Purpura-free small intestinal IgA vasculitis complicated by cytomegalovirus reactivation

Matsumura, Manabu; Komeda, Yoriaki; Watanabe, Tomohiro; Kudo, Masatoshi

doi:10.1136/bcr-2020-235042

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…Latent viral infection reactivation has been considered in the setting of immunosuppression. CMV complicating HSP was observed in both children and adults after high-dose steroid therapy [ 53 , 54 ].…”

Section: Environment Microbial and Virus Infectionsmentioning

confidence: 99%

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Nikolaishvili

Pazhava

Lernia

2023

JCM

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Henoch–Schönlein purpura or IgA vasculitis is the most common type of pediatric vasculitis that may affect adults as well. It is classified as a type of small-vessel vasculitis. It can cause cutaneous and systemic symptoms with a minority of patients developing kidney failure. Little is known about the specific pathophysiology of this disorder, except that it is believed to occur in individuals with abnormally glycosylated IgA1. Serum aberrant IgA1 may form large antigen–antibody complexes which, due to a defective clearance, are able to deposit in the small vessels of the skin, kidney, gut, and joints. A variety of factors, including infectious agents, drugs, and vaccines, have been identified as potential triggers. The majority of cases are preceded by upper respiratory tract infections, and seasonal variations suggest a link with many pathogens. The etiologic agent most frequently associated with IgA vasculitis historically have been group A β-hemolytic streptococcus and common respiratory tract viruses. However, during the current coronavirus pandemic, SARS-CoV-2 infection was identified as a main trigger factor. In addition, IgA vasculitis has been observed following COVID-19 immunization. This review provides insights into the state of the art on the relationship between viral infections, viral vaccines, and Henoch–Schönlein purpura.

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Section: Environment Microbial and Virus Infectionsmentioning

confidence: 99%

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Nikolaishvili

Pazhava

Lernia

2023

JCM

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“…We report a case of a patient with IgA vasculitis complicated by cytomegalovirus infection and tuberculosis. A few cases of IgA nephropathy accompanied by either CMV or reactivation of tuberculosis have been reported so far [5][6][7]. To the best of our knowledge, this is the first reported case of IgA vasculitis complicated by both CMV reactivation and tuberculosis.…”

Section: Introductionmentioning

confidence: 67%

IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis

et al. 2021

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Immunoglobulin A (IgA) vasculitis is the most common systemic vasculitis in the pediatric population. We present the case of a patient with IgA vasculitis with nephritis who developed cytomegalovirus (CMV) infection followed by Mycobacterium tuberculosis infection. In the literature, there are a few cases of IgA nephropathy accompanied by reactivation of CMV or tuberculosis. To the best of our knowledge, this is the first reported case of IgA vasculitis complicated by both CMV reactivation and tuberculosis. It is important to detect infections in patients with IgA vasculitis because they can induce and exacerbate the symptoms of the disease. Effective antimicrobial treatment facilitates the management of proteinuria and slows down the decline of renal function. Immunosuppressive therapy is a risk factor for reactivation of latent infections and makes patients more susceptible to its generalized and complicated course. This can be prevented by actively screening for hidden sites of infection.

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“…Hu et al [ 46 ] also reported that EBV can trigger HSP via cellular and humoral immunity. Several cases of HSP with CMV have suggested that CMV may be a contributing factor [ 47 , 48 , 49 ]. Shin et al [ 50 ] have reported that hepatitis B surface antigens play a role in HSP development.…”

Section: Discussionmentioning

confidence: 99%

An Investigation of the Relationship between Henoch-Schönlein Purpura and Viral Infection in Korea Using the Health Insurance Database

Park,

Jo,

Kim

et al. 2024

JCM

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(1) Background: This study investigated the epidemiology and viral connections of Henoch–Schönlein purpura (HSP) using information from the Korea Disease Control and Prevention Agency and the Health Insurance Review and Assessment database. (2) Method: Between 2016 and 2019, a total of 25,443 patients with HSP were identified, with 51.3% of patients under the age of 20 years and the highest incidence in March. (3) Results: The autoregressive integrated moving average model and Granger causality test were used to analyze the association between the virus positivity detection rate and HSP incidence. (4) Conclusions: The incidence of HSP was associated with rotavirus, bocavirus, parainfluenza virus, and respiratory syncytial virus in individuals under 20 years of age, whereas adenovirus, respiratory syncytial virus, and norovirus were associated with individuals above that age.

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Purpura-free small intestinal IgA vasculitis complicated by cytomegalovirus reactivation

Cited by 11 publications

References 19 publications

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Viral Infections May Be Associated with Henoch–Schönlein Purpura

IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis

An Investigation of the Relationship between Henoch-Schönlein Purpura and Viral Infection in Korea Using the Health Insurance Database

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