Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis

Prayogo, Rizky Lendl; Rahmayunita, Githa; Agustin, Triana; Sirait, Sondang P.; Arisanty, Riesye

doi:10.1111/pde.14054

Cited by 4 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significance of nail involvement in patient prognosis is controversial. Although it is associated with multi-system involvement and poor prognosis, some studies have reported that patients with nail involvement show favorable prognoses, as in this case 3 4 . Therefore, whether nail change constitutes an independent indicator for prognosis remains to be elucidated.…”

mentioning

confidence: 66%

Symmetrical Longitudinal Erythronychia on Both Thumbs: A Case Report

Xiao,

Tu,

Wang

2023

Ann Dermatol

View full text Add to dashboard Cite

mentioning

confidence: 66%

Symmetrical Longitudinal Erythronychia on Both Thumbs: A Case Report

Xiao,

Tu,

Wang

2023

Ann Dermatol

View full text Add to dashboard Cite

“…8 Among all the organs, LCH occurring in vulvar and nail was extremely rare for children, its dermoscopic and RCM features had been less investigated, meanwhile, nail LCH (NLCH) and vulvar LCH (VLCH) indicated the herald symptom of underlying multisystem disease. 11,12 We retrieved the papers in the fields of LCH, dermoscopy, and RCM from the NCBI, Web of Science, and Google of database, the dermatoscopic and RCM features of VLCH have less been investigated. We found that the clinical characteristics of children VLCH and/or N LCH (presented onycholysis and purpuric striae 13 ) were different from those of adults and other anatomic locations and were also prone misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Among all the organs, LCH occurring in vulvar and nail was extremely rare for children, its dermoscopic and RCM features had been less investigated, meanwhile, nail LCH (NLCH) and vulvar LCH (VLCH) indicated the herald symptom of underlying multisystem disease 11,12 . We retrieved the papers in the fields of LCH, dermoscopy, and RCM from the NCBI, Web of Science, and Google of database, the dermatoscopic and RCM features of VLCH have less been investigated.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopy and reflectance confocal microscopy finding of different anatomic sites of Langerhans cell histiocytosis

Zhang,

Wang,

Wang

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

BackgroundRecognizing Langerhans cell histiocytosis (LCH) might be a challenge due to its rarity. Reflectance confocal microscopy (RCM) and dermoscopy were emergent promising non‐invasive technique as auxiliary tools in diagnosis of different skin conditions. However, the RCM and dermoscopic features of LCH had been less investigated. To reveal the common RCM and dermoscopic features of LCH.Materials and methodsForty cases of LCH were retrospectively analyzed according to age, locations, clinical, RCM, and dermoscopic features from September 2016 to December 2022. To reveal the differences and common in clinical, RCM, and dermoscopic features that occur in different anatomic location.ResultsIn the study, sites of predilection include the trunk 31/40 (77.5%), extremity 21/40 (52.5%), face 14/40 (35%), scalp 11/40 (27.5%), vulvar 4/40 (10%), and nail 2/40 (5%). All LCHs had the common RCM features. There were significant differences in clinical and dermoscopic features for age and lesion anatomic site. The common dermoscopic features for scalp, face, trunk, and extremity were the erythematous scaly rash, purplish‐red globules or patches, scar‐like streaks with ectatic vessels. While the features for nail LCH were purpuric striae, onycholysis and purulent scaly rash, and the erosive erythematous plaque and purulent scaly rash for vulvar LCH. The common RCM features of all LCH showed a focal highly reflective dense image in the surface keratin layer, epidermis architectural disarray, obscuration of dermo‐epidermal junction, numerous polygonal, large, medium reflective, short dendrites cells in the epidermis, and dermis. All LCH involving the vulvar and nail did not manifest skin lesions.ConclusionRCM and dermoscopy showed promising value for diagnosis and differentiation of LCH.

show abstract

“…et al (2020) describe a 9-month-old boy with longitudinal stripes, onychodystrophy and paronychia on the nail plates of the hands and feet. Nail damage was the initial manifestation of multisystem Langerhans cell histiocytosis [14]. G. Moreno-Coutiño et al (2016) in their study consider the occurrence of onychodystrophy in elderly patients as a possible marker of peripheral artery disease, being an important factor in early diagnosis [15].…”

Section: Introductionmentioning

confidence: 99%

Development of a bioaction complex for the onychodystrophy treatment

et al. 2020

View full text Add to dashboard Cite

This article is devoted to the problem of onychodystrophy treatment. The purpose of the study was to develop a bioactive complex for the external treatment of onychodystrophies. We conducted a prospective cohort study to determine the emotional status and life quality of patients with onychodystrophies. The optimal composition and technology for producing a complex for the onychodystrophy treatment was determined in vitro. We made a literature review using the PubMed, eLibrary, Scopus, Web of Science search engines. The structure of onychodystrophies in patients of the study group was determined, clinical forms such as leukonychia, paronychia, onycholysis were diagnosed the most frequently. A significant decrease in life quality was found in 86.8% of patients. A new method of onychodystrophies treatment using the innovative medical complex, which includes an emulsion for external use and camouflage nail polish is proposed. The developed bioactive complex for patients with onychodystrophy will contribute to the rapid regeneration of the changed nail plate due to improved microcirculation and trophic innervation. More viscous and thick consistency physiological colour nail polish which does not require polymerization, will create a visual effect of a healthy nail plate, which will improve the life quality of patients with onychodystrophy.

show abstract

Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis

Cited by 4 publications

References 11 publications

Symmetrical Longitudinal Erythronychia on Both Thumbs: A Case Report

Symmetrical Longitudinal Erythronychia on Both Thumbs: A Case Report

Dermoscopy and reflectance confocal microscopy finding of different anatomic sites of Langerhans cell histiocytosis

Development of a bioaction complex for the onychodystrophy treatment

Contact Info

Product

Resources

About