PWE-110 Acceptance and Adjustment in a District General Cohort of Inflammatory Bowel Disease Patients: Findings and Implications

Swart, Nicholas; Wellsted, David; Lithgo, K; Price, T; Johnson, Matt

doi:10.1136/gutjnl-2013-304907.398

Cited by 4 publications

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“…The study also showed that AYAs with IBD had lower quality of life scores than AYAs with other chronic illnesses, and although these did not reach statistical significance, they were lower than scores previously recorded in similar cohorts 26 . For IBD-specific quality of life, the mean score obtained in this study (44.1) was lower than the mean scores reported in an adult older cohort (52.6 for males; 51.4 for females) and in mixed cohorts (patients aged 16 years and above) (mean SIBDQ scores = 48.0, 48.4) 27,28 . These findings further highlight the significance and magnitude of the impairment in quality of life amongst AYAs living with IBD.…”

Section: Discussioncontrasting

confidence: 81%

“…17 For IBD-specific quality of life, the mean score obtained in this study (44.1) was lower than the mean scores reported in an adult older cohort (52.6 for males; 51.4 for females) and in mixed cohorts (patients aged 16 years and above) (mean SIBDQ scores = 48.0, 48.4). 26,27 These findings further highlight the significance and magnitude of the impairment in quality of life among AYA living with IBD. In the present study, young people with IBD also had a lower internal locus of control compared to peers with other disorders, indicating that they are less likely to believe that they have control over their condition.…”

Section: Discussionmentioning

confidence: 86%

“…On the Kessler-10, participants' scores were also categorised into: non-clinical (total score <20, where maximum possible score = 50), mild (20)(21)(22)(23)(24), moderate (25)(26)(27)(28)(29), and severe (total score ≥30). Similarly, on the WHO-5 measure, young people who obtained a score of <13 were considered to have poor wellbeing (maximum possible score = 25) 22 .…”

Section: Measurement Toolsmentioning

confidence: 99%

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Psychosocial burden of inflammatory bowel disease in adolescents and young adults

Halloran

McDermott

Ewais

et al. 2021

Internal Medicine Journal

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 86%

Section: Measurement Toolsmentioning

confidence: 99%

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Psychosocial burden of inflammatory bowel disease in adolescents and young adults

Halloran

McDermott

Ewais

et al. 2021

Internal Medicine Journal

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“…We are presently recruiting additional cases and controls to increase study power for additional analysis. 10.1136/gutjnl-2014-307263.343 Introduction A recent study indicated that 30% of IBD patients suffer from psychological distress, and that poor acceptance and adjustment is a predictor of distress (Swart et al 2013). Psychological distress encompasses the symptoms of depression, anxiety, emotional difficulty and poor adjustment, but is not the same as mental illnesses such as Major Depressive Disorder or Generalised Anxiety Disorder.…”

Section: Referencesmentioning

confidence: 99%

PWE-082 The Impact Of Nod2 Variants On Gut Microbiota In Crohn’s Disease And Healthy Controls

Kennedy

Walker

Berry

et al. 2014

Gut

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Methods We studied 8 patients, identified from our anticoagulation database, who had been previously established on warfarin, and then commenced azathioprine or mercaptopurine for inflammatory bowel disease (2), systemic lupus erythematosus (1), nephritic syndrome (1), Wegener's granulomatosis (1), polyarteritis nodosa (1), dermatomyositis (1) and renal transplant (1). The effect of thiopurine on international normalised ratio (INR), and warfarin dose prior to and following commencement of thiopurine was recorded. Results In 6/8 patients, following introduction of azathioprine or mercaptopurine, the warfarin dose had to be significantly increased (100% , Median [range]) in order to maintain a therapeutic INR. Any subsequent reductions in thiopurine dose were mirrored by a rise in INR and lower requirement for warfarin.In 2 IBD patients, each with a high warfarin requirement, thiopurine metabolites were measured. In both patients MeMP: TGN ratio was >11. Thiopurine dose was reduced to 25% and allopurinol 100 mg added. INR was carefully monitored. In both cases INR increased within a week (to 6.9 and 11.2) and warfarin doses were subsequently reduced by ½ and 2/3 respectively to regain therapeutic INR. Conclusion It is important for clinicians to be aware of the potential inhibitory action of thiopurines on warfarin's anticoagulant effect. Close INR monitoring is essential when initiating thiopurines and especially when reducing their dose and/or adding allopurinol. Failure to recognise the latter could result in bleeding due to over-anticoagulation. The high MeMP:TGN ratio in 2 of our patients also raises the possibility that thiopurine metabolites may play a role in the interaction between thiopurines and warfarin. Introduction Faecal calprotectin is recommended by NICE 1 for distinguishing between irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) in patients with lower gastrointestinal (GI) symptoms in primary care. If cancer is suspected in these patients and 'red-flag' symptoms such as anaemia or bleeding, they should be referred to Gastroenterology in accordance with the NICE suspected cancer guideline. 2 We use calprotectin in secondary care and will be extending the service to primary care providers. However, a number of GPs have been requesting faecal calprotectin on an ad-hoc basis for 1 year, giving us valuable insight into how the test performs in primary care. Methods An audit was carried out of primary care calprotectin data in a 1 year period (Dec 12-Dec 13). This data was compared to an audit of 1 month of secondary care data (Jun 13). Clinical details, such as endoscopy and histology results were extracted from electronic patient records. Results In total 198 requests for calprotectin came from primary care in 1 year and 40 were unsuitable for analysis (wrong sample type or delayed arrival in lab). Of the remaining 158 calprotectin requests, 76% were considered appropriate, having clinical details including symptoms described by NICE. Worryingly, 17% of requests had inappropriat...

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People Living with Inflammatory Bowel Disease Want Multidisciplinary Healthcare: A Qualitative Content Analysis

Feeney

Chur‐Hansen

Mikocka‐Walus

2021

J Clin Psychol Med Settings

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PWE-110 Acceptance and Adjustment in a District General Cohort of Inflammatory Bowel Disease Patients: Findings and Implications

Cited by 4 publications

References 0 publications

Psychosocial burden of inflammatory bowel disease in adolescents and young adults

Psychosocial burden of inflammatory bowel disease in adolescents and young adults

PWE-082 The Impact Of Nod2 Variants On Gut Microbiota In Crohn’s Disease And Healthy Controls

People Living with Inflammatory Bowel Disease Want Multidisciplinary Healthcare: A Qualitative Content Analysis

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