Pyrazolylphenanthroimidazole heterocycles: synthesis, biological and molecular docking studies

Abstract

Synthesis of a series of novel pyrazolylphenanthroimidazoles 6a-6j has been accomplished utilizing multi-step synthetic protocol and characterized through physical and spectral techniques. Among them, the molecules possessing para-bromo (6d), para-methyl...

Tetrazolopyrimidine-tethered phenothiazine molecular hybrids: synthesis, biological and molecular docking studies

“…The methodology is none other than the hybridization of more than one unrelated structural motif of biological significance possessing molecules in order to yield a novel bio-significant chemical entity with superior activity. [49][50][51][52][53][54] Prompted by the aforementioned strategy and our contemporary discoveries on the progress of small heterocyclic chemical entities as biorelevant agents, [55][56][57][58] we synthesized a series of phenothiazinebased heterocyclic molecules tethered with tetrazole and pyrimidine units (Fig. 4) and evaluated their radical scavenging, cytotoxicity and molecular docking properties.…”

Transition metal-free and temperature dependent one-pot access to phenanthrene-fused heterocycles via a 1,3-dipolar cycloaddition pathway

“…7 Besides, pyrazolylphenanthrolimidiazoles have been known to exhibit anti-inflammatory activities. 8 Also, phenanthrene-fused pyrazoles are fluorescent and redox-active organic materials (Fig. 1).…”