Pyrolysis of Other Nitrogen-Containing Compounds

Moldoveanu, Serban C.

doi:10.1016/b978-0-444-64000-0.00009-3

Cited by 6 publications

(5 citation statements)

References 108 publications

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“…Many studies have proved by theoretical calculations and experiments that during the decomposition process, MNB first underwent the isomerization of the nitro group to form nitrosobenzene as the intermediate products. , However, the intermediate nitrosobenzene was not detected for both MNB and the MNB/sodium phenolate mixture in Figure a. The reason for this phenomenon was that the formed intermediate nitrosobenzene rapidly converted to the aniline.…”

Section: Resultsmentioning

confidence: 99%

Thermal Behavior and Decomposition Pathway for Nitrophenols and Sodium Nitrophenolates

Weng

Feng

et al. 2023

Org. Process Res. Dev.

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Nitrophenols and corresponding sodium nitrophenolates are the main side products in the production of mononitrobenzene (MNB). These side products are hazardous due to their thermal instability nature. In this article, the thermal decomposition behaviors of nitrophenols and sodium nitrophenolates were first characterized by differential scanning calorimeter and accelerating rate calorimetry techniques. Then, the influence of phenol and sodium phenolate on the thermal decomposition of MNB was studied to clarify the effect of phenolic hydroxyl groups on the thermal stability of nitrophenols. It was found that compared to nitrophenols, the exothermic peaks of sodium nitrophenolates were more intense and presented strongly autocatalytic features. Sodium phenolate could significantly decrease the decomposition temperature of MNB. Aniline was detected as the unique product in the decomposition processes of pure MNB and MNB/sodium phenolate mixtures, and the nitrosobenzene was verified as the intermediate product. It was experimentally proven that sodium phenolate could catalyze the decomposition of nitrosobenzene (the decomposition intermediate of MNB). The violent decomposition of sodium nitrophenols was caused by the intermolecular catalysis effect of phenoxy groups.

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Section: Resultsmentioning

confidence: 99%

Thermal Behavior and Decomposition Pathway for Nitrophenols and Sodium Nitrophenolates

Weng

Feng

et al. 2023

Org. Process Res. Dev.

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“…Hydrazones represent an established structural class as they provide a varied array of structurally distinct ligands that are versatile and capable of mimicking biological systems. [4] This class has gained prominence due to its optical, [5][6][7][8][9] photoluminescent, [10,11] thermal [12,13] and several biological properties. [14][15][16][17][18][19][20][21][22][23][24] The presence of imine linkage in these frameworks causes a variety of racemization responses in the biological system.…”

Section: Introductionmentioning

confidence: 99%

Exploration of structural, electrostatic and photophysical behaviour of novel Ni(II), Cu(II) and Zn(II) complexes and their utility as potent antimicrobial agents

Bala

Singh

Kataria

et al. 2022

Applied Organom Chemis

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In the present manuscript, a series of Ni(II), Cu(II) and Zn(II) based metal complexes were synthesized, and their molecular geometry was established using single‐crystal X‐ray diffraction studies. The surface characteristic along with the presence of various intermolecular interactions was quantified using crystal explorer. The atom‐based contribution of various molecular interactions in the overall interactions was evaluated by the decomposition of Hirshfeld surfaces into a 2D fingerprint region. DFT‐based global reactivity descriptors were calculated to gain an idea about the chemical reactivity and stability. A reduction in the energy gap on complexation along with a red shift in the absorption spectra confirms the formation of metal complexes. The presence of a small energy gap in case of Cu(II) complex reflects the presence of an efficient electronic charge transfer mechanism in this case. The photophysical properties of L2 and its metal complexes were also evaluated in different solvents. A maximum stoke shift of 6234.51 cm−1 was exhibited by M2D when its spectra were recorded in MeOH. The bio‐efficacy of L2 and its metal complexes (M2A, M2C and M2D) were evaluated using in vitro anti‐microbial assays. Maximum inhibition of both bacterial and fungal growth was exhibited by M2A with an MIC value of 32 μg mL−1 against B. cereus, X. campestris, and C. albicans. The fluorescence‐based approach was used to conduct BSA binding studies with all three metal complexes. The presence of a positive entropy change (S) value implies that protein‐ligand binding is entropy‐driven by hydrophobic interactions. Finally, in silico molecular docking and dynamics investigations were carried out to explore the most probable mode of C. albicans inhibition.

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“…Hydrazone ligation has been widely applied to bioconjugation due to its orthogonality, and both hydrazine and carbonyl groups are naturally present in small molecules . The hydrazone bond is small, consisting only of three atoms (CN-NH), thus creating a minimal disturbance of the native biomolecule . In the study, the first peptide fragment 1–38 Hi1a was synthesized with a C-terminal hydrazide, and the second fragment ( 39–75 [F39S]Hi1a) was assembled with Ser replacing the N-terminal Phe39 to enable conversion to a bialdehyde before ligation (Figure S3C).…”

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confidence: 99%

“…14 The hydrazone bond is small, consisting only of three atoms (C�N-NH), thus creating a minimal disturbance of the native biomolecule. 15 In the study, the first peptide fragment 1−38 Hi1a was synthesized with a C-terminal hydrazide, and the second fragment ( 39−75 [F39S]Hi1a) was assembled with Ser replacing the N-terminal Phe39 to enable conversion to a bialdehyde before ligation (Figure S3C). Following synthesis via Fmoc-SPPS and oxidative folding of each of the peptide fragments as described above (5 mg of each oxidized fragment from 75 mg of precursors, yield 6%) (Table S1, Figure S3A,B), the two fragments were ligated in sodium acetate buffer at pH 4.3 to form folded full-length Hi1a with a hydrazone bond in the linker (Figure 1D) after 30 min (1.3 mg, 47% conversion yield) (Figure 2B, Figure S4, Figure S7).…”

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confidence: 99%

Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a

et al. 2023

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Hi1a is a naturally occurring bivalent spider-venom peptide that is being investigated as a promising molecule for limiting ischemic damage in strokes, myocardial infarction, and organ transplantation. However, the challenges associated with the synthesis and production of the peptide in large quantities have slowed the progress in this area; hence, access to synthetic Hi1a is an essential milestone for the development of Hi1a as a pharmacological tool and potential therapeutic.

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Pyrolysis of Other Nitrogen-Containing Compounds

Cited by 6 publications

References 108 publications

Thermal Behavior and Decomposition Pathway for Nitrophenols and Sodium Nitrophenolates

Thermal Behavior and Decomposition Pathway for Nitrophenols and Sodium Nitrophenolates

Exploration of structural, electrostatic and photophysical behaviour of novel Ni(II), Cu(II) and Zn(II) complexes and their utility as potent antimicrobial agents

Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a

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