Pyrido[2,3-d]pyrimidines. IV. Synthetic studies leading to various oxopyrido[2,3-d]pyrimidines

Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety

“…It was found that 7-amino-3-phenyl- [1,2,4]triazolo [4,3-a] pyrimidin-5(1H)-one (5) is an excellent building block for the synthesis of the target objectives.…”

One-Pot Synthesis of Novel Derivatives of Dithioxopyrido[2,3-d:6,5-d’]dipyrimidine-4,6-diones Using Hap-Encapsulated γ-Fe2O3 Supported Sulfonic Acid Nanocatalyst

“…In particular, the synthesis of pyridopyrimidine and their derivatives remains of great interest in organic chemistry, because some of them exhibit significant biological and pharmacological activities, such as antifolate activity [16], antibacterial activity [17], tyrosine kinase activity [18], antimicrobial activity [19], calcium channel antagonists activity [20], anti-inflammatory and analgesic activity [21], antileishmanial activity [22], tuber-culostatic activity [23], anticonvulsants activity [24], diuretic and potassium-sparing activity [25], antiaggressive activity [26], and antitumor activity [27].…”

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

“…These annelated uracils have received considerable attention over the past years due to their wide range of biological activity (Senda et al, 1968;Levitt, 1982;O'Callaghan et al, 1983;Wrigglesworth et al, 1984). Compounds with these ring systems have diverse pharmacological properties such as antiallergic (Kitamura et al, 1984), antihypertensive (Furuya et al, 1994), cardiotonic (Heber et al, 1993), bronchiodilator (Coates, 1990), antitumour activity (Broom et al, 1976). Pyrano [2,3-d] pyrimidine is unsaturated six membered heterocycle which is formed by fusion of pyran and pyrimidine rings together, consisting of one oxygen atom at position number 8 and two nitrogen atoms at position number 1 and 3 respectively.…”