Political parties in much of sub-Saharan Africa are often statewide , but the societies are characterized by salient ethno-regional cleavages. Statewide parties, therefore, frequently encounter strategic challenges around ethno-regional mobilization and demands for special rights or self-rule. What shapes these parties' strategic choices? We analyze whether party strategies are characterized by accommodation, opposition, or dismissal, and argue that their strategies are shaped by the degree to which contestation around territorial politics are centralized. We examine this argument by comparing how regionally dominant statewide parties have responded to ethno-regional mobilization in the Niger Delta in federal Nigeria and the Coast region in more centralized Kenya over the last decade, and find that centralized contestation over ethno-regional issues forces parties to engage with ethno-regional demands while decentralized contestation allows parties to dismiss them.