PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery After Flexor Tendon Repair Surgery: Randomized Controlled Trial

Wiig, Monica; Dahlin, Lars B.; Fridén, Jan; Hagberg, Lars; Larsen, Søren E.; Mahlapuu, Margit

doi:10.1016/j.jhsa.2014.06.094

Cited by 5 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four high-quality RCTs were found (Tab. X) [143][144][145][146] . HA products with higher molecular weight and longer half-life favor a greater permanence of HA into intrasynovial peritendinous space compared to native HA and low molecular weight formulations, ensuring greater clinical efficacy.…”

Section: Hyaluronic Acid In Tendon and Bursamentioning

confidence: 99%

I.S.Mu.L.T. Hyaluronic acid injections in musculoskeletal disorders guidelines

Frizziero

Vittadini

Oliva

et al. 2019

Muscle Ligaments and Tendons J

View full text Add to dashboard Cite

Section: Hyaluronic Acid In Tendon and Bursamentioning

confidence: 99%

I.S.Mu.L.T. Hyaluronic acid injections in musculoskeletal disorders guidelines

Frizziero

Vittadini

Oliva

et al. 2019

Muscle Ligaments and Tendons J

View full text Add to dashboard Cite

“…Closest to clinical translation include pharmacological agents that inhibit adhesions. Lactoferrin-derived peptide PXL01, formulated in sodium hyaluronate, significantly improves mobility without any negative effect on healing strength demonstrated in animal models (Hakansson et al, 2012) and early clinical trials (Wiig et al, 2014). Hyaluronic acid in a variety of forms, including carbodiimide-derivatized hyaluronic acid combined with Lubricin (cd-HA-Lubricin), can modulate tendon surface quality, which eliminates graft adhesions and improves digit function in a canine model, whereas clinical efficacy has also been shown in randomized controlled trials.…”

Section: Basic Science Strategies To Solving the Problemmentioning

confidence: 99%

Basic science approaches to common hand surgery problems

Wong

Murphy

et al. 2021

J Hand Surg Eur Vol

View full text Add to dashboard Cite

The field of hand surgery is constantly evolving to meet challenges of populations with increasing age and higher demands for active living. While our surgical care has improved over the last decades, it seems that future major improvement in outcomes of clinical treatment will come through advances in biologics and the translation of major discoveries in basic science. This article aims to provide an update on where basic science solutions may answer some of the most critical issues in hand surgery, with a focus on augmentation of tissue repair.

show abstract

“…8 A few AMPs have been carrying clinical trials, human cathelicidin member LL-37 to promote the healing of venous leg ulcers 9 and PXL01, derived from human lactoferricin, to prevent postsurgical adhesion formation (NCT01022242) were conducted. 10,11 We first reported that the cathelicidin family of AMPs exists in reptile species of Naja atra, Bungarus fasciatus, and Ophiophagus hannah snake species. 12 We focused on cathelicidin from king cobra (OH30) and revealed that this peptide has strong antibacterial activity against various bacteria in the presence of 1% NaCl.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl chitosan nanoparticles loaded with bioactive peptide OH-CATH30 benefit nonscar wound healing

Sun¹,

Zhan²,

Zhang³

et al. 2018

IJN

View full text Add to dashboard Cite

BackgroundNonscar wound healing is a desirable treatment for cutaneous wounds worldwide. Peptide OH-CATH30 (OH30) from king cobra can selectively regulate the innate immunity and create an anti-inflammatory micro-environment which might benefit nonscar wound healing.PurposeTo overcome the enzymatic digestion and control release of OH30, OH30 encapsulated in carboxymethyl chitosan nanoparticles (CMCS-OH30 NP) were prepared and their effects on wound healing were evaluated.MethodsCMCS-OH30 NP were prepared by mild ionic gelation method and properties of the prepared CMCS-OH30 NP were determined by dynamic light scattering. Encapsulation efficiency, stability and release profile of OH30 from prepared CMCS-OH30 NP were determined by HPLC. Cytotoxicity, cell migration and cellular uptake of CMCS-OH30 NP were determined by conventional methods. The effects of prepared CMCS-OH30 NP on the wound healing was investigated by full-thickness excision animal models.ResultsThe release of encapsulated OH30 from prepared CMCS-OH30 NP was maintained for at least 24 h in a controlled manner. CMCSOH30 NP enhanced the cell migration but had no effects on the metabolism and proliferation of keratinocytes. In the full-thickness excision animal models, the CMCS-OH30 NP treatment significantly accelerated the wound healing compared with CMCS or OH30 administration alone. Histopathological examination suggested that CMCS-OH30 NP promoted wound healing by enhancing the granulation tissue formation through the re-epithelialized and neovascularized composition. CMCS-OH30 NP induced a steady anti-inflammatory cytokine IL10 expression but downregulated the expressions of several pro-inflammatory cytokines.ConclusionThe prepared biodegradable drug delivery system accelerates the healing and shows better prognosis because of the combined effects of OH30 released from the nanoparticles.

show abstract

PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery After Flexor Tendon Repair Surgery: Randomized Controlled Trial

Cited by 5 publications

References 30 publications

I.S.Mu.L.T. Hyaluronic acid injections in musculoskeletal disorders guidelines

I.S.Mu.L.T. Hyaluronic acid injections in musculoskeletal disorders guidelines

Basic science approaches to common hand surgery problems

Carboxymethyl chitosan nanoparticles loaded with bioactive peptide OH-CATH30 benefit nonscar wound healing

Contact Info

Product

Resources

About