Pyrethroids used indoors – Immune status of humans exposed to pyrethroids following a pest control operation – a one year follow-up study

Hadnagy, W.; Leng, G.; Sugiri, Dorothee; Ranft, Ulrich; Idel, Helga

doi:10.1078/1438-4639-00201

Cited by 29 publications

(11 citation statements)

References 20 publications

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“…Blood concentrations of pentachlorophenol also correlated positively with plasma concentrations of neopterin (Daniel et al 2001a). In contrast, serum neopterin gave no indication of significant changes after pesticide control operation using pyrethroids (Hadnagy et al 2003) and plasma neopterin showed no associations with blood concentrations of polychlorinated biphenyls, hexachlorocyclohexane isomers and hexachlorobenzene (Daniel et al 2001b). …”

Section: Discussionmentioning

confidence: 88%

Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

et al. 2014

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Neopterin and biopterin are often used as markers of cell mediated immunity. The aim of this study was to evaluate the effect of prochloraz on neopterin and biopterin concentrations in blood plasma of common carp as possible indicators for monitoring perturbations of the immune system caused by xenobiotics like pesticides. Prochloraz is a widely used imidazole fungicide in horticulture and agriculture. A total of 60 juvenile common carp were divided into four groups of 15 fish and exposed to prochloraz at concentrations of 0, 50, 150 and 380 µg·l -1 , respectively. The total length of exposure was 28 days. Neopterin and biopterin concentrations were determined by reverse phase high performance liquid chromatography with fluorescence detection. Our results indicated that concentrations of neopterin (25 ± 7.6 nmol·l -1 ) and biopterin (190 ± 29 nmol·l -1 ) in plasma of untreated common carp were comparable with those in mammals. Neopterin concentrations significantly (P < 0.01) increased after exposure to prochloraz in comparison to non-exposed fish, while biopterin concentrations were not influenced by exposure to prochloraz. This study contains new data on neopterin and biopterin concentrations in fish plasma and investigates neopterin and biopterin in their non-traditional role as markers of cell mediated immunity of fish associated with pesticide exposure.

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Section: Discussionmentioning

confidence: 88%

Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

et al. 2014

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“…In fish, deltamethrin exposure of Ancistrus multispinis resulted in an increase in NO production by kidney macrophages compared to controls (Pimpao et al, 2008). Hadnagy et al (2003) determined that alterations to the immune system could be detected early (1-3 days) after a professional pest control operation in which a pyrethroidbased insecticide was used. These data provide additional evidence that pyrethroids and pyrethrins have the potential to be immunotoxic to nontarget species.…”

Section: Nonrodent Studiesmentioning

confidence: 99%

“…In Indian major carp (Cirrhinus mrigala) exposed for 45 days to synthetic -permethrin, a reduced response to the bacterial challenge with Aeromonas hydrophila was observed (Nayak et al, 2004). However, 6-12 months later these changes were no longer detectable (Hadnagy et al, 2003). Hadnagy et al (2003) determined that alterations to the immune system could be detected early (1-3 days) after a professional pest control operation in which a pyrethroidbased insecticide was used.…”

Section: Nonrodent Studiesmentioning

confidence: 99%

Immunotoxicity of Pesticides

Brundage

Barnett

2010

Hayes' Handbook of Pesticide Toxicology

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“…Consequently, these chemicals may enter human body in large amounts together with food and water. The latest studies demonstrated that pyrethroids may neg atively affect the immune system [2], cause disorders of the endocrine system [3], and even possess carcino genic effects [4]. Today, a lot of effort is spent on the development of methods to control these compounds in food, soil, and natural water basins.…”

Section: Introductionmentioning

confidence: 99%

Detection of pyrethroids by spectral correlation interferometry

Burenin

Nikitin

Орлов

et al. 2013

Appl Biochem Microbiol

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A label free method based on spectral correlation interferometry has been developed for highly sensitive detection of pyrethroids by competitive immunoassay on the surface of sensor chips made of widely available microscopy glass cover slips. It is shown that the method allows independent optimization of each step of the sensor surface modification. This fact may be used to increase the efficiency of development of protocols for a wide spectrum of immunoassays that employ glass surface as a solid phase. Detection of 3 phenoxybenzoic acid, which is one of the most stable metabolites of a large number of pyrethroids, on the surface of the optimized sensor chips has been demonstrated on the level of 15 pg/ml. That is 50 times better than the sensitivity of the enzyme linked immunosorbent assay (ELISA).

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Pyrethroids used indoors – Immune status of humans exposed to pyrethroids following a pest control operation – a one year follow-up study

Cited by 29 publications

References 20 publications

Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

Immunotoxicity of Pesticides

Detection of pyrethroids by spectral correlation interferometry

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