2020
DOI: 10.1001/jamadermatol.2019.3515
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Pyodermatitis Pyostomatitis Vegetans

Abstract: A man in his 20s presented with a 1-month history of extensive and painful vegetating plaques on the lips and buccal and nasal mucosa. His medical history was notable for Crohn disease treated for the previous 6 years with high doses of sulfasalazine (3000 mg/d). A physical examination revealed multiple friable pustules coalescing into vegetativeanderosiveplaqueswithyellowexudateandhemorrhagiccrust on the upper and lower labial mucosa. Similar exophytic plaques were noted to involve the nasal mucosa, resulting… Show more

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Cited by 6 publications
(15 citation statements)
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“…They are used as systemic, intralesional, and topical treatments depending on disease severity. All the cases reviewed that used corticosteroids achieved clearance, however relapse was common when tapering [1][2][3][4][6][7][8][9][10][11][12][13]. Other systemic treatments for PPV include dapsone, azithromycin,…”
Section: Discussionmentioning
confidence: 99%
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“…They are used as systemic, intralesional, and topical treatments depending on disease severity. All the cases reviewed that used corticosteroids achieved clearance, however relapse was common when tapering [1][2][3][4][6][7][8][9][10][11][12][13]. Other systemic treatments for PPV include dapsone, azithromycin,…”
Section: Discussionmentioning
confidence: 99%
“…Often the clinical courses of PPV and IBD are parallel [1], and successful management of the underlying IBD typically results in resolution of PPV [2]. However, there have also been cases in which PPV develops and persists despite well controlled IBD [1,3,4].…”
Section: Avens Publishing Groupmentioning
confidence: 99%
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“…3 Pyodermatitispyostomatitis vegetans (PD-PSV) is a rare clinical entity manifesting as pustular mucocutaneous vegetative lesions mostly in the oral mucosa, and less commonly affecting the axillary and genital areas. 4 PD-PSV is strongly associated with IBD, most commonly ulcerative colitis and occasionally with CD. 5 Reports on PD-PSV in the pediatric population are scarce.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, this condition is often associated with an underlying inflammatory bowel disease (IBD) namely Crohn's disease (CD) and ulcerative colitis (UC). 1,2 There is considerable evidence that the paediatric cases of IBD are on the rise with the peak incidence of IBD occurring in patients between the ages of 15 and 30 years. [1][2][3][4][5] In patients below 20 years of age, CD constitutes nearly 20% of the cases, whereas 12% of them develop UC.…”
Section: Introductionmentioning
confidence: 99%