Pyrimidinethione as a building block in heterocyclic synthesis: synthesis of pyrano[2,3-d]pyrimidine, chromeno[2,3-d]pyrimidine, pyrido[3′,2′:5,6]pyrano[2,3-b]pyridine, and pyrimido[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives

Abstract

New heterocyclic compounds with expected biological activity have been prepared by reactions of 6-phenyl-2-thioxo-2,3-dihydropyrimidine-4(5

Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

“…Abdel-Reheim et al 138 have reported the synthesis of dihydropyrimidinone 67 from the reaction of thiourea with ethyl benzoyl acetate and applied this compound in the multi-step synthesis of bicyclic pyranopyrimidines by reactions with arylidenes, or by the multicomponent reaction with formaldehyde, and malononitrile. Also, the reactivity of pyranopyrimidine 69b towards diverse reagents e.g.…”

Triethylammonium Hydrogen Sulfate [Et3NH][HSO4]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine and Pyrazolo[3,4-b]pyridine Hybrids

“…Carbon–heteroatom and carbon–carbon bond-forming reactions lie at the heart of organic synthesis. Multicomponent reactions (MCRs) have been recognized as valuable tools in modern organic synthesis for the drug discovery process and the total synthesis of natural products. − MCRs can provide access to a library of complex structures in a straightforward manner, and diversity can be achieved for building up compound libraries by simply varying each component. , Over the past four decades, there has been a huge development in three- and four-component reactions, and great endeavor continues to be made to expand new MCRs. − …”