Pyelonephritis in pregnancy: Once-a-day ceftriaxone versus multiple doses of cefazolin

Sánchez-Ramos, Luis; McAlpine, Kenneth J.; Adair, Charles; Kaunitz, Andrew M.; Delke, Isaac; Briones, Donna

doi:10.1016/0002-9378(95)90100-0

Cited by 38 publications

(16 citation statements)

References 5 publications

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“…Three studies provided data on spontaneous preterm birth before 37 weeks' gestation and/or neonatal intensive care admissions. 402,405,406 Data for at least one of these outcomes were available on the following comparisons: Only one study was found for each comparison, with one study 406 contributing to three of the comparisons. There were no significant differences between antibiotic regimens in incidence of spontaneous preterm birth before 37 weeks (Figures 113-117), or in admission to neonatal intensive care units (Figures 118-120), or in other perinatal and maternal outcomes ( Table 6).…”

Section: Antibiotics For Symptomatic Urinary Tract Infectionsmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Section: Antibiotics For Symptomatic Urinary Tract Infectionsmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

View full text Add to dashboard Cite

show abstract

“…Second-or third-generation cephalosporins may also be considered for single-agent therapy [1]. With these treatment regimens, more than 95% of women will respond within 72 hours [43,44]. Resistant organisms must be considered in women who do not respond appropriately to treatment, and antimicrobials should be changed according to culture results.…”

Section: Treatmentmentioning

confidence: 99%

Asymptomatic Bacteriuria and Symptomatic Urinary Tract Infections During Pregnancy

Macejko

Schaeffer

2007

Urologic Clinics of North America

115

102

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“…The rise of extended spectrum β-lactamase (ESBL)-producing bacteria is compounding the problem, because antimicrobials such as the cephalosporins, which have a good safety profile in pregnant women, are rendered ineffective. Only four randomized control trials in pregnant women including 90,20 178,21 179,22 and 101,23 or 548 women in total, have assessed antimicrobial efficacy. These studies concluded that in non-bacteremic patients, oral cephalexin (500 mg every 6 hours) did not differ in efficacy and safety from intravenous (IV) cephalothin (1 g every 6 hours) treatment20; one time daily IV ceftriaxone was as effective as multiple daily doses of cefazolin 22.…”

Section: Introductionmentioning

confidence: 99%

“…Only four randomized control trials in pregnant women including 90,20 178,21 179,22 and 101,23 or 548 women in total, have assessed antimicrobial efficacy. These studies concluded that in non-bacteremic patients, oral cephalexin (500 mg every 6 hours) did not differ in efficacy and safety from intravenous (IV) cephalothin (1 g every 6 hours) treatment20; one time daily IV ceftriaxone was as effective as multiple daily doses of cefazolin 22. No difference in clinical response was observed with IV ampicillin and gentamicin, IV cefazolin, or intramuscular ceftriaxone,23 whereas cefuroxime (750 mg every 8 hours IV) was more efficacious and better tolerated than cephradine (1 g every 6 hours IV) 21.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and Treatment Difficulties of Pyelonephritis in Pregnancy in Resource-Limited Settings

McGready¹,

Wuthiekanun²,

Ashley³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Limited microbiology services impede adequate diagnosis and treatment of common infections such as pyelonephritis in resource-limited settings. Febrile pregnant women attending antenatal clinics at Shoklo Malaria Research Unit were offered urine dipstick, sediment microscopy, urine culture, and a 5-mL blood culture. The incidence of pyelonephritis was 11/1,000 deliveries (N = 53 in 4,819 pregnancies) between January 7, 2004 and May 17, 2006. Pyelonephritis accounted for 20.2% (41/203) of fever cases in pregnancy. Escherichia coli was the most commonly isolated pathogen: 87.5% (28/32) of organisms cultured. Susceptibility of E. coli to ampicillin (14%), cotrimoxazole (21%), and amoxicillin-clavulanic acid (48%) was very low. E. coli was susceptible to ceftriaxone and ciprofloxacin. The rate of extended spectrum β-lactamase (4.2%; 95% confidence interval = 0.7–19.5) was low. The rate and causes of pyelonephritis in pregnant refugee and migrant women were comparable with those described in developed countries. Diagnostic innovation in microbiology that permits affordable access is a high priority for resource-poor settings.

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Pyelonephritis in pregnancy: Once-a-day ceftriaxone versus multiple doses of cefazolin

Cited by 38 publications

References 5 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Asymptomatic Bacteriuria and Symptomatic Urinary Tract Infections During Pregnancy

Diagnostic and Treatment Difficulties of Pyelonephritis in Pregnancy in Resource-Limited Settings

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