Pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with x-linked agammaglobulinaemia

Dua, Janet; Elliot, E.; Bright, Philip; Grigoriadou, Sofia; Bull, R.H.; Millar, M.; Wijesuriya, N.; Longhurst, Hilary

doi:10.1111/j.1365-2230.2011.04293.x

Cited by 18 publications

(15 citation statements)

References 9 publications

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“…Helicobacter cinaedi often causes enteritis and bacteraemia, and sometimes causes cellulitis and arthritis . In rare cases it causes meningitis, infective endocarditis, infected aortic aneurysm, myopericarditis and pyoderma gangrenosum‐like ulcer . Most patients are immunocompromised, having HIV infection, haematological diseases, renal failure or a current history of anticancer chemotherapy.…”

Section: Clinical Features and Characteristic Skin Manifestations Of mentioning

confidence: 99%

“…An English‐language PubMed search revealed only two dermatological papers describing H. cinaedi infection. One is a case report that describes pyoderma gangrenosum‐like ulcer caused by H. cinaedi in a patient with primary immunodeficiency; the other is our previously published retrospective case report of 47 patients with H. cinaedi bacteraemia in one hospital, which revealed that no fewer than 34% of the cases were accompanied by superficial mild cellulitis as the initial manifestation of the disease . Evaluation of the skin manifestations would play an important role in diagnosing H. cinaedi bacteraemia, as the existence of H. cinaedi is often overlooked owing to its slow growth rate in the culture bottle.…”

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confidence: 99%

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Cutaneous manifestations ofHelicobacter cinaedi: a review

Shimizu

2016

Br J Dermatol

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Helicobacter cinaedi is an emerging Gram-negative spiral bacillus that was first reported in 1984. It has been implicated as a cause of gastroenteritis and bacteraemia in immunocompromised individuals. Helicobacter cinaedi-associated bacteraemia is sometimes accompanied by skin lesions; however, the cutaneous manifestations of this pathogen are not widely known. To our knowledge, a comprehensive review with detailed analysis of skin lesions associated with H. cinaedi has not been conducted. This article summarizes the clinical appearance of H. cinaedi cellulitis and its management. In addition, we conducted a retrospective review of 73 patients with H. cinaedi bacteraemia at a single institution, to further clarify the characteristic cutaneous features. It was found that 30% (22/73) of the cases of H. cinaedi bacteraemia had sudden-onset erythema accompanied by high fever. The most common cutaneous symptom of H. cinaedi bacteraemia was found to be mild cellulitis, appearing as multiple painful infiltrated erythemas on the extremities. As H. cinaedi is not always detectable in routine blood culture techniques, evaluation of these characteristic cutaneous manifestations seems important in diagnosis. Helicobacter cinaedi infection should be added to the diagnostic list of unspecified fever with painful infiltrated erythemas.

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Section: Clinical Features and Characteristic Skin Manifestations Of mentioning

confidence: 99%

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confidence: 99%

Cutaneous manifestations ofHelicobacter cinaedi: a review

Shimizu

2016

Br J Dermatol

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“…Clinically PG starts with a sterile pustule, nodule or bulla that rapidly progresses and turns into painful ulceration with raised, undermined borders and necrotic eschar. PG-like ulcer caused by Helicobacter cinaedi and Campylobacter species have been reported in a patient with X-linked agammaglobulinaemia2. There was no clear difference about the morphologic characteristics of the mucocutaneous lesions between those and this case.…”

Section: Discussionmentioning

confidence: 45%

“…With an incidence of 1 in 100,000 to 1 in 200,000 of the population2, these individuals carry a mutation in the B-cell tyrosine kinase (BTK) gene encoding for a tyrosine kinase critical for B-cell maturation3. In myeloid and dendritic cells, BTK has been found to be a component of Toll-like receptor (TLR) signaling, important for recognition of foreign pathogens4.…”

Section: Introductionmentioning

confidence: 99%

Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia

2017

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X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder caused by germline mutations of B-cell tyrosine kinase (BTK) gene. It is characterized by decreased serum immunoglobulins levels and circulating mature B cells. This defect in humoral immunity leads to increased susceptibility to infection. Pyoderma gangrenosum (PG) is an uncommon, ulcerating, neutrophilic dermatosis. Here we report PG in an 8-year-old patient with XLA. The patient received intravenous immunoglobulin treatment in conjunction with prednisone and topical application of 0.03% tacrolimus ointment and the ulcer was almost completely healed in the 2 weeks of follow-up. The coexistence has been rarely reported. XLA may be a possible cofactor in the pathogenesis of PG.

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“…in 67% of the samples; the majority were infected with H. pylori (57%) and only 6% and 4% coinfected with "Helicobacter heilmannii" and Helicobacter felis, respectively [10]. Finally, a case study reported a pyoderma gangrenosum-like ulcer caused by H. cinaedi in a patient with X-linked agammaglobulinemia [11].…”

Section: Other Diseasesmentioning

confidence: 99%

Helicobacter spp. Other than H. pylori

Rossi

Hänninen

2012

Helicobacter

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Significant advances have been made over the last 12 months in the understanding of the biology of non-H. pylori Helicobacter species (NHPH). Several studies have investigated the association between NHPH and human disease, including Crohn's disease, lithiasis, liver disease, coronary disease, gastritis, and pyoderma gangrenosum-like ulcers. Novel Helicobacter taxa were identified in new vertebrate hosts, and new methodologies in the fields of identification of Helicobacter spp. and evaluation of antibiotic resistance were described. The genome of the first human-derived gastric NHPH strain (Helicobacter bizzozeronii CIII-1) was sequenced, and several studies elucidated functions of different genes in NHPH. A number of important investigations regarding pathogenesis and immunopathobiology of NHPH infections have been published including the description of a new urease in Helicobacter mustelae. Finally, the effects of the gut microbiota and probiotics on NHPH infections were investigated.

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Pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with x-linked agammaglobulinaemia

Cited by 18 publications

References 9 publications

Cutaneous manifestations ofHelicobacter cinaedi: a review

Cutaneous manifestations ofHelicobacter cinaedi: a review

Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia

Helicobacter spp. Other than H. pylori

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