Dynamic binary instrumentation (DBI) techniques allow for monitoring and possibly altering the execution of a running program up to the instruction level granularity. The ease of use and flexibility of DBI primitives has made them popular in a large body of research in different domains, including software security. Lately, the suitability of DBI for security has been questioned in light of transparency concerns from artifacts that popular frameworks introduce in the execution: while they do not perturb benign programs, a dedicated adversary may detect their presence and defeat the analysis. The contributions we provide are twofold. We first present the abstraction and inner workings of DBI frameworks, how DBI assisted prominent security research works, and alternative solutions. We then dive into the DBI evasion and escape problems, discussing attack surfaces, transparency concerns, and possible mitigations. We make available to the community a library of detection patterns and stopgap measures that could be of interest to DBI users. CCS CONCEPTS • Security and privacy → Systems security; Intrusion/anomaly detection and malware mitigation; Software reverse engineering; Software security engineering.