Pyridine Elaboration Through Organometallic Intermediates: Regiochemical Control and Completeness

Abstract

Pyridines carrying heterosubstituents (such as carboxy, amido, amino, alkoxy or trifluoromethyl groups or solely individual halogen atoms) can be readily and site selectively metalated. Subsequent reaction with a suitable electrophile opens rational access to a wealth of new building blocks for the synthesis of biologically active compounds. This approach relies on organometallic methods, which are both efficacious and extremely flexible as far as the substitution site and the product structure are concerned.

Spectroscopic and Quantum Chemical Studies on the Structure of 3-chloro-2-{(2Z)-2-[1-(4 methoxyphenyl)ethylidene]hydrazinyl}pyridine

“…With that unique dynamic, hydrazones play an important role in studies to develop new drugs [4,5]. Meanwhile, pyridines containing heterosubstitutes are biologically active compounds, and compounds involving the pyridine rings play a similarly significant role in various living systems, including ones involving antibiotics, coenzymes, vitamins and nucleic acids [6]. Beyond that, derivatives of pyridine compounds are used as drugs for brain diseases, anaesthetic agents, agricultural products and pharmaceutical drugs [7].…”

Solubility of some novel cyanopyridine derivatives

“…Pyridine compounds exist in nature in various forms and are integral part of various natural products. 1,2 The pyridine ring plays a key role in catalyzing both biological and chemical reactions. 3 Various substituted pyridines demonstrate a wide range of applications.…”