1987
DOI: 10.1113/jphysiol.1987.sp016577
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Purinergic inhibition in the small intestinal myenteric plexus of the guinea‐pig.

Abstract: SUMMARY1. The actions of adenosine on electrical behaviour of myenteric neurones were investigated with intracellular recording methods in guinea-pig small intestine.2. The actions of adenosine were: membrane hyperpolarization, decreased input resistance, enhancement of post-spike hyperpolarizing potentials and suppression of excitability. These effects were observed exclusively in AH/type 2 myenteric neurones.3. The presence of adenosine in the micromolar range of concentrations prevented or suppressed excita… Show more

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Cited by 62 publications
(31 citation statements)
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“…This is supported by the finding that exogenous AMP also acts at A 2A receptors to cause slow EPSP-like depolarizations [52]. Exogenous application of adenosine also causes a slow hyperpolarization in some AH neurons [53] through the A 1 receptor and inhibition of adenylyl cyclase [51,54]. Inhibition of adenylyl cyclase reduces the depolarization produced by many neuropeptides that presumably work by increasing cAMP [53,55].…”
Section: Postsynaptic P1 Receptors May Not Mediate Synaptic Potentialsmentioning
confidence: 95%
See 1 more Smart Citation
“…This is supported by the finding that exogenous AMP also acts at A 2A receptors to cause slow EPSP-like depolarizations [52]. Exogenous application of adenosine also causes a slow hyperpolarization in some AH neurons [53] through the A 1 receptor and inhibition of adenylyl cyclase [51,54]. Inhibition of adenylyl cyclase reduces the depolarization produced by many neuropeptides that presumably work by increasing cAMP [53,55].…”
Section: Postsynaptic P1 Receptors May Not Mediate Synaptic Potentialsmentioning
confidence: 95%
“…Exogenous application of adenosine also causes a slow hyperpolarization in some AH neurons [53] through the A 1 receptor and inhibition of adenylyl cyclase [51,54]. Inhibition of adenylyl cyclase reduces the depolarization produced by many neuropeptides that presumably work by increasing cAMP [53,55]. Nonetheless, there is no evidence for a slow IPSP mediated by endogenously released adenosine.…”
Section: Postsynaptic P1 Receptors May Not Mediate Synaptic Potentialsmentioning
confidence: 99%
“…Adenosine inhibited forskolin-induced excitation of myenteric nerves suggesting that adenosine acts to prevent activation of adenylate cyclase by substances mediating slow EPSPs [745]. Adenosine applied to AH (type II) neurons, but not to S (type I) neurons, resulted in membrane hyperpolarisation and decreases in input resistance following opening of K + channels [537]. Adenosine suppressed nicotinic synaptic transmission in myenteric ganglia of the guinea pig gastric antrum and small intestine, by interacting with presynaptic P1 receptors on AH type II neurons [134][135][136][137].…”
Section: Enteric Gangliamentioning
confidence: 99%
“…This action for AH-type neurons was essentially the same as reported for adenosine in AH-type neurons (42). Both adenosine and AMP act to increase K ϩ conductance and thereby clamp the membrane potential of AH neurons to a hyperpolarized level near the K ϩ equilibrium potential (i.e., Ϫ90 mV) and hold the cell soma in a state of low excitability or inexcitability.…”
Section: Discussionmentioning
confidence: 52%
“…Suppression of histamine-activated chloride and calcium conductance (2,47) by adenosine in myenteric neurons is also mediated by A 1 adenosine receptors. Exposure to adenosine increases K ϩ conductance and clamps the membrane potential at hyperpolarized levels in myenteric neurons in guinea pig small intestine (15,42). Stimulation of A 2A adenosine receptors and activation of protein kinase A in the coupled signal transduction cascade are suggested to account for the excitatory actions of adenosine in the guinea pig small intestinal submucosal plexus (3,4).…”
mentioning
confidence: 99%