Puumala Hantavirus Excretion Kinetics in Bank Voles (<i>Myodes glareolus</i>)

Hardestam, Jonas; Karlsson, Malin; Falk, Kerstin I.; Olsson, Gert E.; Klingström, Jonas; Lundkvist, Åke

doi:10.3201/eid1408.080221

Cited by 110 publications

(115 citation statements)

References 20 publications

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“…The hantavirus infections in these rodents were probably produced through inhalation of viral particles or licking. Hardestam et al 45 observed that hantavirus transmission through saliva among rodents is more common than through inhalation of excreta containing viral particles.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Figueiredo

Borges

Campos

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction: Hantavirus pulmonary and cardiovascular syndrome (HPCS) is an emerging serious disease in the Americas. Hantaviruses (Bunyaviridae) are the causative agents of this syndrome and are mainly transmitted through inhalation of aerosols containing the excreta of wild rodents. and Akodon sp (1.5%). Nucleotide sequences obtained through RT-PCR from one HPCS patient and one Calomys tener rodent were compared with hantavirus sequences from GenBank, which showed that both were homologous with ARAV. Conclusions: This work corroborates previous studies showing that ARAV is the hantavirus causing HPCS in the Ribeirão Preto region. It also shows that rodents infected with hantavirus represent a constant risk of transmission of this virus to man.

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Section: Discussionmentioning

confidence: 99%

Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Figueiredo

Borges

Campos

et al. 2010

Rev. Soc. Bras. Med. Trop.

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“…Infection with this virus is considered to be chronic (Meyer and Schmaljohn, 2000). Voles experience a transient period of viremia, beginning a few days after infection and peaking 2-4 weeks post-infection (Hardestam et al, 2008), although viral RNA has been detecting 84 days post-infection in some experimentally infected bank voles. Periodic episodes of viral recrudescence may occur during the lifetime of the vole, because of changes in the virus and/or host immune response (Hardestam et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Voles experience a transient period of viremia, beginning a few days after infection and peaking 2-4 weeks post-infection (Hardestam et al, 2008), although viral RNA has been detecting 84 days post-infection in some experimentally infected bank voles. Periodic episodes of viral recrudescence may occur during the lifetime of the vole, because of changes in the virus and/or host immune response (Hardestam et al, 2008). Besides, anti-hantavirus immunoglobulin G are usually detectable 2 weeks after infection and seems to remain detectable for the lifetime of the rodents (see references in Easterbrook and Klein, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Field surveys and laboratory experiments have indicated that the probability of infection with PUUV differs between individual bank voles, which also differ in their response to PUUV infection (Olsson et al, 2002;Hardestam et al, 2008;Deter et al, 2008b;Guivier et al, 2010a). Polymorphism and variability in the expression of immune genes may determine the ability of the vole to control hantavirus replication (Plyusnin et al, 1997;Makela et al, 2002;Klein et al, 2004;Terajima et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Landscape features and helminth co-infection shape bank vole immunoheterogeneity, with consequences for Puumala virus epidemiology

et al. 2013

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Heterogeneity in environmental conditions helps to maintain genetic and phenotypic diversity in ecosystems. As such, it may explain why the capacity of animals to mount immune responses is highly variable. The quality of habitat patches, in terms of resources, parasitism, predation and habitat fragmentation may, for example, trigger trade-offs ultimately affecting the investment of individuals in various immunological pathways. We described spatial immunoheterogeneity in bank vole populations with respect to landscape features and co-infection. We focused on the consequences of this heterogeneity for the risk of Puumala hantavirus (PUUV) infection. We assessed the expression of the Tnf-a and Mx2 genes and demonstrated a negative correlation between PUUV load and the expression of these immune genes in bank voles. Habitat heterogeneity was partly associated with differences in the expression of these genes. Levels of Mx2 were lower in large forests than in fragmented forests, possibly due to differences in parasite communities. We previously highlighted the positive association between infection with Heligmosomum mixtum and infection with PUUV. We found that Tnf-a was more strongly expressed in voles infected with PUUV than in uninfected voles or in voles co-infected with the nematode H. mixtum and PUUV. H. mixtum may limit the capacity of the vole to develop proinflammatory responses. This effect may increase the risk of PUUV infection and replication in host cells. Overall, our results suggest that close interactions between landscape features, co-infection and immune gene expression may shape PUUV epidemiology.

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“…The main host of PUUV is the bank vole (Myodes glareolus), and the virus is predominantly transmitted horizontally to humans via exposure to contaminated vole excreta [13,39,42]. Human infection is characterized by sudden onset of fever, head and backache, vomiting, and abdominal pain often accompanied by visual disturbances [24].…”

Section: Introductionmentioning

confidence: 99%

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Fevola

Forbes

Mäkelä

et al. 2016

Journal of Clinical Virology

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a b s t r a c tBackground: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients.

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Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus)

Abstract: One-sentence summary for table of contents: Virus may be transmitted by saliva, urine, and feces, and saliva may play a role in transmission to humans.

Cited by 110 publications

References 20 publications

Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Landscape features and helminth co-infection shape bank vole immunoheterogeneity, with consequences for Puumala virus epidemiology

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

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