Putative Roles of Plant-Derived Tannins in Neurodegenerative and Neuropsychiatry Disorders: An Updated Review

Abstract

Neurodegenerative and neuropsychiatric diseases are characterized by the structural and functional abnormalities of neurons in certain regions of the brain. These abnormalities, which can result in progressive neuronal degeneration and functional disability, are incurable to date. Although comprehensive efforts have been made to figure out effective therapies against these diseases, partial success has been achieved and complete functional recovery is still not a reality. At present, plants and plant-derived compounds are getting more attention because of a plethora of pharmacological properties, and they are proving to be a better and safer target as therapeutic interventions. This review aims to highlight the roles of tannins, ‘the polyphenol phytochemicals’, in tackling neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases as well as neuropsychiatric disorders like depression. Among the multifarious pharmacological properties of tannins, anti-oxidative, anti-inflammatory, and anti-cholinesterase activities are emphasized more in terms of neuroprotection. The current review also throws light on mechanistic pathways by which various classes of tannins execute neuroprotective effects. Despite their beneficial properties, some harmful effects of tannins have also been elaborated.

Moringa oleifera Lam.ameliorates the muscles function recovery following an induced insult to the Sciatic nerve in a mouse model

“…In order to cope with this need, scientists are exploring effective and affordable remedies to accelerate functional reclamation and endorse axonal regeneration Hussain, Zhang, et al, 2018). Meanwhile, plants and plant-derived compounds are getting more consideration because of their health-promoting properties (Hussain et al, 2019;Hussain, Zhang, et al, 2018) Moringa has been widely utilized as folk medicine owing to its rich phytochemistry with special reference to various phytoconstituents such as alkaloids, saponins, tannins, steroids, phenolic acids, glucosinolates, flavonoids, and terpenes. However, the presence of phenolic acids, glucosinolates, and flavonoids are responsible for its anticancer, neuroprotective, and antioxidant potential through various mechanistic routes.…”

Hydrolyzable vs. Condensed Wood Tannins for Bio-based Antioxidant Coatings: Superior Properties of Quebracho Tannins

“…Tannins occupy a prominent role among natural phenolic compounds due to their remarkable antioxidant, antimicrobial, and anticancer activities [ 1 , 2 , 3 ]. Apart from these biologically relevant properties, these compounds have always been known for their ability to strongly interact with proteins, which has prompted their use in the leather tanning industry [ 4 , 5 ].…”

Foeniculum vulgare (Fennel) promotes functional recovery and ameliorates oxidative stress following a lesion to the sciatic nerve in mouse model

“…The major emphasis of modern research is to identify and characterize the unexplored bioactive molecules from plant source to cure the incurable diseases. There are several classes of phytochemicals which have been reported to offer neuroprotective potential in brain diseases (Hussain et al, ; Hussain, Rasul, et al, ; Hussain, Zhang, et al, ; Liu, ). Fascinatingly, the therapeutic capability of such material has been disclosed against the neuronal symptoms by bestowing anti‐inflammatory and antioxidant properties (Hussain, Zhang, et al, ; Uriarte & Calvo, ).…”