This means faba bean flour can be used to improve the protein quality and quantity of pasta.

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Section: Discussioncontrasting

confidence: 76%

Nutritional evaluation of mixed wheat–faba bean pasta in growing rats: impact of protein source and drying temperature on protein digestibility and retention

et al. 2019

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“…The beneficial effects of legumes on TG levels are derived from the fibers, niacin and certain amino acid compositions of the proteins of legumes [46,49,50,51]. Addition of L -arginine could have caused disturbances in the composition of legume proteins, and the beneficial effects on TG levels mentioned above could have been eliminated.…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>L</i>-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial

Alizadeh

Safaeiyan²,

Ostadrahimi³

et al. 2012

Ann Nutr Metab

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Background/Aims: We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. Methods: This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on an isocaloric diet, participants were randomly assigned to a control diet (HDEL), L-arginine (5 g/day) and HDEL, selenium (200 µg/day) and HDEL or L-arginine, selenium and HDEL for 6 weeks. Cardiovascular risk factors were assessed before intervention and 3 and 6 weeks afterwards. Results: After 6 weeks, L-arginine had significantly reduced waist circumference (WC); selenium had significantly lowered fasting concentrations of serum insulin and the homeostasis model assessment of insulin resistance index; the interaction between L-arginine and selenium significantly reduced the fasting concentration of nitric oxides (NO_x), and HDEL lowered triglycerides (TG) and WC and significantly increased the fasting concentration of NO_x. HDEL reduced high-sensitivity C-reactive protein levels in the first half of the study and returned them to basal levels in the second half. Conclusion: These data indicate the beneficial effects of L-arginine on central obesity, selenium on insulin resistance and HDEL on serum concentrations of NO_x and TG.

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“…Moreover, no toxicity effects by the administration of legumes in any form were reported. However, an increase of hepatic phospholipids was induced by the administration of adzuki beans ( 41 ) , chickpeas and lentils ( 61 ) , in addition to a decrease of LPL activity in epididymal fat reported by the latter study. In addition, in the study of Shahraki et al ( 55 ) , an elevation of AST and ALT was observed in the group that consumed the aqueous extract of T. indica .…”

Section: Discussionmentioning

confidence: 74%

Beneficial effects of legumes on parameters of the metabolic syndrome: a systematic review of trials in animal models

et al. 2016

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Legume consumption plays a pivotal role in the prevention and treatment of the metabolic syndrome (MetS). This systematic review aimed to highlight the beneficial effects of legume interventions for the prevention and/or improvement of parameters related to the MetS and the implicated metabolic pathways so far reported. The methodology involved a search in four electronic databases (Medline, Web of Science, Scopus, Cochrane Library) from January 2007 to December 2014, considering as descriptors 'Metabolic Syndrome' and 'Fabaceae' and adequately adjusting the equation in each one of them. In total, forty-one studies were finally included. The majority of the studies described a regulating effect on glucose and lipid metabolism due to legume administration, whereas effects on blood pressure and renal parameters are not fully described. Regarding the metabolic pathways involved, they include the up-regulation of genes related to β-oxidation and acetyl-CoA degradation and the down-regulation of glycolytic and lipogenesis genes, as well as those associated with the acetyl-CoA synthesis. The ameliorating effects of legume consumption on the alterations associated with the MetS are clearly reported and coincide with changes in the expression of protein and genes involved in lipid and glucose metabolism. More research needs to be conducted including more legume species that are highly consumed as part of a healthy dietary pattern.Key words: Metabolic syndrome: Insulin resistance: Fabaceae: Lipolysis: Metabolic pathwaysThe metabolic syndrome (MetS) represents a clustering of several metabolic disorders among which central obesity and insulin resistance are considered as causative factors (1,2) , affecting one-quarter of the world's adult population (3) . The initial concept of 'Syndrome X' was described by Reaven (4) , whereas the most recent diagnostic criteria, as established by the International Diabetes Federation in 2005 (5) , include obesity (waist circumference ≥ 102 cm in men or ≥88 cm in women), dyslipidaemia (TAG ≥ 150 mg/dl, HDL < 40 mg/dl in men or <50 mg/dl in women), hypertension (≥130 mmHg systolic or ≥85 mmHg diastolic) and alterations of glucose metabolism (>100 mg/dl; includes diabetes) (6) . Although the diagnostic criteria seem to be clear enough, the mechanisms underlying its pathology are not fully understood.Preventing the development of the MetS requires a multidisciplinary approach, whereas the first step on the treatment of this pathology is focused on the amelioration of the related metabolic alterations and includes mostly lifestyle modifications (7) . Nevertheless, in case such modifications prove to be inadequate, the next movement includes the prescription of appropriate pharmacological agents (8) . Among lifestyle strategies, low-fat/low-glycaemic-index diets and regular physical exercise are encountered (7) . For this reason, legumes have gained increasing interest given that their frequent consumption can help in the control of lipid homoeostasis and, consequently, reduce the ris...

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Purified chickpea or lentil proteins impair VLDL metabolism and lipoprotein lipase activity in epididymal fat, but not in muscle, compared to casein, in growing rats

Cited by 24 publications

References 37 publications

Nutritional evaluation of mixed wheat–faba bean pasta in growing rats: impact of protein source and drying temperature on protein digestibility and retention

Nutritional evaluation of mixed wheat–faba bean pasta in growing rats: impact of protein source and drying temperature on protein digestibility and retention

Effect of <i>L</i>-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial

Beneficial effects of legumes on parameters of the metabolic syndrome: a systematic review of trials in animal models

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