Purple grumixama anthocyanins (Eugenia brasiliensisLam.) attenuate obesity and insulin resistance in high-fat diet mice

Abstract

The anthocyanins from the purple grumixama phenolic extract is responsible for reducing obesity and insulin resistance.

Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

“…Peroxisomal proliferator-activated receptor (PPAR) is a transcription factor activated by nuclear receptor superfamily ligands; it activates target genes and affects lipid metabolism, glucose homeostasis, cell proliferation, differentiation, apoptosis, and inflammatory responses ( Teixeira et al, 2021 ). Previous studies have confirmed that PPARs are expressed in atherosclerotic plaques, suggesting that PPARs are closely related to atherosclerosis-related mechanisms such as transcriptional regulation of pro-inflammatory genes, e.g., cytokines, chemokines, vascular endothelial cell adhesion factors, and metallostromal proteases ( Corona et al, 2014 ).…”

Lactobacillus acidophilus NX2-6 Improved High-Fat Diet-Induced Glucose Metabolism Disorder Independent of Promotion of Insulin Secretion in Mice

“…1 HFD often gives rise to insulin resistance and consequently disrupts glucose metabolism. 2,3 Insulin resistance represents a reduction in insulin sensitivity and efficacy in insulin-dependent organs, including the adipose tissue, liver, and muscle. 4 The development of insulin resistance is closely associated with chronic lowgrade inflammation.…”

“…Although the development of modern medicine has effectively alleviated several diseases, unhealthy dietary patterns including high-fat diet (HFD), high-sugar diet, and high-calorie diet also contribute to the pathogenesis of metabolic disorder . HFD often gives rise to insulin resistance and consequently disrupts glucose metabolism. , Insulin resistance represents a reduction in insulin sensitivity and efficacy in insulin-dependent organs, including the adipose tissue, liver, and muscle . The development of insulin resistance is closely associated with chronic low-grade inflammation.…”

“…Until now, many studies have discovered that numerous kinds of natural compounds including anthocyanin, polysaccharides, and ginsenoside could improve diet-induced glucose metabolism disorder by suppressing insulin resistance. ,, Next-generation sequencing technology has elucidated the close relationship between intestinal microbiota and metabolic syndrome . Among these gut microbiota, probiotics are one type of health-promoting microorganisms .…”

Efeitos da ingestão dos sucos de laranja das variedades Pera e Moro sobre o proteoma de camundongos submetidos à dieta hiperlipídica e suplementada com leite condensado

“…AÇÃO BIOLÓGICA DA LARANJA Diversos mecanismos estão relacionados as propriedades biológicas dos polifenóis na promoção à saúde, incluindo a modulação de enzimas do sistema antioxidante (Anhê et al 2015;Diaz-Rubio et al, 2015), da via de sinalização inflamatória, regulação de genes do metabolismo lipídico, da lipogênese de novo, da oxidação de ácidos graxos, redução no acúmulo de triglicerídeo hepático (Shimoda et al, 2009 ;Anhê et al, 2017;Song et al, 2016), controle da glicemia e melhora na sensibilidade a insulina e melhora da tolerância a glicose (Aranaz et al, 2019;Teixeira et al, 2021).…”