Pyridoxine (Vitamin B6) Toxicity Literature Review

Schneider, Robert A.

doi:10.21236/ad0608841

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Vitamin B6 [also known as Pyridoxal 5-phosphate (PLP)] is an essential cofactor involved in the metabolism of homocysteine and the synthesis of catecholamine and other neurotransmitters [5] . PLP is an important nutrient essential for maintaining normal physiological metabolic activities of the body [6] .…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 as a novel risk biomarker of fractured ankles

Zhang

Wan

et al. 2021

Medicine

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Ankle fractures are the most common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and high risk of fractured ankles. However, the relationship between vitamin B6 and the incidence of fractured ankles in patients with osteoporosis is unclear. A total of 101 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And the vitamin B6, albumin, globulin, and hemoglobin in the blood were tested. Pearson's chi-squared and spearman test were performed to analyze the correlation between fractured ankles and relative parameters. Univariate and multivariate logistic regression, receiver operating characteristic curve analysis, univariate and multivariate Cox proportional hazards regression analysis, and Kaplan–Meier method were also performed. There exist strong relation between the expression level of vitamin B6 and fractured ankle ( P < .001). The expression of vitamin B6 [Odd ratio (OR) = 12.071, 95% confidence interval (CI): 4.69–31.143, P < .001] has a clear correlation with whether the patients have fractured ankles via the univariate logistic regression analysis. In terms of multivariate logistic regression level, vitamin B6 (OR = 15.384, 95% CI:5.195–45.556, P < .001) was significantly associated with fractured ankle. In addition, expression level of vitamin B6 [hazard ratio (HR) = 11.684, 95% CI: 6.419–21.267, P < .001] was significantly associated with Maintenance time from recovery to recurrence (MRTT) of patients with osteoporosis. Enhanced vitamin B6 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of fractured ankles.

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Section: Introductionmentioning

confidence: 99%

Vitamin B6 as a novel risk biomarker of fractured ankles

Zhang

Wan

et al. 2021

Medicine

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“…The health benefits of vitamin A are numerous, but its impact on the cardiovascular system has been a topic of controversy. Some studies have indicated that the consumption of vitamin A does not correlate with the incidence of hypertension [94,95], although research indicates that vitamin A is involved in endothelial function by altering nitric oxide pathways [96]. In addition, vitamin A also acts as an anti-inflammatory agent, and a lack of it can cause or exacerbate inflammation [97].…”

Section: Importance Of Magnesiummentioning

confidence: 99%

How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?

et al. 2023

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide, far ahead of cancer. Epidemiological data emphasize the participation of many risk factors that increase the incidence of CVDs, including genetic factors, age, and sex, but also lifestyle, mainly nutritional irregularities and, connected with them, overweight and obesity, as well as metabolic diseases. Despite the importance of cardiovascular problems in the whole society, the principles of prevention of CVDs are not widely disseminated, especially among the youngest. As a result, nutritional neglect, growing from childhood and adolescence, translates into the occurrence of numerous disease entities, including CVDs, in adult life. This review aimed to draw attention to the role of selected minerals and vitamins in health and the development and progression of CVDs in adults and children. Particular attention was paid to the effects of deficiency and toxicity of the analyzed compounds in the context of the cardiovascular system and to the role of intestinal microorganisms, which by interacting with nutrients, may contribute to the development of cardiovascular disorders. We hope this article will draw the attention of society and the medical community to emphasize promoting healthy eating and proper eating habits in children and adults, translating into increased awareness and a reduced risk of CVD.

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“…While supplementing may prevent micronutrient deficiencies, they tend to provide minerals and vitamins in amounts that exceed the necessary. Recommending the use of multivitamin supplements for women who are pregnant or considering getting pregnant varies from one source to another (Hemminger and Wills, 2020). For instance, the IOM and WHO suggest that multivitamin supplements are best recommended for expecting mothers with poor diets, vegetarians, cigarette smokers, and those who consume alcohol.…”

Section: Use Of Multivitamins In Pregnancymentioning

confidence: 99%

Rational Use of vitamins during pregnancy and The pregnancy multivitamin products’ available in Turkey

Aksoy

Ozturk

2022

Nutr Health

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Background: Despite the imperative role of sufficient vitamin intake during pregnancy, not all women are capable of following a balanced diet during these times. As an attempt to resolve the issue of micronutrient deficiencies, many women resort to the use of multivitamins; ones often made for pregnant women. Aim: The review aims to compare the Daily Recommended Dietary Allowance of each vitamin, micronutrient, and macronutrient with the doses available in a sample of products found in the Turkish markets, whether imported or manufactured in Turkey. Methods: The Daily Recommended Dietary Allowance doses were collected from the CDC, WHO, and IOM databases. The doses present in each product were gathered using the database offered by the Turkish pharmacist association “Tebrp” as well as RxMediaPharma. Elevit® and decavit® were selected as they've been approved by the Turkish Ministry of Health, while the other products were randomly chosen using a computer program. Results: Several formulations available in Turkey display higher or lower daily contents of vitamins and minerals than is normally ideal for pregnant women as specified by the Recommended Dietary Allowance (RDA). Formulations that exceed the recommended RDA while remaining underneath the tolerable Upper Intake Level (UL) range for specific vitamins includes Pregnacare®, Decavit®, and Elevit®. Conclusion: All of these variances in multivitamin content must be considered by physicians and clinical pharmacists when selecting the appropriate multivitamin for pregnant women, taking into account all of the hazards and benefits that vitamin supplements may bring to fetus health and development.

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Pyridoxine (Vitamin B6) Toxicity Literature Review

Cited by 4 publications

References 4 publications

Vitamin B6 as a novel risk biomarker of fractured ankles

Vitamin B6 as a novel risk biomarker of fractured ankles

How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?

Rational Use of vitamins during pregnancy and The pregnancy multivitamin products’ available in Turkey

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