Pyoderma gangrenosum associated with ulcerative colitis: response to infliximab

Román, Antonio; Bermejo, Fernando; Aldanondo, Isabel; Carrera, E.; Boixeda, D; Zato, Ernesto Muñoz

doi:10.4321/s1130-01082004000600008

Cited by 20 publications

(12 citation statements)

References 21 publications

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“…[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The vast majority of these reports describe patients with PG who were treated with infliximab for underlying CrohnÕs disease. The largest series of PG patients treated with infliximab is a multicenter retrospective study by Regueiro et al 20 In this study, 13 patients with long-standing inflammatory bowel disease (12 with CrohnÕs disease, 1 with ulcerative colitis) and refractory PG were treated with infliximab.…”

Section: Infliximabmentioning

confidence: 99%

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Off-Label Dermatologic Uses of Anti-TNF-a Therapies

Alexis

Strober

2005

J Cutan Med Surg

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Section: Infliximabmentioning

confidence: 99%

“…[22][23][24][25][26][27][28][29] Most recently, the use of infliximab in the treatment of chronic lymphocytic leukemia-associated PG has been reported. 36 Importantly, this patient did not have inflammatory bowel disease.…”

Section: Infliximabmentioning

confidence: 99%

Off-Label Dermatologic Uses of Anti-TNF-a Therapies

Alexis

Strober

2005

J Cutan Med Surg

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“…In the most severe and corticorefractary cases, cyclosporine A, tacrolimus, azathioprine, or micophenolate mofetil, ciclophosphamide, clorambucil, intravenous gammaglobulin, thalidomide, etanercept, Infliximab, adalimumab, clofazimine, dapsone, metronidazole and nicotine have been used (14)(15)(16)(17)(18). Some studies have shown that treatment of resistant cases can be done with other immunosuppressants.…”

Section: Discussionmentioning

confidence: 99%

Atypical pyoderma gangrenosum in inflammatory bowel disease: A severe diagnostic challenge

Muñoz

Ugidos

Montiel

et al. 2009

Rev. esp. enferm. dig.

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Pyoderma gangrenosum (PG) is a rare inflammatory and ulcerative disease of the skin of unknown etiology. Diagnosis of PG is based on clinical and histological data and requires the exclusion of other ulcerative diseases of the skin. There is an atypical form of PG that appears generally associated with hematological malignancies and rarely has been described in patients with inflammatory bowel disease (IBD). We describe the case of a patient diagnosed with IBD in whom symptomatology was mainly extraintestinal as atypical PG. Case reportA 39-year-old man was referred to our hospital complaining of diarrhea consisting in passage of six to eight liquid stools containing mucus and small amounts of blood each day. One year before, he had been diagnosed of IBD, likely ulcerative colitis, and was treated with corticosteroids and topical 5-aminosalicilates. At the time of hospitalization, in addition to diarrhea, he showed fever (38 ºC), anemia, leukocytosis and elevated reactive C protein serum levels (20.4 ng/mL). Physical examination revealed the presence of a perianal fistula. The colonoscopy demonstrated hyperemia, edema, friability, and granularity, as well as pinpoint ulceration of the colonic mucosa. These changes were diffuse and extended from the rectum throughout the left colon. Histologicaly, it displayed changes consistent with IBD. The patient was treated with high

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“…The relation between between PG and the extension, length and severity of IBD is controversial. PG is a relatively rare extraintestinal presentation of ulcerative proctocolitis, and its incidence ranges from 2 and 12% 17,18,19 , affecting both genders and all age groups. It is also associated with Chron's disease, however, the prevalence of such association is lower than the one observed for ulcerative proctocolitis 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum as a initial manifestation of ulcerative proctocolitis

Fonseca¹,

Motta²,

Rampazzo³

et al. 2011

J. Coloproctol. (Rio J.)

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301FONSECA CB, MOTTA GL, RAMPAZZO A, JUNIOR JCC, FAGUNDES RB. Pyoderma gangrenosum as a initial manifestation of ulcerative proctocolitis. Rev bras Coloproct, 2011;31(3): 301-305.AbstRACt: pyoderma gangrenosum is a rare inflammatory skin condition characterized by progressive and recurrent skin ulceration of destructive course. It is usually associated with rheumatoid arthritis, paraproteinemia, myeloproliferative diseases and inflammatory bowel diseases, especially non-specific ulcerative proctocolitis. In these situations, skin lesions are described as concurrent with the intestinal condition. However, reports on pyoderma gangrenosum preceding intestinal findings are less frequent. The authors describe a case of a woman with febrile condition associated with skin lesions diagnosed by biopsy as pyoderma gangrenosum. Two weeks later, she developed diarrhea, arthralgia and sepsis, being diagnosed as ulcerative proctocolitis. After the administration of the treatment for ulcerative proctocolitis, she showed improvements in sepsis care, remission of diarrhea and regression of skin lesions. This case highlights the importance of considering pyoderma gangrenosum as a manifestation associated with inflammatory bowel disease, regardless of its timing in relation to intestinal symptoms.

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Pyoderma gangrenosum associated with ulcerative colitis: response to infliximab

Cited by 20 publications

References 21 publications

Off-Label Dermatologic Uses of Anti-TNF-a Therapies

Off-Label Dermatologic Uses of Anti-TNF-a Therapies

Atypical pyoderma gangrenosum in inflammatory bowel disease: A severe diagnostic challenge

Pyoderma gangrenosum as a initial manifestation of ulcerative proctocolitis

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