Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19

Kumar, Raman; Rathi, Himani; Haq, Afrozul; Wimalawansa, Sunil J.; Sharma, Alpana

doi:10.1016/j.virusres.2020.198235

Cited by 133 publications

(128 citation statements)

References 117 publications

(134 reference statements)

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“…There is evidence that vitamin D is correlated with diminished risk and severity of COVID-19 infection through different mechanisms (decreasing the production of inflammatory cytokine, decreasing the survival and replication of viruses, preserving endothelial integrity, and augmenting angiotensin-converting enzyme 2 concentrations) [ 46 ]. The prophylactic vitamin D administration in the COVID-19 management was underscored [ 47 ]. Various studies were revised and the recommended daily dose by consensus during the COVID-19 pandemic, 2000 IU for teenagers and adults, is 20 times lower than the amount which must be taken for many months to cause toxicity [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Turcu-Știolică

Bogdan

Subtirelu

et al. 2021

JCM

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Community pharmacists are essential front-line health workers, involved in relieving the COVID-19 burden. Their health-related quality of life status needs to be assessed, as lower levels could affect their functioning. In order to evaluate the current status of community pharmacists’ quality of life from Romania and Bulgaria during the COVID-19 pandemic, and to identify factors associated with their decision on being vaccinated to prevent COVID-19, an online survey involving 395 community pharmacists was conducted from July 15th, 2020 to August 15th, 2020. The 15D instrument was used for quality-of-life assessment. The pharmacists’ recommendations for vitamin C and D intake during the COVID-19 pandemic were also analyzed in order to promote future training programs for community pharmacists. Descriptive statistics, comparative analyses between pharmacists from Romania and Bulgaria, and multiple correlation analyses were performed on the collected data. Significant differences were observed for the level of quality of life between the two groups of pharmacists according to their age; smaller values, directly correlated with their age (total 15D score and age: Spearman r = 0.168, p = 0.022), were obtained for Bulgarian pharmacists regarding sleeping, usual activities, mental function, discomfort and symptoms, depression, distress. The perception of being vaccinated did not differ between Romanian and Bulgarian pharmacists, as almost 50% agreed to vaccination (p = 0.7542). Their willingness to vaccinate was correlated with vitamin D usage (p = 0.0134), rather than with vitamin C (p = 0.4157). No other significant associations were found between willingness to get vaccinated to prevent COVID-19 and other characteristics (age, gender, income, quality-of-life markers). Evidence-based interventions are required to enhance the health-related quality of life of community pharmacists involved in the first line of the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Turcu-Știolică

Bogdan

Subtirelu

et al. 2021

JCM

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“…SARS-CoV-2 binding to ACE2 drives an increase in ACE activity and angiotensin II production, resulting in vasoconstriction, pulmonary edema and increased severity of COVID-19. Calcitriol may play a protective role here via induction of ACE2 expression and inhibition of renin activity (103)(104)(105). Interactions between RAS and vitamin D in advanced COVID-19 are further discussed [see below and shown in Figure 1…”

Section: Evidence For a Protective Role For Vitamin D In Covid-19mentioning

confidence: 99%

New Roles for Vitamin D Superagonists: From COVID to Cancer

2021

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Vitamin D is a potent steroid hormone that induces widespread changes in gene expression and controls key biological pathways. Here we review pathophysiology of vitamin D with particular reference to COVID-19 and pancreatic cancer. Utility as a therapeutic agent is limited by hypercalcemic effects and attempts to circumvent this problem have used vitamin D superagonists, with increased efficacy and reduced calcemic effect. A further caveat is that vitamin D mediates multiple diverse effects. Some of these (anti-fibrosis) are likely beneficial in patients with COVID-19 and pancreatic cancer, whereas others (reduced immunity), may be beneficial through attenuation of the cytokine storm in patients with advanced COVID-19, but detrimental in pancreatic cancer. Vitamin D superagonists represent an untapped resource for development of effective therapeutic agents. However, to be successful this approach will require agonists with high cell-tissue specificity.

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“…[3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , ...…”

Section: Uncited Referencesunclassified

Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease

Frohman

Villemarette-Pittman

Rodríguez

et al. 2021

Journal of the Neurological Sciences

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The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of our human physiology's most important and vulnerable life-preserving body tissue; our brocho-alveolar gas exchange apparatus. Notwithstanding the fear and the fury of this microbe's potential to raise existential questions across the entire spectrum of human endeavor, the application of an early treatment intervention initiative, may represent a crucial tool in our defensive strategy. This strategy is driven by evidence-based medical practice principles, those not likely to become antiquated, given the molecular diversity and mutational evolution of this very clever “world traveler” .

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Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19

Cited by 133 publications

References 117 publications

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

Influence of COVID-19 on Health-Related Quality of Life and the Perception of Being Vaccinated to Prevent COVID-19: An Approach for Community Pharmacists from Romania and Bulgaria

New Roles for Vitamin D Superagonists: From COVID to Cancer

Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease

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