Purple Sweet Potato Yogurt Affects Lipid Metabolism and Reduces Systemic Inflammation and Oxidative Stress in High Fat Diet Mice

Khairani, Astrid Feinisa; Atik, Nur; Rahman, Putri Halleyana Adrikni; Rohmawaty, Enny; Noviyanti, Cynthia; Santika, Resti; Arimathea, Jose; Shalannandia, Widad Aghnia

doi:10.18585/inabj.v14i3.1921

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Sugata et al reported the inhibitory effects of anthocyanin from purple-fleshed potatoes in lipopolysaccharide-induced inflammation of RAW-264.7 cells by reducing nuclear factor kappa B (NF-Kb), tumor necrosis factor alpha (TNF-α) and IL-6 following a dose-dependent manner [25]. Correlates with recent results, the supplementation of local purple sweet potatoes reduces the level of IL-6 as well as TNF-α in highfat diet mice [26].…”

Section: Resultsmentioning

confidence: 58%

Modifying Effect of Anthocyanin from Purple Sweet Potatoes on Visceral Fat Tissue Inflammation and Liver Oxidative Stress in Psychological Stress-Induced Mice

Kurnianingsih,

Artamevia,

Winarta

et al. 2023

J.Trop.Life.Science

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Psychological stress generates inflammation and oxidative stress in various tissues. Visceral fat as the target site of inflammation is then correlated with stress-induced obesity. Redox imbalance following inflammation also has prominent impacts on hepatic tissue. Therefore, the development of anti-inflammatory and antioxidant properties from plant bioactive compounds is necessary to be investigated. Anthocyanin (ANC) from various plants is previously described as a powerful anti-inflammatory and antioxidant even though its effect in psychological stress remains underexplored. Purple sweet potatoes (PSP) has ANC as its natural pigment. Previous studies revealed the potential effect of ANC from PSP on behavior and an antidepressant candidate. Thus, this study was purposed to determine the effect of ANC from PSP on inflammation and oxidative stress in visceral fat and hepatic tissue respectively. A total of 25 adult male BALB/c mice were assigned into groups of control, stress, stress+ANC 10 mg/kgBW, stress+ANC 20 mg/kgBW and stress+ANC 40 mg/kgBW. Restraint stress was applied 2 hours/day for 14 days. Enzyme-linked immunoassay (ELISA) was conducted to measure level of IL-6 and IL-10 in visceral fat as well as SOD and MDA from hepatic tissue. The results demonstrated that the supplementation of ANC reduces the level of IL-6 cytokine (p=0.005), tends to increase IL-10 (p=0.612), reduces hepatic SOD (p=0.03), and does not significantly affect the level of hepatic MDA (p=0.432). Both ratios of IL-6/IL-10 and SOD/MDA were reduced following ANC administration. Total ANC extracts are suggested to have a potential role of resisting inflammation and oxidative stress in the psychologically stressed model. Further studies are necessary to evaluate the benefits of ANC from PSP in other peripheral organs under psychological stress exposure.

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Section: Resultsmentioning

confidence: 58%

Modifying Effect of Anthocyanin from Purple Sweet Potatoes on Visceral Fat Tissue Inflammation and Liver Oxidative Stress in Psychological Stress-Induced Mice

Kurnianingsih,

Artamevia,

Winarta

et al. 2023

J.Trop.Life.Science

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“…(37) Oxidative stress is caused by the peroxidation of fat cell membranes can observed by examining the level of MDA. (8,38) LN is associated with oxidative stress. ( 12) Expanded peroxidation of cell membrane lipid in LN can cause the arrangement of lipid-derived reactive aldehydes (LDRA) including MDA.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Ameliorates The Expression of Tumor Growth Factor-β and Malondialdehyde in Pristane-induced Lupus Nephritis Mice Model

Soetjipto

Murbani

Harnanik³

2023

Indones Biomed J

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BACKGROUND: Lupus nephritis (LN) is associated with chronic renal failure and a high mortality rate. Tumor growth factor-β (TGF-β) plays a basic part in keeping up immune homeostasis, meanwhile extensive oxidation of the lipid membrane in LN causes the arrangement of malondialdehyde (MDA). Up to date, the mechanism of hyperbaric oxygen (HBO) therapy in LN has not been elucidated well. Hence this study was conducted to assess the impact of HBO therapy on TGF-β and MDA expression in the pristane-induced LN mice model.METHODS: Thirty-two mice aged 8-12 old weeks were isolated into 4 groups: normal saline-injected mice (group 1); pristane-injected mice (group 2); as well as pristane-injected followed by HBO-exposured with 2.4 (group 3) and 1.5 (group 4) atmosphere absolute (ATA) pressure. Pristane were injected intraperitoneal to initiate LN. Two months after pristane injection, the mice were placed within 24 hours in the special cage for metabolic examination to determined that pristane-induced LN mice model was successfully formed and marked by the occurring proteinuria. Oxidative stress was assessed by examining MDA, while systemic inflammation was assessed by examining by TGF-β. MDA and TGF-β serum were measured by enzyme-linked immunosorbent assay (ELISA).RESULTS: A significantly lower (p<0.050) MDA expression was found in group 3 in comparison with group 2. The results also showed that TGF-β level was significantly increased (p<0.050) in group 3 compared to group 2.CONCLUSION: HBO therapy ameliorates inflammation in LN by diminishing MDA and expanding TGF-β levels through activating antioxidants.KEYWORDS: lupus nephritis, hyperbaric oxygen, malondialdehyde, tumor growth factor-β

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Purple Sweet Potato Yogurt Affects Lipid Metabolism and Reduces Systemic Inflammation and Oxidative Stress in High Fat Diet Mice

Cited by 2 publications

References 27 publications

Modifying Effect of Anthocyanin from Purple Sweet Potatoes on Visceral Fat Tissue Inflammation and Liver Oxidative Stress in Psychological Stress-Induced Mice

Modifying Effect of Anthocyanin from Purple Sweet Potatoes on Visceral Fat Tissue Inflammation and Liver Oxidative Stress in Psychological Stress-Induced Mice

Hyperbaric Oxygen Ameliorates The Expression of Tumor Growth Factor-β and Malondialdehyde in Pristane-induced Lupus Nephritis Mice Model

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